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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (03) : 269 -273. doi: 10.3877/cma.j.issn.2095-3224.2026.03.010

综述

肠道微生物组在结直肠癌化疗中的双向调控作用
张瑞豪, 李文星()   
  1. 030001 太原,山西医科大学第二医院普通外科
  • 收稿日期:2025-12-03 出版日期:2026-06-25
  • 通信作者: 李文星
  • 基金资助:
    山西省基础研究计划项目(202503021211284)

The bidirectional regulatory role of the gut microbiome in colorectal cancer chemotherapy

Ruihao Zhang, Wenxing Li()   

  1. Department of General Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2025-12-03 Published:2026-06-25
  • Corresponding author: Wenxing Li
引用本文:

张瑞豪, 李文星. 肠道微生物组在结直肠癌化疗中的双向调控作用[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(03): 269-273.

Ruihao Zhang, Wenxing Li. The bidirectional regulatory role of the gut microbiome in colorectal cancer chemotherapy[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(03): 269-273.

结直肠癌是全球范围内高发病率和死亡率的恶性肿瘤。对于术后辅助治疗及晚期患者,化疗是核心治疗手段,但其应用常受限于耐药性与剂量限制性毒性(如腹泻、神经毒性、黏膜炎等)。近年来,肠道微生物组作为人体的“第二基因组”,被证实与化疗药物存在密切的双向调控作用:一方面,化疗药物会重塑肠道菌群结构;另一方面,菌群及其代谢产物又能显著影响化疗药物的疗效与毒性。本综述旨在系统解析“化疗-菌群”双向互作的核心机制,并重点探讨以菌群为靶点逆转耐药性、减轻毒副作用的精准干预策略,对实现其临床转化、制订个性化方案具有重要意义。

Colorectal cancer is a malignant tumor with high incidence and mortality worldwide. Chemotherapy serves as the core treatment for adjuvant therapy after surgery and advanced-stage patients; however, its application is often limited by drug resistance and dose-limiting toxicities (such as diarrhea, neurotoxicity, mucositis, etc.). In recent years, the gut microbiota, recognized as the “second genome” of the human body, has been confirmed to have a close bidirectional interaction with chemotherapeutic drugs: on the one hand, chemotherapeutic drugs can reshape the structure of the gut microbiota; on the other hand, the microbiota and their metabolites can significantly affect the efficacy and toxicity of chemotherapeutic drugs. This review aims to systematically elaborate on the core mechanisms underlying the bidirectional interaction between chemotherapy and gut microbiota, and focuses on exploring precise intervention strategies targeting the microbiota to reverse drug resistance and alleviate adverse effects. It holds great significance for achieving clinical translation and formulating personalized treatment plans.

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