切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2015, Vol. 04 ›› Issue (01) : 58 -61. doi: 10.3877/cma.j.issn.2095-3224.2015.01.13

所属专题: 文献

论著

新型接头蛋白CARD10在结直肠癌中的表达与意义
赵婷婷1, 刑鹏1, 李继光1,()   
  1. 1. 110000 沈阳,中国医科大学肿瘤研究所
  • 收稿日期:2015-01-20 出版日期:2015-02-25
  • 通信作者: 李继光
  • 基金资助:
    国家自然科学基金(81302125)

Expression and the significance of caspase recruitment domain family member10 in colorectal cancer

Ting-ting ZHAO1, Peng XING1, Ji-guang LI1,()   

  1. 1. Tumor Research Institute of China Medical University, Shenyang 110013, China
  • Received:2015-01-20 Published:2015-02-25
  • Corresponding author: Ji-guang LI
  • About author:
    Corresponding author: LI Ji-guang, Email: .
引用本文:

赵婷婷, 刑鹏, 李继光. 新型接头蛋白CARD10在结直肠癌中的表达与意义[J/OL]. 中华结直肠疾病电子杂志, 2015, 04(01): 58-61.

Ting-ting ZHAO, Peng XING, Ji-guang LI. Expression and the significance of caspase recruitment domain family member10 in colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(01): 58-61.

目的

检测CARD10(caspase recruitment domain family member 10)蛋白在结直肠癌组织及其癌旁粘膜组织中的表达水平,结合临床病理资料,探讨CARD10与结直肠癌患者临床病理特征的关系。

方法

利用免疫组化方法检测147例结直肠癌组织及其癌旁粘膜组织中的CARD10表达情况,使用SPSS 19.0软件进行统计分析。

结果

在结直肠癌组织和癌旁黏膜组织中,CARD10阳性表达分别为46例(31.29%)和10例(6.80%),CARD10在结直肠癌中的表达上调(P<0.01)。CARD10在结直肠癌组织中的表达与肿瘤的TNM分期(P<0.01)、浸润深度(P<0.05)、淋巴结转移(P<0.01)、远处转移(P<0.05)以及Ki-67表达明显相关(P<0.01)。

结论

CARD10在结直肠癌的发生发展中可能发挥着肿瘤促进因子的作用。

Objective

To investigate the expression and the significance of CARD10(caspase recruitment domain family member 10)in colorectal cancer.

Methods

The expression of CARD10 was detected by immunohistochemistry.The statistic analysis was performed by SPSS 19.0.

Results

Overexpression of CARD10 was found in 46(31.29%)patients and 10(6.80%)patients in colorectal cancer tissues and tumor-adjacent mucosae, respectively.CARD10 was overexpressed in colorectal cancer(P<0.01). Overexpression of CARD10 in colorectal cancer correlated with TNM stage(P<0.01), tumor depth(P<0.05), nodal metastasis(P<0.01), distant metastasis(P<0.05), and Ki-67 status(P<0.01).

Conclusion

This study demonstrated that CARD10 may play a role as tumor-promoting factor in colorectal cancer.

表1 CARD10的表达与临床病理资料关系表
图1 CARD10在肿瘤组织中免疫组织化学染色图像
[1]
Siegel R, Naishadham D, Jemal A.Cancer statistics,2012.CA Cancer J Clin,2012,62:10-29.
[2]
Shostak K, Zhang X, Hubert P,et al.NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling.Nat Commun,2014,5:5232.
[3]
Luo Q, Lin H, Ye X,et al.Trim44 facilitates the migration and invasion of human lung cancer cells via the NF-kappaB signaling pathway.Int J ClinOncol,2014.
[4]
Ghonaimy EA, Shinawi M, Ibrahim SA,et al.Positive lymph-node breast cancer patients:Activation of NF-kappaB in tumor associated leukocytes stimulates cytokines secretion that promotes metastasis via CC-chemokine receptor CCR7.FEBS J,2014.
[5]
Ryan AE, Colleran A, O'Gorman A,et al.Targeting colon cancer cell NF-kappaB promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis.Oncogene,2014.
[6]
Schon S, Flierman I, Ofner A,et al.beta-catenin regulates NF-kappaB activity via TNFRSF19 in colorectal cancer cells.Int J Cancer,2014,135:1800-1811.
[7]
Dutta S, Wang FQ, Wu HS,et al.The NF-kappaB pathway mediates lysophosphatidic acid(LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer(EOC).GynecolOncol,2011,123:129-137.
[8]
Hwang YS, Hodge JC, Sivapurapu N,et al.Lysophosphatidic acid stimulates PC-3 prostate cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity.MolCarcinog,2006,45:518-529.
[9]
McAllister-Lucas LM, Inohara N, Lucas PC,et al.Bimp1,a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.J BiolChem,2001,276:30589-30597.
[10]
Grabiner BC, Blonska M, Lin PC,et al.CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.Genes Dev,2007,21:984-996.
[11]
Mahanivong C, Chen HM, Yee SW,et al.Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.Oncogene,2008,27:1273-1280.
[12]
Man X, He J, Kong C,et al.Clinical significance and biological roles of CARMA3 in human bladder carcinoma.TumourBiol,2014,35:4131-4136.
[13]
Du S, Jia L, Zhang Y,et al.CARMA3 is upregulated in human pancreatic carcinoma,and its depletion inhibits tumor proliferation,migration,and invasion.TumourBiol,2014,35:5965-5970.
[14]
Zhao T, Miao Z, Wang Z,et al.CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-kappaB regulation in breast cancer cells.TumourBiol,2013,34:3041-3047.
[15]
Chaturvedi MM, Sung B, Yadav VR,et al.NF-kappaB addiction and its role in cancer:'one size does not fit all'.Oncogene,2011,30:1615-1630.
[16]
Xie C, Han Y, Fu L,et al.Overexpression of CARMA3 is associated with advanced tumor stage,cell cycle progression,and cisplatin resistance in human epithelial ovarian cancer.TumourBiol,2014,35:7957-7964.
[17]
Lea D, Haland S, Hagland HR,et al.Accuracy of TNM staging in colorectal cancer:a review of current culprits,the modern role of morphology and stepping-stones for improvements in the molecular era.Scand J Gastroenterol,2014,49:1153-1163.
[18]
Costi R, Beggi F, Reggiani V,et al.Lymph node ratio improves TNM and Astler-Coller's assessment of colorectal cancer prognosis:an analysis of 761 node positive cases.J GastrointestSurg,2014,18:1824-1836.
[19]
Kulaylat AN, Schubart JR, Stokes AL,et al.Overall survival by pattern of recurrence following curative intent surgery for colorectal liver metastasis.J SurgOncol,2014,110:1011-1015.
[20]
Lumachi F, Orlando R, Marino F,et al.Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer.Anticancer Res,2012,32:3965-3967.
[1] 赵阳, 肖迎聪, 巨艳, 党晓智, 蔡林利, 薛文欣, 李洋, 肖瑶, 郭妤绮, 宋宏萍. 自动乳腺超声联合免疫组化早期预测乳腺癌新辅助化疗病理完全缓解的临床价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(04): 361-369.
[2] 罗青杉, 梅海涛, 郝家领, 蔡锦锋, 周润楷, 温玉刚. 连接蛋白43通过调控细胞周期抑制结直肠癌的增殖机制研究[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 344-349.
[3] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[4] 谢丽春, 欧庆芬, 张秋萍, 叶升. 简化和标准肝脏MRI方案在结直肠癌肝转移患者随访中的临床应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 434-437.
[5] 施烨鑫, 马翔, 鲁明, 夏青城, 王鹏超, 宋青雨, 赵庆洪. 腹腔镜下结直肠肿瘤定位研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 463-466.
[6] 韩加刚, 王振军. 梗阻性左半结肠癌的治疗策略[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 450-458.
[7] 梁轩豪, 李小荣, 李亮, 林昌伟. 肠梗阻支架置入术联合新辅助化疗治疗结直肠癌急性肠梗阻的疗效及其预后的Meta 分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 472-482.
[8] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[9] 赵磊, 刘文志, 林峰, 于剑, 孙铭骏, 崔佑刚, 张旭, 衣宇鹏, 于宝胜, 冯宁. 深部热疗在改善结直肠癌术后辅助化疗副反应及生活质量中的作用研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 488-493.
[10] 黄海洋, 邝永龙, 陈嘉胜. 基层医院结直肠肿瘤经自然腔道取标本手术30 例分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 510-518.
[11] 任佳琪, 刁德昌, 何自衍, 张雪阳, 唐新, 李文娟, 李洪明, 卢新泉, 易小江. 网膜融合线导向的脾曲游离技术在左半结肠癌根治术中的应用[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 362-367.
[12] 张迪, 王春霞, 张学东, 李发馨, 庞淅文, 陈一锋, 张维胜, 王涛. 梗阻性左半结直肠癌自膨式金属支架置入后行腹腔镜手术与开腹手术的短期临床疗效比较[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 375-380.
[13] 张蔚林, 王哲学, 白峻阁, 黄忠诚, 肖志刚. 利用TCGA数据库构建基于miRNA的结直肠癌列线图预后模型[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 381-388.
[14] 张伟伟, 陈启, 翁和语, 黄亮. 随机森林模型预测T1 期结直肠癌淋巴结转移的初步研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 389-393.
[15] 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
阅读次数
全文


摘要