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中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (06) : 458 -462. doi: 10.3877/cma.j.issn.2095-3224.2017.06.004

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腹腔热灌注化疗在结直肠肿瘤腹膜转移中的应用
王治杰1, 刘骞1,()   
  1. 1. 100021 北京,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科
  • 收稿日期:2017-10-27 出版日期:2017-12-25
  • 通信作者: 刘骞
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(No.2017-12M-1-006); 中国医学科学院肿瘤医院联合攻关项目(No.LC2017L03)

Application of hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis of colorectal cancer

Zhijie Wang1, Qian Liu1,()   

  1. 1. Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2017-10-27 Published:2017-12-25
  • Corresponding author: Qian Liu
  • About author:
    Corresponding author: Liu Qian, Email:
引用本文:

王治杰, 刘骞. 腹腔热灌注化疗在结直肠肿瘤腹膜转移中的应用[J/OL]. 中华结直肠疾病电子杂志, 2017, 06(06): 458-462.

Zhijie Wang, Qian Liu. Application of hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis of colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(06): 458-462.

腹膜是结直肠癌的常见转移部位,一旦出现,患者预后极差。传统的观念认为腹膜转移为结直肠癌的远处转移,出现则为Ⅳ期,只能接受姑息治疗。然而,越来越多的学者认为单纯的腹膜转移可以被认为是一种局部病变,可以采用更为积极的治疗方式,如腹膜切除,腹腔热灌注化疗等。多项临床研究已证实,相对于传统的姑息手术与系统化疗,肿瘤细胞减灭术联合腹腔热灌注化疗显著改善了患者的预后,延长了生存期。但是目前尚无统一的患者选择标准、治疗流程、化疗方案等,影响了腹腔热灌注化疗的整体疗效,阻碍了其临床应用推广,因此仍需更多的临床应用研究来获得高级别的循证医学证据,来规范腹腔热灌注化疗的临床应用。

Peritoneum is a common site of colorectal tumor metastasis. Patients with colorectal cancer who are diagnosed with peritoneum metastasis have extremely bad prognosis. Traditionally, peritoneum metastasis is regarded as a distant metastasis of colorectal cancer and classified as IV stage, which can only receive palliative treatment. However, more and more specialists gradually consider simple peritoneal carcinomatosis as a local regional disease, thus more aggressive treatment modality can be adopted, including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Multiple clinical trials have verified combination of CRS and HIPEC can dramatically improve prognosis and overall survival of patients compared to palliative surgery and systematic chemotherapy. However, the absence of a unified criterion for patients selection and treatment protocol gets in the way of the application of HIPEC, which still needs many clinical trials to make a standard guideline.

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