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中华结直肠疾病电子杂志 ›› 2026, Vol. 15 ›› Issue (02) : 175 -180. doi: 10.3877/cma.j.issn.2095-3224.2026.02.009

综述

PROTAC在结直肠癌肿瘤微环境治疗中的研究进展
张逸辰1,2, 冯雨舟1,2, 鲍传庆1,2,()   
  1. 1 214122 无锡,江南大学附属医院胃肠外科
    2 214122,江南大学无锡医学院
  • 收稿日期:2025-08-19 出版日期:2026-04-25
  • 通信作者: 鲍传庆

Progress of PROTAC in colorectal cancer tumor microenvironment therapy

Yichen Zhang1,2, Yuzhou Feng1,2, Chuanqing Bao1,2,()   

  1. 1 Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214122, China
    2 Wuxi Medical College, Jiangnan University, Wuxi 214122, China
  • Received:2025-08-19 Published:2026-04-25
  • Corresponding author: Chuanqing Bao
引用本文:

张逸辰, 冯雨舟, 鲍传庆. PROTAC在结直肠癌肿瘤微环境治疗中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(02): 175-180.

Yichen Zhang, Yuzhou Feng, Chuanqing Bao. Progress of PROTAC in colorectal cancer tumor microenvironment therapy[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2026, 15(02): 175-180.

结直肠癌的治疗常受限于肿瘤微环境(TME)介导的免疫抑制与多重耐药。蛋白降解靶向嵌合体(PROTAC)技术通过募集E3泛素连接酶降解靶蛋白,在靶向“不可成药”分子方面展现出巨大潜力。本文系统综述了PROTAC在结直肠癌治疗中的研究进展,重点阐述了其与TME的相互作用机制。深入探讨了PROTAC如何通过降解致癌蛋白抑制肿瘤增殖并克服耐药,以及如何结合新型递送系统重塑免疫抑制性微环境、增强抗肿瘤免疫应答。结果表明,PROTAC技术凭借精准降解与微环境重塑的优势,为突破结直肠癌现有的治疗困境提供了新的方向。

The treatment of colorectal cancer is frequently constrained by tumour microenvironment (TME)-mediated immune suppression and multidrug resistance. Protein degradation-targeting chimeras (PROTACs) demonstrate significant potential in targeting “undruggable” molecules by recruiting E3 ubiquitin ligases to degrade target proteins. This paper provides a systematic review of PROTAC research progress in colorectal cancer therapy, with a particular emphasis on its interaction mechanisms with the TME. It explores in depth how PROTACs inhibit tumour proliferation and overcome resistance by degrading oncogenic proteins, and how they can be combined with novel delivery systems to remodel the immunosuppressive microenvironment and enhance anti-tumour immune responses. Results indicate that PROTAC technology, leveraging its precision degradation and microenvironment remodelling advantages, offers novel avenues for overcoming current therapeutic challenges in colorectal cancer.

图1 PROTAC作用机制与TME互作示意图。由BioRender.com创建
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