深在性囊性结肠炎（CCP）是一种临床上罕见的结直肠良性疾病。肉眼观为结直肠的囊性肿物，表面可有溃疡，病理学特点是囊肿深达黏膜下层、固有肌层甚至浆膜层，内含黏液，内壁被覆黏膜上皮细胞且无恶性肿瘤的证据。本病的重点在于与黏液腺癌相鉴别，因为误诊会导致过度的根治性治疗。本中心报道了1例发生于未成年患者的CCP伴部分腺上皮低级别上皮内瘤变的病例，并通过回顾相关的历史文献，对该疾病的发病机制及预后等问题进行了讨论。

Colitis cystica profunda (CCP) is a rare, benign disease of colorectum. To the naked eye, it is a cystic mass of the colorectum with ulceration on the surface. Pathologically, the cyst is filled with mucus and can grow down into the submucosa, lamina propria, and even serosa. The inner wall of the cyst is covered with mucosal epithelial cells and there is no evidence of malignancy. The focus of this disease is to differentiate it from mucinous adenocarcinoma because misdiagnosis can lead to excessive treatment. We reported a case of CCP with partial low-grade intraepithelial neoplasia of the glandular epithelium in a minor patient,and discussed the pathogenesis and prognosis of the disease by reviewing the relevant historical literature.