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中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (02) : 102 -107. doi: 10.3877/cma.j.issn.2095-3224.2017.02.004

所属专题: 文献

论著

结直肠癌患者饮食结构特征及与健康人群的差异分析
高仁元1, 吴磊2, 黄林生1, 潘成1, 尹明明1, 李豪1, 孔程1, 沈蓉蓉1, 张鹏1, 秦环龙1,()   
  1. 1. 200072 上海,同济大学附属第十人民医院普外科
    2. 201908 上海市罗店医院普外科
  • 收稿日期:2016-11-25 出版日期:2017-04-25
  • 通信作者: 秦环龙
  • 基金资助:
    国家自然科学基金资助项目(No.81230057;No.81472262;No.81302066); 上海市市级医院新兴前沿技术联合攻关项目(No.SHDC12012106)

Diet pattern characterization and analysis between colorectal cancer patients and healthy volunteers

Renyuan Gao1, Lei Wu2, Linsheng Huang1, Cheng Pan1, Mingming Yin1, Hao Li1, Cheng Kong1, Rongrong Shen1, Peng Zhang1, Huanlong Qin1,()   

  1. 1. Department of General Surgery, Shanghai Tenth People Hospital affiliated to Tongji University School of Medicine, Shanghai 200072, China
    2. Department of General Surgery, Shanghai Luodian Hospital, Shanghai 201908, China
  • Received:2016-11-25 Published:2017-04-25
  • Corresponding author: Huanlong Qin
  • About author:
    Corresponding author: Qin Huanlong, Email:
引用本文:

高仁元, 吴磊, 黄林生, 潘成, 尹明明, 李豪, 孔程, 沈蓉蓉, 张鹏, 秦环龙. 结直肠癌患者饮食结构特征及与健康人群的差异分析[J/OL]. 中华结直肠疾病电子杂志, 2017, 06(02): 102-107.

Renyuan Gao, Lei Wu, Linsheng Huang, Cheng Pan, Mingming Yin, Hao Li, Cheng Kong, Rongrong Shen, Peng Zhang, Huanlong Qin. Diet pattern characterization and analysis between colorectal cancer patients and healthy volunteers[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(02): 102-107.

目的

研究结直肠癌患者与健康人群的饮食结构差异。

方法

采用饮食频次调查表收集40例肠癌患者和72例正常人群饮食信息,根据饮食成分表各食物营养成分,使用Mann-Whitney U检验计算宏量营养素和微量营养素摄入量,分析二者之间的差异。

结果

结直肠癌患者能量摄入量显著高于健康人群(Z=-2.836,P=0.005),碳水化合物和脂肪的摄入量也显著高于对照组人群(Z=-2.065,P=0.018;Z=-2.368,P=0.039)。此外,微量元素中胡萝卜素、硫胺素、核黄素以及维生素E也显著高于对照组人群。经过年龄和性别校正后,不同水平脂肪的摄入量与结直肠癌具有相关性(Wald=9.658,P=0.02)。

结论

结直肠癌患者饮食结构与健康人群有显著差异,特别是以高能量、高蛋白和高脂肪为特点,而关于脂肪摄入量与结直肠癌的风险则需要更大样本量研究。

Objective

To study the difference of diet pattern between colorectal cancer patients and healthy volunteer.

Methods

Food Frequency Questionnaire was applied to obtain the diet data of 40 colorectal cancer patients and 72 healthy volunteers. Then daily intake of macronutrients and micronutrients were calculated and compared between the two groups.

Results

The energy intake was significantly higher in colorectal cancer patients than the healthy volunteers (Z=-2.836, P=0.005), the intake of protein and carbohydrates in the colorectal cancer patients were also significant high than the healthy (Z=-2.065, P=0.018; Z=-2.368, P=0.039). In addition, colorectal cancer patients also took more carotene, thiamine, riboflavin than healthy volunteers. And after adjustment for age and gender, fat intake with different intake amounts was associated with colorectal cancer (Wald=9.658, P=0.02).

Conclusion

The diet pattern of colorectal cancer patients, which characterized by high intake of energy, protein and fat, was significant different from healthy volunteers. However, in terms of the relationship between fat intake and colorectal cancer risk, it is still needed a large sample size survey.

表1 研究人群的基本信息
表2 研究对象的宏量及微量营养素摄入量(中位数,四分位数Q1,Q3)
表3 研究对象摄入营养素的四分位数及疾病比值比
? Q1 Q2 Q3 Q4 P
摄入能量(千卡/天) 857.3 1 245.1 1 659.8 2 335.9 ?
肠癌/对照例数 5/23 9/19 12/16 14/14 ?
Wald值 1 1.490 3.939 6.028 ?
OR值 1 2.18(0.62,7.61) 3.45(1.02,11.72) 4.60(1.36,15.55) 0.08
Wald值 1 1.017 2.666 4.958 ?
校正OR值 1 2.04(0.51,8.19) 3.24(0.79,13.24) 5.07(1.21,21.12) 0.15
蛋白质(克/天) 35.34 48.43 67.04 98.08 ?
肠癌/对照例数 9/19 5/23 14/14 12/16 ?
Wald值 1 1.490 1.821 0.682 ?
OR值 1 0.46(0.13~1.60) 2.11(0.71~6.25) 1.58(0.53~4.71) 0.08
Wald值 1 1.374 0.960 0.427 ?
校正OR值 1 0.43(0.11~1.76) 1.85(0.54~6.34) 1.55(0.42~5.70) 0.17
脂肪(克/天) 22.91 39.91 56.48 87.03 ?
肠癌/对照例数 9/19 4/24 11/17 16/12 ?
Wald值 1 2.396 0.310 3.460 ?
OR值 1 0.35(0.09~1.32) 1.37(0.46~4.09) 2.82(0.95~8.38) 0.02
Wald值 1 2.730 0.003 2.765 ?
校正OR值 1 0.30(0.07~1.25) 0.97(0.28~3.40) 2.85(0.83~9.82) 0.02
碳水化合物(克/天) 110.11 159.91 211.48 287.17 ?
肠癌/对照例数 5/23 10/18 15/13 10/18 ?
Wald值 1 2.206 7.198 2.206 ?
OR值 1 2.56(0.74~8.81) 5.31(1.57~17.97) 2.56(0.74~8.81) 0.06
Wald值 1 1.213 3.113 1.939 ?
校正OR值 1 2.13(0.56~8.16) 3.33(0.88~12.65) 2.61(0.68~10.07) 0.35
不溶性纤维(克/天) 5.10 8.87 11.98 20.34 ?
肠癌/对照例数 9/19 11/17 10/18 10/18 ?
Wald值 1 0.310 0.080 0.080 ?
OR值 1 1.37(0.46~4.09) 1.17(0.39~3.55) 1.17(0.39~3.55) 0.96
Wald值 1 1.050 0.006 1.814 ?
校正OR值 1 1.95(0.55~6.95) 0.95(0.26~3.47) 2.44(0.67~8.92) 0.44
钙(毫克/天) 350.20 490.10 603.66 894.72 ?
肠癌/对照例数 6/22 12/16 9/19 13/15 ?
Wald值 1 2.859 0.811 3.758 ?
OR值 1 2.75(0.85~8.88) 1.74(0.52~5.78) 3.18(0.99~10.23) 0.21
Wald值 1 2.730 0.003 2.765 ?
校正OR值 1 2.65(0.75~9.43) 1.41(0.37~5.39) 2.66(0.71~9.95) 0.35
图1 对饮食中所有营养素进行主成分分析碎石图
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