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中华结直肠疾病电子杂志 ›› 2015, Vol. 04 ›› Issue (01) : 54 -57. doi: 10.3877/cma.j.issn.2095-3224.2015.01.12

所属专题: 文献

论著

结直肠癌中SCC-S2的表达及意义
赵婷婷1, 刑鹏1, 李继光1,()   
  1. 1. 110000 沈阳,中国医科大学肿瘤研究所
  • 收稿日期:2015-01-15 出版日期:2015-02-25
  • 通信作者: 李继光
  • 基金资助:
    国家自然科学基金(81272718)

Expression and the significance of SCC-S2 in colorectal cancer

Ting-ting ZHAO1, Peng XING1, Ji-guang LI1,()   

  1. 1. Tumor Research Institute of China Medical University, Shenyang 110013, China
  • Received:2015-01-15 Published:2015-02-25
  • Corresponding author: Ji-guang LI
  • About author:
    Corresponding author: LI Ji-guang, Email: .
引用本文:

赵婷婷, 刑鹏, 李继光. 结直肠癌中SCC-S2的表达及意义[J/OL]. 中华结直肠疾病电子杂志, 2015, 04(01): 54-57.

Ting-ting ZHAO, Peng XING, Ji-guang LI. Expression and the significance of SCC-S2 in colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(01): 54-57.

目的

SCC-S2是近期发现的一种在多种癌症中过表达,并且与癌细胞的恶性生物学行为关系密切的物质。但是在结直肠癌中,SCC-S2的表达和生物学作用未见报道。本研究目的是探索SCC-S2在结直肠癌及其癌旁正常组织中的表达水平,探讨SCC-S2与结直肠癌患者临床病理特征的关系。

方法

本研究应用免疫组化分析了SCC-S2在136例结直肠癌组织中的表达情况,使用SPSS 18.0软件进行统计分析。

结果

67例(49.26%)结直肠癌标本SCC-S2过表达。SCC-S2的过表达与结直肠癌的TNM分期显著相关(P<0.01);与淋巴结转移显著相关(P<0.05);与细胞增殖指数显著相关(P>0.01)。

结论

SCC-S2在结直肠癌中表达升高,并与结直肠癌侵袭和淋巴结转移密切相关。SCC-S2在结直肠癌的发生发展中可能发挥着重要作用。

Objective

SCC-S2 was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells.However, the expression of SCCS2 and its biological roles in colorectal cancers have not been reported.The aim of this study is to investigate the expression and clinical significance of SCC-S2 in colorectal cancers.

Methods

The expression pattern of SCC-S2 in 136 colorectal cancer tissues was analyzed by immunohistochemistry.The statistic analysis was performed by SPSS 18.0.

Results

SCC-S2 was overexpressed in 67(49.26 %)of 136 colon cancer specimens.There was a significant association between SCC-S2 overexpression and TNM stage(P<0.01), lymph node metastasis(P<0.05), and proliferation index(P<0.01).

Conclusions

SCC-S2 is overexpressed in colorectal cancers and contributes to invasion and lymph node metastasis.SCC-S2 may play an important role as tumor-promoting factor in colorectal cancer.

图1 SCC-S2在肿瘤组织中免疫组织化学染色表达图像
表1 SCC-S2的表达与结肠癌的临床病理因素关系情况表
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