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中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (01) : 67 -69. doi: 10.3877/cma.j.issn.2095-3224.2018.01.014

所属专题: 文献

综述

外泌体在肿瘤中的研究与进展
杨延巍1, 刘彦虹1,()   
  1. 1. 150086 哈尔滨医科大学附属第二医院检验科
  • 收稿日期:2017-06-15 出版日期:2018-02-25
  • 通信作者: 刘彦虹

Research and progression of exosome in tumor

Yanwei Yang1, Yanhong Liu1,()   

  1. 1. Department of Clinical Laboratory, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
  • Received:2017-06-15 Published:2018-02-25
  • Corresponding author: Yanhong Liu
  • About author:
    Corresponding author: Liu Yanhong, Email:
引用本文:

杨延巍, 刘彦虹. 外泌体在肿瘤中的研究与进展[J]. 中华结直肠疾病电子杂志, 2018, 07(01): 67-69.

Yanwei Yang, Yanhong Liu. Research and progression of exosome in tumor[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(01): 67-69.

近年来,越来越多的人开始对外泌体进行研究。外泌体具有传递信息,转录RNA的功能,其非编码区mRNAs是肿瘤等疾病发病机制的研究焦点。大量研究表明,肿瘤细胞可以释放大量外泌体,产生局部效应和全身反应。这篇文章中,我们针对外泌体最新研究进行总结,大致归纳为两点:(1)外泌体在肿瘤的生物学功能和机制有着重要作用;(2)外泌体可以作为肿瘤诊断的标志物,并可以监测病情变化。

The past decade has witnessed an exponential increase in research on exosomes. The capability of exosomes to transfer proteins, DNA, mRNA, as well as non-coding RNAs has made them an attractive focus of research into the pathogenesis of different diseases, including cancer. Increasing evidence suggests that tumor cells release a large sum of exosomes, which may not only influence in local microenvironment, but also can exert systemic effects. In this study, we review the current understanding on this topic, roughly divided into two broad facets of exosomes in cancer: (1) exosomes plays an important role in tumor biological function and mechanism; (2) exosomes can be used as a tumor diagnostic markers, and can monitor the condition changes.

[1]
Williams RL, Urbé S. The emerging shape of the ESCRT machinery [J]. Nat Rev Mol Cell Biol, 2007, 8(5): 355-368.
[2]
Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles [J]. Annu Rev Cell Dev Biol, 2014, 30(8): 255-289.
[3]
Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication [J]. Journal of proteomics, 2010, 73(10): 1907-1920.
[4]
Xin H, Li Y, Buller B, et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth [J]. Stem cells (Dayton, Ohio), 2012, 30(7): 1556-1564.
[5]
Wang S, Cesca F, Loers G, et al. Synapsin I is an oligomannosecarrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes [J]. The Journal of neuroscience: the officialjournal of the Society for Neuroscience, 2011, 31(20): 7275-7290.
[6]
Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles [J]. The Journal of experimental medicine, 1996, 183(3): 1161-1172.
[7]
Au Yeung CL, Co NN, Tsuruga T, et al. Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1 [J]. Nat Commun, 2016, 29(7): 11150.
[8]
Kogure T, Lin WL, Yan IK, et al. Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth [J]. Hepatology, 2011, 54(4): 1237-1248.
[9]
Roccaro AM, Sacco A, Maiso P, et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression [J]. Clin Invest, 2013, 123(4): 1542-1555.
[10]
Kosaka N, Iguchi H, Hagiwara K, et al. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis[J], Biol Chem, 2013, 288(15): 10849-10859.
[11]
Mincheva-Nilsson L, Baranov V. Cancer exosomes and NKG2D receptor-ligand interations: Impairing NKG2D mediated cytotoxicity and anti-tumor immune surveillance [J]. Semin Cancer Biol, 2014, 28: 24-30.
[12]
Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer [J]. Gynecol Oncol, 2008, 110(1): 13-21.
[13]
Zhu M, Huang Z, Zhu D, et al. A panel of microRNA signature in serum for colorectal cancer diagnosis [J]. Oncotarget, 2017, 8(10): 17081-17091.
[14]
Melo SA, Luecke LB, Kahlert C, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer [J]. Nature, 2015, 523(7559): 177-182.
[15]
Manier S, Liu CJ, Avet-Loiseau H, et al. Prognostic role of circulating exosomal miRNAs in multiple myeloma [J]. Blood, 2017, 129(17): 2429-2436.
[16]
Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma [J]. N Engl J Med, 2005, 352(10): 997-1003.
[17]
Alvarez-Erviti L, Seow Y, Yin H, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J]. Nat Biotechnol, 2011, 29(4): 341-345.
[18]
Tian Y, Li S, Song J, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy [J]. Biomaterials, 2014, 35(7): 2383-2390.
[19]
Kim MS, Haney MJ, Zhao Y, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells [J]. Nanomedicine, 2016, 12(3): 655-664.
[20]
Katakowski M, Buller B, Zheng X, et al. Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth [J]. Cancer Lett, 2013, 335(1): 201-204.
[21]
Ono M, Kosaka N, Tominaga N, et al. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells [J]. Sci Signal, 2014, 7(332): ra63.
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