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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (04) : 307 -314. doi: 10.3877/cma.j.issn.2095-3224.2026.04.003

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盆腔脏器联合切除术中的ERAS与PROMs:从医生视角到患者视角的转变
张若昕, 陆瑶, 刘益磊, 陈国良, 张剑()   
  1. 200003 上海,海军军医大学第二附属医院(上海长征医院)肛肠外科
  • 收稿日期:2026-03-18 出版日期:2026-08-25
  • 通信作者: 张剑
  • 基金资助:
    国防科技卓越青年科学基金项目(2019-JCJQZQ-002); 军队高层次科技创新人才工程学科拔尖人才计划(第(2020)BJ06038)

ERAS and PROMs in pelvic exenteration: from physician to patient perspective

Ruoxin Zhang, Yao Lu, Yilei Liu, Guoliang Chen, Jian Zhang()   

  1. Department of Colorectal Surgery, Shanghai Changzheng Hospital, the Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
  • Received:2026-03-18 Published:2026-08-25
  • Corresponding author: Jian Zhang
引用本文:

张若昕, 陆瑶, 刘益磊, 陈国良, 张剑. 盆腔脏器联合切除术中的ERAS与PROMs:从医生视角到患者视角的转变[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(04): 307-314.

Ruoxin Zhang, Yao Lu, Yilei Liu, Guoliang Chen, Jian Zhang. ERAS and PROMs in pelvic exenteration: from physician to patient perspective[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(04): 307-314.

盆腔脏器联合切除术(PE)是治疗局部晚期或复发性盆腔恶性肿瘤的根治性选择之一,但其创伤大、并发症率高、围手术期死亡风险显著,使临床决策和患者选择极具挑战性。传统研究多聚焦于R0切除率、生存率等“医生视角”的结局,而相对忽视患者长期生活质量和决策体验。近年来,加速康复外科(ERAS)理念被逐步引入PE,但现有证据提示:一方面,在PE中应用ERAS与住院时间缩短和重度并发症降低相关;另一方面,简单照搬常规结直肠或妇科ERAS路径,在PE人群中可能导致肠麻痹、尿漏和盆腔脓肿等并发症发生率增加。患者报告结局(PROMs)及生活质量标准(QoL)等指标显示,部分患者即使获得R0切除和长期生存,仍对接受PE的决定持矛盾心理,甚至存在决策后悔。本文在梳理PE解剖和人群特征、围手术期挑战的基础上,系统总结ERAS在PE中的应用现状与主要研究结果,综述PE后长期生存和生活质量的证据,重点讨论医生视角与患者视角在结局评价上的差异,并提出以风险分层和PROMs为基础的PE专属ERAS路径及多学科、以患者为中心的管理建议,以期为临床实践和未来研究提供参考框架。

Pelvic exenteration (PE) is one of the radical surgical options for treating locally advanced or recurrent pelvic malignancies. However, due to its high degree of invasiveness, elevated complication rates, and significant perioperative mortality, clinical decision-making and patient selection present substantial challenges. Traditional studies have primarily focused on outcomes from the physician’s perspective, such as R0 resection rates and survival, while often overlooking patients’ long-term quality of life and decision-making experiences. In recent years, the concept of enhanced recovery after surgery (ERAS) has been gradually introduced into PE. Current evidence suggests that while the application of ERAS in PE is associated with reduced hospital stays and a lower incidence of severe complications, the simple adoption of standard colorectal or gynecological ERAS protocols in the PE population may lead to increased complications such as intestinal paralysis, urinary leakage, and pelvic abscesses. Metrics including patient-reported outcomes (PROMs) and quality of life (QoL), indicate that some patients, even after achieving R0 resection and long-term survival, still express hesitation or regret regarding their decision to undergo PE. This review, based on an analysis of the anatomical and demographic characteristics of PE as well as perioperative challenges, systematically summarizes the current status and main findings of ERAS application in PE, synthesizes evidence on long-term survival and quality of life following PE, highlights the discrepancies in outcome evaluation between physician-centered and patient-centered perspectives, and proposes a risk-stratified, PROMs-based PE-specific ERAS pathway alongside multidisciplinary, patient-centered management recommendations. The aim is to provide a reference framework for clinical practice and future research.

图1 PE手术的膜解剖示意图(笔者团队绘制)
表1 ERAS推荐意见
阶段 推荐意见 指南 已发表文献
TME[25] 妇科肿瘤[27] 泌尿外科[31] PelvEx合作组[29] Harji[30] Wan[32] Huepenbecker[11] Nordkamp[33]
入院前 麻醉咨询
心肺功能测定
实验室检查
康复评估
营养评估
个人信息咨询
戒烟限酒
血糖控制
术前 备血 √,2 U悬浮红细胞
口服碳水化合物
肠道准备 避免 避免
禁食禁水
预防性使用抗生素
预防深静脉血栓
预防术后呕吐
术前镇痛
术中 血管通路 √,动脉导管 √动脉导管,静脉留置针
温度管理 √,通风供暖 √,通风供暖
实验室监测 √,血糖 √,血气分析、血蛋白、乳酸
小腿袜压迫
体位管理 √,每2~4小时活动下肢
出血管理 √,氨甲环酸
升压药 √,去甲肾上腺素 √,去甲肾上腺素
疼痛管理/麻醉
鼻胃管 避免 避免 避免
腹部引流管 避免,除非尿路切除 避免 避免 避免
术后 疼痛管理
术后转入ICU √,POD2 √,POD2
饮食 √,每日渐进 √,早期 √,早期 √,POD3 √,POD3 √,POD0 √,每日渐进
补液 √,40 mL/h
腹部引流管拔出 √,引流<200可POD2 √,POD8 √,POD8
预防深静脉血栓
下床活动 √,每日渐进 √,早期 √,每日渐进 √,POD1辅助行走 √,POD1辅助行走 √,POD1 √,POD0 √,每日渐进
预防术后呕吐
预防肠梗阻
每日称重
输血
心理辅导 √,POD30 √,POD7 √,POD30
表2 PROMs工具
评估维度 推荐工具 英文全称 中文全称 评估时点 参考值类型 参考值/阈值
总体生活质量 EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 欧洲癌症研究与治疗组织生活质量核心量表(30条目) 术前基线、术后3/6/12个月、此后每年 MCID(双向) 功能维度5~10分;症状维度5~10分
结直肠功能 LARS Score Low Anterior Resection Syndrome Score 低位前切除综合征评分 术后6个月起(肠道功能稳定后) 分类阈值(非MCID) 无LARS 0~20分;轻度21~29分;重度30~42分
性功能(女性) FSFI Female Sexual Function Index 女性性功能指数 术后6/12个月 诊断截断值(非MCID) 总分≤26.55分提示性功能障碍
性功能(男性) IIEF-15 International Index of Erectile Function 国际勃起功能指数(15条目版) 术后6/12个月 诊断截断值(非MCID) 勃起功能维度(EF,6条目)≤25分提示勃起功能障碍
排尿功能 ICIQ-SF International Consultation on Incontinence Questionnaire-Short Form 国际尿失禁咨询委员会尿失禁问卷简表 术后3/6/12个月 诊断截断值(非MCID) 总分≥1分提示尿失禁存在
造口相关生活质量 Stoma-QoL Stoma Quality of Life Questionnaire 造口生活质量量表 术后1/3/6/12个月 尚无公认MCID 部分研究以0.5 SD估算研究特异性MCID
盆腔症状负担 EORTC QLQ-CR29 EORTC Quality of Life Questionnaire-Colorectal Cancer 29 欧洲癌症研究与治疗组织生活质量量表-结直肠癌模块(29条目) 术前基线、术后3/6/12个月 尚无公认MCID 需与QLQ-C30联合使用
结直肠癌特异生活质量 FACT-C Functional Assessment of Cancer Therapy-Colorectal 癌症治疗功能评估系统-结直肠癌量表 术前基线、术后1/3/6/12个月 MCID CCS 2~3分;TOI-C 4~6分;总分5~8分
心理适应/决策后悔 DRS Decision Regret Scale 决策后悔量表 术后6/12个月 经验性阈值(非正式MCID) 总分>25分提示显著决策后悔
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