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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (04) : 299 -306. doi: 10.3877/cma.j.issn.2095-3224.2026.04.002

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大肠黏液腺癌的研究进展
金磊, 印小毛, 李新星, 胡志前()   
  1. 200065 上海,同济大学附属同济医院普外科
  • 收稿日期:2025-09-30 出版日期:2026-08-25
  • 通信作者: 胡志前
  • 基金资助:
    上海市卫生健康委员会面上项目(202340231); 沪滇科技协调创新项目(26HD0700100); 上海市科学技术委员会国际合作项目(25HB2716600); “医学+X”交叉研究项目(2026-0313-YB-09); 高校自主原创基础研究项目(20230106); 上海市科委医学创新研究专项青年项目(23Y11902400); 上海市同济医院临床研究项目(ITJ(ZD)2308)

Progress in the mucinous colorectal adenocarcinoma

Lei Jin, Xiaomao Yin, Xinxing Li, Zhiqian Hu()   

  1. Department of General Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China
  • Received:2025-09-30 Published:2026-08-25
  • Corresponding author: Zhiqian Hu
引用本文:

金磊, 印小毛, 李新星, 胡志前. 大肠黏液腺癌的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(04): 299-306.

Lei Jin, Xiaomao Yin, Xinxing Li, Zhiqian Hu. Progress in the mucinous colorectal adenocarcinoma[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(04): 299-306.

结直肠癌为全球常见恶性肿瘤之一,大肠黏液腺癌作为其独特的病理亚型,占结直肠癌的10%~20%,以肿瘤组织中细胞外黏蛋白成分占比≥50%为核心病理特征。该疾病好发于女性和年轻患者,病变多累及右半结肠,确诊时分期较晚,且易合并腹膜转移与淋巴结浸润,整体预后较差。与普通腺癌相比,黏液腺癌具有显著独特的分子特征,这可能与其对辅助治疗耐受性及预后不良相关,但发病机制尚未明确。组织活检是诊断黏液腺癌的金标准,CT、MRI等影像学检查在其诊断方面亦具优势。目前缺乏针对黏液腺癌的权威临床指南,治疗策略多参考腺癌方案,其疗效和预后存在争议。本文系统阐述了黏液腺癌在流行病学、分子背景、诊断、治疗、预后及最新研究方向等方面的研究进展,以期为后续基础与临床研究提供参考。

Colorectal cancer is one of the common malignant tumors in the world, among which mucinous adenocarcinoma of the large intestine is a unique pathological subtype, accounting for 10%~20% of all colorectal cancer cases. It is characterized by extracellular mucin components accounting for no less than 50% of the tumor volume. This disease has a higher incidence in women and young people, and is often diagnosed at an advanced stage with a high rate of peritoneal metastasis and lymph node infiltration, leading to a poor overall prognosis. Compared with adenocarcinoma, mucinous adenocarcinoma has significant differences in molecular characteristics, which may be related to resistance to adjuvant therapy and poor prognosis, but the pathogenesis has not been clear. Tissue biopsy is the gold standard for diagnosis, while CT, MRI and other imaging modalities also have diagnostic advantages. At present, there is a lack of special clinical guidelines for mucinous adenocarcinoma, and the treatment strategy mostly refers to the scheme of adenocarcinoma, and its efficacy and prognosis are controversial. This article reviews the research progress of mucinous adenocarcinoma in epidemiology, molecular background, diagnosis, treatment, prognosis and the latest research directions, in order to provide references for subsequent basic and clinical research.

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你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?