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中华结直肠疾病电子杂志 ›› 2023, Vol. 12 ›› Issue (04) : 337 -341. doi: 10.3877/cma.j.issn.2095-3224.2023.04.011

综述

初始不可切除的结直肠癌肝转移转化治疗的研究进展
刘玉星, 刘晨鸣, 杜金林()   
  1. 310030 杭州,浙江大学医学院;321000 浙江大学医学院附属金华医院结直肠肛门外科
    310030 杭州,浙江大学医学院;312000 浙江大学绍兴医院肝胆胰外科
    321000 浙江大学医学院附属金华医院结直肠肛门外科
  • 收稿日期:2023-03-20 出版日期:2023-08-25
  • 通信作者: 杜金林
  • 基金资助:
    金华市科技计划项目(2019-3-004)

Progress in conversion therapy of liver metastasis in initially unresectable colorectal cancer

Yuxing Liu, Chenming Liu, Jinlin Du()   

  1. Medical College of Zhejiang University, Hangzhou 310030, China; Department of Colorectal and Anal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China
    Medical College of Zhejiang University, Hangzhou 310030, China; Department of Hepatobiliary and Pancreatic Surgery, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, China
    Department of Colorectal and Anal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China
  • Received:2023-03-20 Published:2023-08-25
  • Corresponding author: Jinlin Du
引用本文:

刘玉星, 刘晨鸣, 杜金林. 初始不可切除的结直肠癌肝转移转化治疗的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(04): 337-341.

Yuxing Liu, Chenming Liu, Jinlin Du. Progress in conversion therapy of liver metastasis in initially unresectable colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(04): 337-341.

结直肠癌是全球癌症相关死亡的第二大原因,已经成为发病率居全球第三位的恶性肿瘤。大约25%的患者在首次诊断时表现为结直肠癌肝转移(CRLM),手术治疗通常被认为是CRLM患者潜在长期生存的必要条件。CRLM初始可切除患者的中位总生存期(OS)为42个月,5年生存率为35%~40%,而初始可切除率不足20%。因此,通过转化治疗后,对初始不可切除的CRLM进行手术切除,将显著改善CRLM患者的预后。在这篇综述中,我们介绍了关于初始不可切除CRLM转化治疗的最新文献,并讨论了其诊断,治疗方法及疗效等研究进展,以期指导临床实践。

Colorectal cancer is the second largest cause of cancer-related death in the world, and ranks as the third most common malignant tumor in the world. Approximately 25% of patients present with colorectal liver metastases(CRLM) at first diagnosis, and surgical treatment is often considered necessary for the potential long-term survival of patients with CRLM. The median overall survival (OS) of patients who achieved R0 resection in CRLM was 42 months, and the 5-year survival rate was 35%~40%. The initial resectable rate is less than 20%. Therefore, surgical resection of initial unresectable CRLM after conversion therapy will significantly improve the prognosis of patients with CRLM. In this review, we introduce the latest literature on initial unresectable CRLM conversion therapy,and discuss the advances in diagnosis, treatment methods and therapeutic effects, so as to guide clinical practice.

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