切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 420 -425. doi: 10.3877/cma.j.issn.2095-3224.2023.05.009

综述

Her-2阳性结直肠癌的诊治进展
吴寅, 陈智琴, 高勇, 权明()   
  1. 200123 上海,同济大学附属东方医院肿瘤科
  • 收稿日期:2022-10-06 出版日期:2023-10-25
  • 通信作者: 权明
  • 基金资助:
    国家自然科学基金(81972280); 上海市医苑新星青年医学人才培养计划; 上海市浦东新区临床高峰学科(PWYgf2021-07)

Progress in diagnosis and treatment of Her-2 positive colorectal cancer

Yin Wu, Zhiqin Chen, Yong Gao, Ming Quan()   

  1. Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200123, China
  • Received:2022-10-06 Published:2023-10-25
  • Corresponding author: Ming Quan
引用本文:

吴寅, 陈智琴, 高勇, 权明. Her-2阳性结直肠癌的诊治进展[J/OL]. 中华结直肠疾病电子杂志, 2023, 12(05): 420-425.

Yin Wu, Zhiqin Chen, Yong Gao, Ming Quan. Progress in diagnosis and treatment of Her-2 positive colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(05): 420-425.

结直肠癌是最常见的消化道恶性肿瘤之一,近年来随着精准治疗理念的提出及精准诊断技术的改进,关于Her-2阳性的结直肠癌逐步引起学者的关注。Her-2阳性结直肠癌总体约占5%,包括Her-2过表达,ERBB2基因扩增及突变。目前对于标准治疗失败的Her-2过表达或扩增的结直肠癌患者已有诸多研究证实靶向Her-2治疗的可行性,但Her-2突变型患者目前尚无确切可行的治疗策略。笔者就近年来Her-2阳性结直肠癌的诊治进展作一概述。

Colorectal cancer is one of the most common malignant tumors of digestive tract. In recent years, with the introduction of the concept of precision treatment and the improvement of precision diagnosis technology, scholars have gradually paid attention to Her-2 positive colorectal cancer, which accounts for about 5%, including Her-2 overexpression, ERBB2 gene amplification and mutation. At present, many studies have confirmed the feasibility of targeting Her-2 in colorectal cancer patients with overexpression or amplification of Her-2 that fail to receive standard treatment, but there is no definite and feasible treatment strategy for Her-2 mutant patients. This article reviews the progress in the diagnosis and treatment of Her-2 positive colorectal cancer in recent years.

表1 Her-2阳性结直肠癌临床研究汇总
图1 结直肠癌ERBB2常见突变位点分析
图2 Her-2阳性结直肠癌的诊断标准及治疗策略
[1]
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2021, 71(3): 209-249.
[2]
Qiu H, Cao S, Xu R. Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020[J]. Cancer Commun (Lond), 2021, 41(10): 1037-1048.
[3]
Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(3): 145-164.
[4]
Rosati G, Aprile G, Colombo A, et al. Colorectal cancer heterogeneity and the impact on precision medicine and therapy efficacy[J]. Biomedicines, 2022, 10(5): 1035.
[5]
Zhuo X, Guo H, Ma J, et al. Clinical characteristics and prognostic factors of patients with non-small cell lung cancer having HER2 alterations[J]. J Cancer Res Clin Oncol, 2023, 149(5): 2029-2039.
[6]
Zhou C, Li X, Wang Q, et al. Pyrotinib in HER2-mutant advanced lung adenocarcinoma after platinum-based chemotherapy: a multicenter, open-label, single-arm, phase Ⅱ study[J]. J Clin Oncol, 2020, 38(24): 2753-2761.
[7]
Gan K, Gao Y, Liu K, et al. The clinical significance and prognostic value of HER2 expression in bladder cancer: a meta-analysis and a bioinformatic analysis[J]. Frontiers in Oncology, 2021, 11: 653491.
[8]
Siena S, Sartore-Bianchi A, Marsoni S, et al. Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer[J]. Ann Oncol, 2018, 29(5): 1108-1119.
[9]
Ross JS, Fakih M, Ali SM, et al. Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3[J]. Cancer, 2018, 124(7): 1358-1373.
[10]
Chen Z, Chen J, Gao Y, et al. Heterogeneous clinical and pathological landscapes of HER2 positive colorectal cancer[J]. Expert Rev Anticancer Ther, 2021, 21(10): 1097-1104.
[11]
Gao M, Jiang T, Li P, et al. Efficacy and safety of HER2-targeted inhibitors for metastatic colorectal cancer with HER2-amplified: A meta-analysis[J]. Pharmacol Res, 2022, 182: 106330.
[12]
Strickler JH, Yoshino T, Graham RP, et al. Diagnosis and treatment of ERBB2-positive metastatic colorectal cancer: a review[J]. JAMA Oncology, 2022, 8(5): 760-769.
[13]
Meric-Bernstam F, Hurwitz H, Raghav KPS, et al. Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study[J]. Lancet Oncol, 2019, 20(4): 518-530.
[14]
Nakamura Y, Okamoto W, Kato T, et al. TRIUMPH: Primary efficacy of a phase Ⅱ trial of trastuzumab (T) and pertuzumab (P) in patients (pts) with metastatic colorectal cancer (mCRC) with HER2 (ERBB2) amplification (amp) in tumour tissue or circulating tumour DNA (ctDNA): A GOZILA sub-study[J]. Ann Oncol, 2019, 30: v199-v200.
[15]
Strickler JH, Zemla T, Ou FS, et al. Trastuzumab and tucatinib for the treatment of HER2 amplified metastatic colorectal cancer (mCRC): Initial results from the MOUNTAINEER trial[J]. Ann Oncol, 2019, 30: v200.
[16]
Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial[J]. Lancet Oncol, 2016, 17(6): 738-746.
[17]
Sartore-Bianchi A, Lonardi S, Martino C, et al. Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial[J]. ESMO Open, 2020, 5(5): e000911.
[18]
Siena S, Di Bartolomeo M, Raghav K, et al. Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial[J]. Lancet Oncol, 2021, 22(6): 779-789.
[19]
Nakamura Y, Sawada K, Fujii S, et al. HER2-targeted therapy should be shifted towards an earlier line for patients with anti-EGFR-therapy naïve, HER2-amplified metastatic colorectal cancer[J]. ESMO Open, 2019, 4(3): e000530.
[20]
Cen S, Liu Z, Pan H, et al. Clinicopathologic features and treatment advances in cancers with HER2 alterations[J]. Biochim Biophys Acta Rev Cancer, 2021, 1876(2): 188605.
[21]
El-Deiry WS, Goldberg RM, Lenz HJ, et al. The current state of molecular testing in the treatment of patients with solid tumors, 2019[J]. CA Cancer J Clin, 2019, 69(4): 305-343.
[22]
Robichaux JP, Elamin YY, Vijayan RSK, et al. Pan-cancer landscape and analysis of ERBB2 mutations identifies poziotinib as a clinically active inhibitor and enhancer of T-DM1 activity[J]. Cancer Cell, 2019, 36(4): 444-457. e447.
[23]
Guarini C, Grassi T, Pezzicoli G, et al. Beyond RAS and BRAF: HER2, a new actionable oncotarget in advanced colorectal cancer[J]. Int J Mol Sci, 2021, 22(13): 6813.
[24]
Sun SJ, Lin Q, Sun Q, et al. High HER-2 protein levels correlate with clinicopathological features in colorectal cancer[J]. J Cancer Res Ther, 2016, 12(1): 323-333.
[25]
Wang G, He Y, Sun Y, et al. Prevalence, prognosis and predictive status of HER2 amplification in anti-EGFR-resistant metastatic colorectal cancer[J]. Clin Transl Oncol, 2020, 22(6): 813-822.
[26]
Li QH, Wang YZ, Tu J, et al. Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance[J]. Gastroenterol Rep (Oxf), 2020, 8(3): 179-191.
[27]
Sartore-Bianchi A, Amatu A, Porcu L, et al. HER2 positivity predicts unresponsiveness to EGFR-targeted treatment in metastatic colorectal cancer[J]. The Oncologist, 2019, 24(10): 1395-1402.
[28]
Sawada K, Nakamura Y, Yamanaka T, et al. Prognostic and predictive value of HER2 amplification in patients with metastatic colorectal cancer[J]. Clin Colorectal Cancer, 2018, 17(3): 198-205.
[29]
Jeong JH, Kim J, Hong YS, et al. HER2 amplification and cetuximab efficacy in patients with metastatic colorectal cancer harboring wild-type RAS and BRAF[J]. Clin Colorectal Cancer, 2017, 16(3): e147-e152.
[30]
Kavuri SM, Jain N, Galimi F, et al. HER2 activating mutations are targets for colorectal cancer treatment[J]. Cancer Discovery, 2015, 5(8): 832-841.
[31]
De Cuyper A, Van Den Eynde M, Machiels JP. HER2 as a predictive biomarker and treatment target in colorectal cancer[J]. Clin Colorectal Cancer, 2020, 19(2): 65-72.
[32]
Laurent-Puig P, Balogoun R, Cayre A, et al. ERBB2 alterations a new prognostic biomarker in stage III colon cancer from a FOLFOX based adjuvant trial (PETACC8)[J]. Ann Oncol, 2016, 27(Suppl. 6): vi151.
[33]
Richman SD, Southward K, Chambers P, et al. HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3 256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials[J]. J Pathol, 2016, 238(4): 562-570.
[34]
Ma CX, Bose R, Gao F, et al. Neratinib efficacy and circulating tumor DNA detection of HER2 mutations in HER2 nonamplified metastatic breast cancer[J]. Clin Cancer Res, 2017, 23(19): 5687-5695.
[35]
Oaknin A, Friedman CF, Roman LD, et al. Neratinib in patients with HER2-mutant, metastatic cervical cancer: findings from the phase 2 SUMMIT basket trial[J]. Gynecol Oncol, 2020, 159(1): 150-156.
[36]
Iwama E, Zenke Y, Sugawara S, et al. Trastuzumab emtansine for patients with non-small cell lung cancer positive for human epidermal growth factor receptor 2 exon-20 insertion mutations[J]. Eur J Cancer, 2022, 162: 99-106.
[37]
Le X, Cornelissen R, Garassino M, et al. Poziotinib in non-small-cell lung cancer harboring HER2 exon 20 insertion mutations after prior therapies: ZENITH20-2 trial[J]. J Clin Oncol, 2022, 40(7): 710-718.
[38]
Mazieres J, Lafitte C, Ricordel C, et al. Combination of trastuzumab, pertuzumab, and docetaxel in patients with advanced non-small-cell lung cancer harboring HER2 mutations: results from the IFCT-1703 R2D2 trial[J]. J Clin Oncol, 2022, 40(7): 719-728.
[39]
Wang C, Fakih M. Response to trastuzumab and lapatinib in a metastatic colorectal cancer harboring HER2 amplification and HER2 S310F mutation[J]. J Natl Compr Canc Netw, 2021, 19(6): 670-674.
[1] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[2] 罗青杉, 梅海涛, 郝家领, 蔡锦锋, 周润楷, 温玉刚. 连接蛋白43通过调控细胞周期抑制结直肠癌的增殖机制研究[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 344-349.
[3] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[4] 吴伟宙, 王琼仁, 詹雄宇, 郑明星, 李亚县. 广东省医学会泌尿外科疑难病例多学科会诊(第16期)——左肾肉瘤样癌[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 525-529.
[5] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[6] 魏妙艳, 徐近. 合并远处转移胰腺癌系统性治疗的梳理和展望[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 644-650.
[7] 韩加刚, 王振军. 梗阻性左半结肠癌的治疗策略[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 450-458.
[8] 梁轩豪, 李小荣, 李亮, 林昌伟. 肠梗阻支架置入术联合新辅助化疗治疗结直肠癌急性肠梗阻的疗效及其预后的Meta 分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 472-482.
[9] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[10] 赵磊, 刘文志, 林峰, 于剑, 孙铭骏, 崔佑刚, 张旭, 衣宇鹏, 于宝胜, 冯宁. 深部热疗在改善结直肠癌术后辅助化疗副反应及生活质量中的作用研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 488-493.
[11] 黄海洋, 邝永龙, 陈嘉胜. 基层医院结直肠肿瘤经自然腔道取标本手术30 例分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 510-518.
[12] 任佳琪, 刁德昌, 何自衍, 张雪阳, 唐新, 李文娟, 李洪明, 卢新泉, 易小江. 网膜融合线导向的脾曲游离技术在左半结肠癌根治术中的应用[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 362-367.
[13] 张迪, 王春霞, 张学东, 李发馨, 庞淅文, 陈一锋, 张维胜, 王涛. 梗阻性左半结直肠癌自膨式金属支架置入后行腹腔镜手术与开腹手术的短期临床疗效比较[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 375-380.
[14] 张蔚林, 王哲学, 白峻阁, 黄忠诚, 肖志刚. 利用TCGA数据库构建基于miRNA的结直肠癌列线图预后模型[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 381-388.
[15] 张伟伟, 陈启, 翁和语, 黄亮. 随机森林模型预测T1 期结直肠癌淋巴结转移的初步研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 389-393.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?