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中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (05) : 458 -462. doi: 10.3877/cma.j.issn.2095-3224.2018.05.010

所属专题: 文献

论著

乙肝表面抗原等因素对结直肠癌肝转移的影响
孙丕杉1, 高玉熙2, 江凯2, 李硕2, 董蒨2, Zhuoli Zhang3, 卢云4,()   
  1. 1. 266000,青岛市城阳区人民医院心胸血管外科
    2. 266000,青岛大学附属医院胃肠外科
    3. Chicago,Illinois 60611,Department of Radiology,Feinberg School of Medicine
    4. 266000,青岛大学附属医院胃肠外科;266000 青岛,山东省数字医学与计算机辅助手术重点实验室
  • 收稿日期:2017-07-22 出版日期:2018-10-25
  • 通信作者: 卢云
  • 基金资助:
    国家"十二五"科技攻关项目(No.2013BAI01B03); 青岛市重大科技与技术专项(No.14-6-1-6-zdzx)

Effects of hepatitis B surface antigen and other factors on liver metastasis of colorectal

Pishan Sun1, Yuxi Gao2, Kai Jiang2, Shuo Li2, Qian Dong2, Zhuoli Zhang3, Yun Lu4,()   

  1. 1. Department of Heart Vascular Surgery, Qingdao Chengyang People′s Hospital, Qingdao 266000, China
    2. Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, China
    3. Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    4. Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, China; Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, Qingdao 266000, China
  • Received:2017-07-22 Published:2018-10-25
  • Corresponding author: Yun Lu
  • About author:
    Corresponding author: Lu Yun, Email:
引用本文:

孙丕杉, 高玉熙, 江凯, 李硕, 董蒨, Zhuoli Zhang, 卢云. 乙肝表面抗原等因素对结直肠癌肝转移的影响[J/OL]. 中华结直肠疾病电子杂志, 2018, 07(05): 458-462.

Pishan Sun, Yuxi Gao, Kai Jiang, Shuo Li, Qian Dong, Zhuoli Zhang, Yun Lu. Effects of hepatitis B surface antigen and other factors on liver metastasis of colorectal[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(05): 458-462.

目的

本研究将探讨乙肝表面抗原(HBsAg)等多项临床因素对结直肠癌肝转移的影响,为进一步治疗结直肠癌肝转移提供新的研究思路及方向。

方法

回顾性分析青岛大学医学院附属医院2010年1月至2011年6月病理证明的结直肠癌患者892例。收集患者的相关临床资料(包括乙肝表面抗原、年龄、术前相关实验室检查、术后病理结果等),研究是否会影响肝转移的发生。

结果

结直肠癌是否发生肝转移两组患者在性别、年龄、肿瘤发生部位、大小、病理组织类型、是否造口、血清白蛋白、总胆红素及谷草转氨酶等方面相比,差异均无统计学意义(χ2=0.359,Z=-1.631,χ2=0.003,χ2=1.223,χ2=0.619,χ2=0.516,Z=-3.235,Z=-0.106,Z=-0.328;均P>0.05)。HBsAg阳性较阴性患者发生肝转移几率明显降低,差异有统计学意义(χ2=5.809,P<0.05)。另外,肝转移与分化水平(χ2=14.165,P<0.01)、浸润程度(χ2=17.808,P<0.01)以及淋巴结转移数目(χ2=41.798,P<0.01)有关,差异均有统计学意义。多因素logistic回归分析结果表示乙肝病毒表面阳性患者肝转移发生低,而低分化、浸润程度高、淋巴结转移多者肝转移率高。

结论

乙型肝炎病毒表面抗原阳性会降低肝转移的发生几率。分化程度越低、浸润程度越高、淋巴结转移数多,越容易发生肝转移。

Objective

The study will explore the effect of HBsAg and other clinical factors on liver metastasis of colorectal cancer, and provide new research ideas and direction for further treatment of liver metastasis of colorectal cancer.

Methods

Retrospective analysis of Affiliated Hospital of Qingdao University Medical College in January 2010 to June 2011 with pathology confirmed 892 cases of colorectal cancer patients. The clinical data (including hepatitis B surface antigen, age, preoperative related laboratory examination, postoperative pathological results) were collected to determine whether the incidence of liver metastasis was affected.

Results

There was no statistically significant difference compared to two groups of gender age, tumor location, tumor size, histological type, whether the stoma, serum albumin, serum bilirubin, ALP (χ2=0.359, Z=-1.631, χ2=0.003, χ2=1.223, χ2=0.619, χ2=0.516, Z=-3.235, Z=-0.106, Z=-0.328; P>0.05). HBsAg positive patients can significantly reduce the incidence of liver metastasis than negative patients, there was a significant statistical difference (χ2=5.809, P<0.05). In addition, the degree of liver metastasis and differentiation (χ2=14.165, P<0.01), the degree of infiltration (χ2=17.808, P<0.01) and the number of lymph node metastasis (χ2=41.798, P<0.01) , the difference was statistically significant. Multivariate logistic regression analysis showed that hepatitis B virus-positive patients with liver metastasis occurred low, and poorly differentiated, high degree of invasion, lymph node metastasis and high liver metastases.

Conclusion

Hepatitis B virus surface antigen positive will reduce the incidence of liver metastases. The lower degree of differentiation, the higher degree of infiltration, the number of lymph node metastasis, are the factors more prone to liver metastasis.

表1 不同临床资料与肝转移之间的关系(例)
表2 肝转移与HBsAg之间的关系(例)
表3 年龄、术前生化检查和肿瘤标记与肝转移之间关系(±s
表4 肝转移影响因素的多元Logistic回归分析
[1]
Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012 [J]. CA Cancer J Clin, 2015, 65(2):87-108.
[2]
Foster JH. Treatment of metastatic disease of the liver: a skeptic′s view [J]. Semin Liver Dis, 1984, 4(2):170-179.
[3]
Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal metastases [J]. J Clin Oncol, 1997, 15(3):938-946.
[4]
Psaila B, Lyden D. The metastatic niche: adapting the foreign soil [J]. Nat Rev Cancer, 2009, 9(4):285-293.
[5]
Morgan SC, Parker CC. Local treatment of metastatic cancer-killing the seed or disturbing the soil? [J] .Nat Rev ClinOncol, 2011, 8(8):504-506.
[6]
Lisa JR, Solomon C, Gordon EJ. Secondary Carcinoma in Cirrhosis of the Liver [J]. Am J Pathol, 1942, 18(1):137-140.
[7]
Hamaya K, Hashimoto H, Maeda Y. Metastatic carcinoma in cirrhotic liver-Statistical survey of autopsies in Japan [J]. Acta Pathol Jpn, 1975, 25(2):153-159.
[8]
李皇保,钱立元,马冬.结直肠癌肝转移与乙肝、肝硬化、脂肪肝的临床分析[J].中国现代医学杂志, 2011, 21(9):1122-1125.
[9]
Lara-Pezzi E,Majano PL,Gomez-Gonzalo M, et al. Thehepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes [J]. Hepatology, 1998, 28(4):1013-1021.
[10]
Wu FL, Jin WB, Li JH, et al. Targets for human encoded microRNAs in HBV genes [J].Virus Genes, 2011, 42(2):157-161.
[11]
Wang Y, Jiang L, Ji X, et al. Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes [J]. J Biol Chem, 2013, 288(25):18484-18493.
[12]
Song E, Chen J, Ou Q, et al. Rare occurrence of metastatic colorectal cancers in livers with replicative hepatitis B infection [J]. Am J Surg, 2001, 181(6):529-533.
[13]
Qian HG, Hao CY. Hepatitis B virus infection is an independent factor influencing the occurrence of liver metastasis in colorectal cancer: a retrospective analysis of 1413 cases [J]. Hepatogastroenterology, 2014, 61(135):1908-1914.
[14]
钱红纲,张霁,冷家骅, 等. 乙型肝炎病毒感染及肝硬化与结直肠癌肝转移的关系[J].中华胃肠外科杂志, 2010, 13(3):202-204.
[15]
Qiu HB, Zhang LY, Zeng ZL, et al.HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study [J].World J Gastroenterol, 2011, 17(6):804-808.
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