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中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (01) : 62 -66. doi: 10.3877/cma.j.issn.2095-3224.2018.01.013

所属专题: 文献

综述

雷替曲塞在晚期结直肠癌中的应用进展
吴振海1, 曲秀娟1,()   
  1. 1. 110001 辽宁省沈阳市中国医科大学附属第一医院肿瘤内科
  • 收稿日期:2017-05-22 出版日期:2018-02-25
  • 通信作者: 曲秀娟
  • 基金资助:
    辽宁省科学技术计划项目(No.2014226033); 辽宁省中央引导地方科技发展专项资金(No.2016007010)

An overview of raltitrexed in advanced colorectal cancer

Zhenhai Wu1, Xiujuan Qu1,()   

  1. 1. Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
  • Received:2017-05-22 Published:2018-02-25
  • Corresponding author: Xiujuan Qu
  • About author:
    Corresponding author: Qu Xiujuan, Email:
引用本文:

吴振海, 曲秀娟. 雷替曲塞在晚期结直肠癌中的应用进展[J]. 中华结直肠疾病电子杂志, 2018, 07(01): 62-66.

Zhenhai Wu, Xiujuan Qu. An overview of raltitrexed in advanced colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(01): 62-66.

以氟尿嘧啶为基础的化疗方案是结直肠癌患者的标准治疗方案,为患者带来很好的生存获益。但在耐药进展后,却往往面临无药可用的窘境。近年来,雷替曲塞的研发使用,在一定程度上缓和了这种矛盾。本文就目前雷替曲塞的作用机制及其在晚期结直肠癌临床应用中的现状做一综述。

Fluorouracil-based chemotherapy is the standard regimen for patients with colorectal cancer, and it makes admirable survival benefit. However, it would represent a formidable challenge of no other useful drug when they were resistant. Recently, the contradiction was alleviated to some extent by the application of raltitrexed. Here, we provide a brief review of the current researches about mechanism of raltitrexed and the clinical results of raltitrexed-based chemotherapy in advanced colorectal cancer.

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