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中华结直肠疾病电子杂志 ›› 2023, Vol. 12 ›› Issue (04) : 331 -336. doi: 10.3877/cma.j.issn.2095-3224.2023.04.010

综述

结直肠癌粪便筛查的现状与展望
鄂一民, 孙司正, 范小彧, 喻春钊()   
  1. 210011 南京医科大学第二附属医院普外科
    210011 南京医科大学第二附属医院普外科;211112 南京医科大学附属逸夫医院普外科
  • 收稿日期:2022-11-25 出版日期:2023-08-25
  • 通信作者: 喻春钊
  • 基金资助:
    国家重点研发计划(2018YFE0127300); 江苏省“333工程”培养资金(BRA2020091); 江苏省科技计划重点项目(BE2019759)

Present status and prospect of fecal screening for colorectal cancer

Yimin E, Sizheng Sun, Xiaoyu Fan, Chunzhao Yu()   

  1. Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
    Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China; Department of General Surgery, Sir Run Run Hospital Nanjing Medical University, Nanjing 211112, China
  • Received:2022-11-25 Published:2023-08-25
  • Corresponding author: Chunzhao Yu
引用本文:

鄂一民, 孙司正, 范小彧, 喻春钊. 结直肠癌粪便筛查的现状与展望[J/OL]. 中华结直肠疾病电子杂志, 2023, 12(04): 331-336.

Yimin E, Sizheng Sun, Xiaoyu Fan, Chunzhao Yu. Present status and prospect of fecal screening for colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(04): 331-336.

结直肠癌是世界范围内常见的消化系统恶性肿瘤之一,常因早期症状不易察觉或不典型而被忽视或延误诊治。近年来,以粪便为标本的非侵入性结直肠癌筛查方法因其简便、无创、经济等因素在基层及临床广泛开展。粪便隐血试验是目前结直肠癌非侵入性筛查中最重要的手段之一,其他粪便筛查方法仍待进一步研究和验证。多种方式的粪便筛查联合检测较单一方法表现出了更好的灵敏度,这提示可以联合多种非侵入性筛查方法构建结直肠癌筛查模型,以精确更适合行结肠镜检查的目标人群。本文就结直肠癌粪便筛查方法的现状及未来进行综述。

Colorectal cancer is one of the most common malignant tumors of the digestive system in the world. Due to the unnoticeable or atypical early symptoms, colorectal cancer is often ignored or delayed in diagnosis and treatment. In recent years, non-invasive colorectal cancer screening methods based on stool specimens have been widely used at the grassroots and clinical level due to their simplicity, non-invasiveness and economic factors. Fecal occult blood test is the most important method for non-invasive screening of colorectal cancer. Other fecal screening methods still need to be further studied and validated. The combination of multiple methods of fecal screening showed better sensitivity than single methods, suggesting that multiple non-invasive screening methods can be combined to construct colorectal cancer screening models that are more accurately suited to the target population undergoing colonoscopy. This article reviews the current status and future of fecal screening methods for colorectal cancer.

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