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中华结直肠疾病电子杂志 ›› 2014, Vol. 03 ›› Issue (03) : 167 -171. doi: 10.3877/cma.j.issn.2095-3224.2014.03.02

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阿司匹林在结直肠癌防治中的意义
陈楠1, 李明1(), 顾晋1,()   
  1. 1. 100036,北京大学肿瘤医院 北京肿瘤医院暨北京市肿瘤防治研究所结直肠肿瘤外科 恶性肿瘤发病机制及转化研究教育部重点实验室
  • 收稿日期:2014-05-15 出版日期:2014-06-25
  • 通信作者: 李明, 顾晋

Aspirin in the prophylaxis and treatment of colorectal cancer

Nan CHEN1, Jin GU1,(), Ming LI1()   

  1. 1. Department of Colorectal Cancer Surgery, Beijing Cancer Hospital&Institute.Peking University Cancer Hospital, Peking University School of Oncology, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Beijing 100036, China
  • Received:2014-05-15 Published:2014-06-25
  • Corresponding author: Jin GU, Ming LI
  • About author:
    Corresponding author: GU Jin, Email:
引用本文:

陈楠, 李明, 顾晋. 阿司匹林在结直肠癌防治中的意义[J/OL]. 中华结直肠疾病电子杂志, 2014, 03(03): 167-171.

Nan CHEN, Jin GU, Ming LI. Aspirin in the prophylaxis and treatment of colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2014, 03(03): 167-171.

阿司匹林作为基础抗凝药物,在心血管疾病中已得到广泛应用。近20年来,随着结直肠癌发病率和死亡率的逐年升高,阿司匹林在结直肠癌患者中的应用和影响也逐渐受到关注。一些回顾性的临床研究发现规律服用阿司匹林的结直肠癌患者肿瘤特异生存率更高,且远隔转移率更低。在现有的抗结直肠癌药物(5-Fu、奥沙利铂、伊立替康和靶向药物)之外,阿司匹林是否也可能作为一种抗肿瘤药物应用于结直肠癌的预防和治疗一直成为学术界关注的热点问题。本文回顾了阿司匹林与结直肠癌相关的临床研究,尝试客观的分析阿司匹林在结直肠癌预防和辅助治疗中的作用及其局限性,以期为临床治疗和研究提供借鉴。

As a fundamental anti-platelet drug, aspirin has been widely administrated in the treatment of cardiovascular diseases.In the past 20 years, with the increasing incidence of colorectal cancer(CRC), there has been great concern on the role of aspirin in the treatment of CRC.Several retrospective clinical trails revealed that CRC patients with regular aspirin intake benefited from higher cancer specific survival and lower incidence of metastasis.Therefore, the question whether aspirin would be an effective anti-CRC drug in the primary prevention and adjuvant therapy, apart from 5-Fu, oxaliplatin, irinotecan and monoclonal antibodies is under intensive discussion.In this review, we aim to summarize recently published clinical trails and try to investigate the role of aspirin in CRC prevention and adjuvant therapy with its limitations for the guidance of clinical practice and future study.

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