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中华结直肠疾病电子杂志 ›› 2022, Vol. 11 ›› Issue (01) : 65 -69. doi: 10.3877/cma.j.issn.2095-3224.2022.01.010

综述

长链非编码RNA在结直肠癌中的研究进展
朱亿豪1, 汤庆超1,()   
  1. 1. 150081 哈尔滨医科大学附属第二医院结直肠肿瘤外科
  • 收稿日期:2021-01-01 出版日期:2022-02-25
  • 通信作者: 汤庆超
  • 基金资助:
    吴阶平医学基金会(320.2710.1849)

Research progress of long non-coding RNA in colorectal cancer

Yihao Zhu1, Qingchao Tang1,()   

  1. 1. Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
  • Received:2021-01-01 Published:2022-02-25
  • Corresponding author: Qingchao Tang
引用本文:

朱亿豪, 汤庆超. 长链非编码RNA在结直肠癌中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2022, 11(01): 65-69.

Yihao Zhu, Qingchao Tang. Research progress of long non-coding RNA in colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2022, 11(01): 65-69.

长链非编码RNA(LncRNA)是近十年来肿瘤领域分子机制研究的热点之一,被证实在生物体内对基因的表达具有调控作用,与肿瘤的发生与发展密切相关。结直肠癌是一种严重危害人类健康的恶性肿瘤,研究发现许多LncRNA在结直肠癌中表达失调。异常表达的LncRNA作为关键的调控因子,参与了多种生物学过程,影响肿瘤细胞的增殖和凋亡、侵袭转移及调节肿瘤耐药。研究LncRNA在肠癌中的作用机制可以为结直肠癌临床治疗提供一些新思路。此外,LncRNA还可作为一种潜在的生物标志物用于结直肠癌早期诊断及预后评估。

Long non-coding RNA has been one of the hot topics in the field of tumor molecular mechanism research in recent ten years. It has been proved that it regulates gene expression in organism, which is closely related to the occurrence and development of tumor. Colorectal cancer is a kind of malignant tumor that seriously harms people's health. Studies have found that the expression of LncRNA is dysregulated in colorectal cancer, and the abnormally expressed LncRNA, as a key regulatory factor, can participate in a variety of biological processes, affecting the proliferation and apoptosis of tumor cells, invasion and metastasis, and the regulation of tumor drug resistance, providing a new idea for the clinical treatment of colorectal cancer. In addition, LncRNA can also be used as a potential biomarker for early diagnosis and prognosis assessment of colorectal cancer.

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