结直肠癌侵袭转移是导致患者预后不良、术后复发及死亡的首要原因，现有化疗等干预手段因毒副作用显著难以满足临床需求。中医药基于整体观念与辨证论治，遵循扶正祛邪、清热解毒、健脾补肾、活血化瘀等治则，在遏制结直肠癌侵袭转移方面凸显独特价值。Wnt/β-catenin、磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）、Janus激酶2/信号转导和转录激活因子3（JAK2/STAT3）、核转录因子-κB（NF-κB）及血管内皮生长因子（VEGF）通路是调控结直肠癌侵袭转移的核心信号网络。本文将系统梳理近年来中药复方及单体通过调控上述相关信号通路抑制结直肠癌侵袭转移的研究进展，凸显中医药整体作用机制正从传统单一通路调控模式向多通路网络整合，为结直肠癌的中医药防治提供依据。

Invasion and metastasis of colorectal cancer are the primary causes of poor prognosis, postoperative recurrence and death in patients. The current intervention methods (such as chemotherapy) are difficult to meet clinical demand due to significant toxic and side effects. Based on holistic concept and differential treatment, traditional Chinese medicine follows different therapeutic principles, including strengthening body resistance and eliminating evil, clearing heat and removing toxicity, invigorating spleen and kidney, activating blood and dissolving stasis, and it demonstrates unique value in inhibiting the invasion and metastasis of colorectal cancer. The pathways of Wnt/β-catenin, phosphatidylinositol-3 kinase/protein kinase B (PI3K/Akt), Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3), nuclear factor-κB (NF-κB) and vascular endothelial growth factor (VEGF) are core signal networks to regulate invasion and metastasis of colorectal cancer. This article will systematically review the research progress on Chinese medicine compounds and monomer inhibiting colorectal cancer invasion and metastasis by regulating the above-mentioned signaling pathways in recent years, and highlight the integration that overall action mechanism of traditional Chinese medicine is shifting from the traditional single-pathway regulation model to a multi-pathway network so as to provide the basis for TCM prevention and treatment of colorectal cancer.