手术是目前结直肠癌肝转移患者获得生存延长的最佳治疗手段，临床实践中多数结直肠癌肝转移患者需要术前化疗，而化疗性肝损伤的严重程度及其对围术期安全性的影响亟须精确评估。吲哚菁绿（ICG）清除试验是肝储备功能定量检测的手段之一。对于肝硬化造成永久性的肝损伤，ICG试验可以精准地反映其肝储备功能的异常。但ICG试验能否反映化疗性肝损伤对肝储备功能的影响尚存在争议。本综述将从ICG试验反映肝储备功能的原理、应用及ICG指标异常与化疗性肝损伤有无和严重程度的相关性，以及与肝切除安全性的关系和ICG指标的影响因素等多个角度进行文献归纳总结，探讨ICG试验在化疗性肝损伤的评估中的作用。

Surgical resection of liver metastases is the best treatments for colorectal liver metastases, and can cure some patients or substantially prolong their survival. More patients received preoperative chemotherapy in practice, however the severity of chemotherapy associated liver injury and its effect on the safety of surgery was still in need of accurate evaluation. Indocyanine green (ICG) clearance test is one of the means of quantitative evaluation of hepatic reserve function, and successfully reflects abnormalities in hepatic reserve function in cirrhosis liver. However, whether ICG test can reflect the effects of chemotherapy induced liver injury on hepatic reserve function was still controversial. This article briefly reviews the principle and applications of ICG clearance and the correlation between ICG abnormalities and chemotherapeutic liver damage and its severity degrees. The usefulness of ICG test in the estimation of the postoperative risk of morbidity after liver resection and factors that may influence ICG index was also explored.