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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (05) : 454 -459. doi: 10.3877/cma.j.issn.2095-3224.2026.05.010

综述

加压腹腔气溶胶化疗联合治疗策略在结直肠癌腹膜转移中的研究进展
齐劲杨1, 牛河源1, 李晓萍1, 范星灿1, 刘子俊1, 刘刚1,2,†()   
  1. 1 300052 天津医科大学总医院普通外科
    2 300052 天津医科大学外科日间诊疗中心
  • 收稿日期:2026-04-08 出版日期:2026-10-25
  • 通信作者: 刘刚

Pressurized intraperitoneal aerosol chemotherapy combined treatment strategies for peritoneal metastases from colorectal cancer

Jinyang Qi1, Heyuan Niu1, Xiaoping Li1, Xingcan Fan1, Zijun Liu1, Gang Liu1,2,†()   

  1. 1 Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    2 Ambulatory Surgery Center, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2026-04-08 Published:2026-10-25
  • Corresponding author: Gang Liu
引用本文:

齐劲杨, 牛河源, 李晓萍, 范星灿, 刘子俊, 刘刚. 加压腹腔气溶胶化疗联合治疗策略在结直肠癌腹膜转移中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(05): 454-459.

Jinyang Qi, Heyuan Niu, Xiaoping Li, Xingcan Fan, Zijun Liu, Gang Liu. Pressurized intraperitoneal aerosol chemotherapy combined treatment strategies for peritoneal metastases from colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(05): 454-459.

结直肠癌腹膜转移(CRCPM)常伴腹腔积液、腹痛和营养风险,影像学上的可测病灶发展程度与患者症状之间并不总是对应,治疗时既要顾及全身病灶,也要处理腹腔局部问题。加压腹腔气溶胶化疗(PIPAC)是在气腹条件下将化疗药物气溶胶化后送入腹腔,使药物沉积于腹膜表面并作用于浅层病灶。近年研究显示,PIPAC可用于症状控制、腹膜病灶重复活检评价以及部分患者的转化治疗;但现有资料多来自早期试验、单臂队列和回顾性研究,患者选择及联合方案差异较大。本文结合全身化疗、靶向治疗及CRS+HIPEC转化治疗相关研究,讨论PIPAC在CRCPM综合治疗中的可能位置。

Colorectal cancer peritoneal metastasis (CRCPM) is often accompanied by ascites, abdominal pain and nutritional decline. Measurable lesions on imaging do not always correspond to the patient’s symptoms; therefore, treatment needs to consider both systemic disease and local intraperitoneal problems. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) delivers aerosolized chemotherapeutic agents into the abdominal cavity under pneumoperitoneum, allowing drug deposition on the peritoneal surface and exposure of superficial lesions. Recent studies suggest that PIPAC may be used for symptom control, repeated biopsy-based assessment of peritoneal disease and conversion treatment in selected patients. However, current evidence mainly comes from early-phase trials, single-arm cohorts and retrospective studies, with considerable heterogeneity in patient selection and combined regimens. This review summarizes studies of PIPAC combined with systemic chemotherapy, targeted therapy and CRS+HIPEC, and discusses the potential role of PIPAC in the multidisciplinary treatment of CRCPM.

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