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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (01) : 67 -71. doi: 10.3877/cma.j.issn.2095-3224.2026.01.007

综述

肠道微生态疗法在结直肠肿瘤治疗中的应用
何睿1, 刘昀坤1, 孙陈,2,3(), 田宏亮,2,3,4,5()   
  1. 1200000 上海,同济大学医学院
    2200000 上海,同济大学附属第十人民医院普外科功能肠道外科
    3200000 上海市肠道微生态研究中心
    4233000 蚌埠市第一人民医院胃肠外科
    5232001 淮南,安徽理工大学第一临床医学院
  • 收稿日期:2025-10-28 出版日期:2026-02-25
  • 通信作者: 孙陈, 田宏亮
  • 基金资助:
    国家自然科学基金项目(No. 82100698); 蚌埠市卫健委重点项目(No. BBWK2024B101)

The application of intestinal microecological therapy in the treatment of colorectal tumors

Rui He1, Yunkun Liu1, Chen Sun,2,3(), Hongliang Tian,2,3,4,5()   

  1. 1Tongji University School of Medicine, Shanghai 200000, China
    2Department of Functional Intestinal Diseases, General Surgery of Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200000, China
    3Shanghai Gastrointestinal Microecology Research Center, Shanghai 200000, China
    4Department of Gastrointestinal Surgery, Bengbu First People’s Hospital, Bengbu 233000, China
    5First School of Clinical Medicine, Anhui University of Science and Technology, Huainan 232001, China
  • Received:2025-10-28 Published:2026-02-25
  • Corresponding author: Chen Sun, Hongliang Tian
引用本文:

何睿, 刘昀坤, 孙陈, 田宏亮. 肠道微生态疗法在结直肠肿瘤治疗中的应用[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(01): 67-71.

Rui He, Yunkun Liu, Chen Sun, Hongliang Tian. The application of intestinal microecological therapy in the treatment of colorectal tumors[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(01): 67-71.

研究表明,肠道菌群的失衡与结直肠癌的发生密切相关,这为微生态干预提供了理论基础。益生菌、益生元及合生元通过调节菌群组成、改善黏膜环境和抑制炎症反应,展现出辅助治疗潜力。部分特定菌株及其代谢产物可经受体-信号轴直接调控肿瘤进程,为靶向干预提供依据。近年来,工程菌、噬菌体疗法以及菌体代谢物的补充或拮抗策略不断发展,并在早期研究中显示良好的安全性与可行性。虽然存在个体差异、长期疗效及标准化不足等挑战,但基于多组学和精准医学的多维微生态疗法仍有望成为结直肠癌综合治疗的重要方向。

Accumulating evidence indicates that gut microbiota dysbiosis is closely associated with the development of colorectal cancer, providing a theoretical basis for microbiota-based interventions. Probiotics, prebiotics, and synbiotics exhibit adjunctive therapeutic potential by modulating microbial composition, improving the mucosal environment, and suppressing inflammation. Certain bacterial strains and their metabolites can directly regulate tumor progression through receptor–signaling pathways, offering a rationale for targeted modulation. In recent years, engineered bacteria, phage therapy, and strategies involving supplementation or antagonism of microbial metabolites have been rapidly advanced, showing promising safety and feasibility in early studies. Despite persistent challenges such as individual variability, limited long-term efficacy, and lack of standardization, multidimensional microbiota-based therapies guided by multi-omics and precision medicine are expected to become an important component of comprehensive colorectal cancer management.

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