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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (04) : 356 -360. doi: 10.3877/cma.j.issn.2095-3224.2026.04.009

综述

Treg细胞在结直肠癌中的作用机制及靶向治疗研究进展
林佳仪, 黄颖()   
  1. 350004 福建医科大学协和临床医学院
  • 收稿日期:2026-02-26 出版日期:2026-08-25
  • 通信作者: 黄颖

Research progress on the mechanism and targeted therapy of Treg cells in colorectal cancer

Jiayi Lin, Ying Huang()   

  1. Union Clinical Medical College, Fujian Medical University, Fuzhou 350004, China
  • Received:2026-02-26 Published:2026-08-25
  • Corresponding author: Ying Huang
引用本文:

林佳仪, 黄颖. Treg细胞在结直肠癌中的作用机制及靶向治疗研究进展[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(04): 356-360.

Jiayi Lin, Ying Huang. Research progress on the mechanism and targeted therapy of Treg cells in colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(04): 356-360.

调节性T细胞(Treg)是结直肠癌肿瘤微环境(TME)中介导免疫抑制的重要免疫成分,其通过多种机制实现肿瘤免疫逃逸,促进肿瘤进展。本文综述了Treg细胞的生物学特性、内在异质性,及介导免疫抑制的相关机制,包括分泌抑制性细胞因子、营养竞争、代谢干扰和形成特定空间生态位等,并总结靶向Treg细胞的治疗策略从单纯耗竭向精准调控的发展和转变,为结直肠癌的免疫治疗提供新的方向。

Regulatory T cells (Tregs) are key immune components that mediate immunosuppression in the colorectal cancer tumor microenvironment (TME), facilitating tumor immune evasion and promoting tumor progression through various mechanisms. This article reviews the biological characteristics and intrinsic heterogeneity of Treg cells, as well as the mechanisms by which they mediate immunosuppression, including the secretion of inhibitory cytokines, nutrient competition, metabolic interference, and the formation of specific spatial niches. Furthermore, it summarizes the evolution and shift of Treg-targeted therapeutic strategies from simple depletion toward precise regulation, offering new directions for immunotherapy in colorectal cancer.

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