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中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (03) : 207 -213. doi: 10.3877/cma.j.issn.2095-3224.2018.03.002

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青年专家论坛

微卫星状态对结肠癌术后辅助化疗决策的影响
王畅1,()   
  1. 1. 130021 吉林大学第一医院肿瘤中心
  • 收稿日期:2017-08-27 出版日期:2018-06-25
  • 通信作者: 王畅

The impact of microsatellite status on decision-making of adjuvant chemotherapy in colon cancer

Chang Wang1,()   

  1. 1. Cancer Center of The First Hospital of Jilin University, Changchun 130021, China
  • Received:2017-08-27 Published:2018-06-25
  • Corresponding author: Chang Wang
  • About author:
    Corresponding author: Wang Chang, Email:
引用本文:

王畅. 微卫星状态对结肠癌术后辅助化疗决策的影响[J]. 中华结直肠疾病电子杂志, 2018, 07(03): 207-213.

Chang Wang. The impact of microsatellite status on decision-making of adjuvant chemotherapy in colon cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(03): 207-213.

结肠癌术后辅助化疗可延长患者生存、降低复发率及死亡率,如何筛选适合的患者进行治疗至关重要。当前,仅以疾病分期及临床病理高危因素来指导治疗已不能满足精准治疗的要求,联合应用肿瘤分子生物学相关指标才能更好的筛选患者、提高疗效。近年大量回顾性研究结果提示微卫星高度不稳定(MSI-H)或错配修复蛋白缺乏(dMMR)的结肠癌患者具有良好的预后,并且不能从单药氟尿嘧啶辅助化疗中获益,其可能是结肠癌术后辅助化疗决策制定的重要参考指标。本文对相关文献进行系统回顾与梳理,就微卫星状态对结肠癌预后、疗效预测以及辅助化疗决策的影响进行阐述。

It has been proved that adjuvant chemotherapy can improve overall survival, reduce the relapse rate and mortality in colon cancer. Screening out suitable patients to receive adjuvant chemotherapy is the key point. At present, the treatment strategy is almost based on the clinical stage and pathologic high risk factors and it cannot meet the requirements of precision therapy. Combined application of biomarker is helpful in screening patients and improving treatment efficacy. Recently multiple retrospective studies have shown that patients with microsatellite high instability or MMR-deficient CRCs have a more favorable prognosis, at the same time, do not benefit from treatment with adjuvant 5-fluorouracil chemotherapy. The microsatellite status maybe an important reference index and should be used to inform clinical decision-making for adjuvant chemotherapy. Through reviewing the literature, the impact of the microsatellite status on prognosis, predictive significance and decision-making of adjuvant chemotherapy in colon cancer has been expatiated in the paper.

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