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中华结直肠疾病电子杂志 ›› 2021, Vol. 10 ›› Issue (04) : 399 -403. doi: 10.3877/cma.j.issn.2095-3224.2021.04.011

综述

循环生物标志物在直肠癌新辅助放化疗疗效预测中的应用
周小妹1, 罗波1,(), 梁新军1   
  1. 1. 430079 武汉,华中科技大学同济医学院附属湖北肿瘤医院腹部放疗科;430079 武汉,湖北省结直肠癌临床医学研究中心;430079 武汉市结直肠癌临床医学研究中心
  • 收稿日期:2020-12-04 出版日期:2021-08-30
  • 通信作者: 罗波
  • 基金资助:
    湖北省自然科学基金面上项目(2017CFB555); 武汉市科技局应用基础研究计划(2020020601012250)

A review of the application of circulating biomarkers in prediction of efficacy of neoadjuvant chemoradiotherapy for rectal cancer

Xiaomei Zhou1, Bo Luo1,(), Xinjun Liang1   

  1. 1. Abdominal Radiotherapy Department, Hubei Cancer Hospital Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China; Hubei Colorectal Cancer Clinical Research Center, Wuhan 430079, China; Wuhan Colorectal Cancer Clinical Medical Research Center, Wuhan 430079, China
  • Received:2020-12-04 Published:2021-08-30
  • Corresponding author: Bo Luo
引用本文:

周小妹, 罗波, 梁新军. 循环生物标志物在直肠癌新辅助放化疗疗效预测中的应用[J/OL]. 中华结直肠疾病电子杂志, 2021, 10(04): 399-403.

Xiaomei Zhou, Bo Luo, Xinjun Liang. A review of the application of circulating biomarkers in prediction of efficacy of neoadjuvant chemoradiotherapy for rectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(04): 399-403.

局部进展期直肠癌(LARC)患者的标准治疗之一是使用新辅助放化疗。然而直肠癌只有大约15%~20%的患者在新辅助治疗后出现病理性完全缓解(pCR),而在大多数患者中观察到肿瘤部分消退,甚至部分患者不能从新辅助治疗中获益。因此,如何识别对新辅助放化疗(nCRT)治疗无效或者潜在完全缓解的患者对于局部进展期直肠癌个体化的诊疗是至关重要的。实际上越来越多的研究集中在发现和调查新的预测pCR反应的生物标志物上。循环生物标志物是指外周血中包括细胞、核酸、细胞外小泡、蛋白质和代谢物等物质,有足够的敏感性和特异性,与疾病的严重程度相关,可以观察到预后的或预测性的生物标记物效应。在这篇综述中,我们对于LARC患者中使用基于血液的潜在预测新辅助疗效的循环生物标志物的价值进行了综述。

Neoadjuvant chemoradiotherapy is one of the standard treatments for patients with locally advanced rectal cancer (LARC). However, only about 15%~20% of patients with rectal cancer experienced pathologic complete response (pCR) after neoadjuvant therapy, while partial tumor regression was observed in most patients, and even some patients could not benefit from neoadjuvant therapy. Therefore, how to identify patients with ineffective or potentially complete response to neoadjuvant chemoradiotherapy (nCRT) is crucial for the individualized diagnosis and treatment of locally advanced rectal cancer. An increasing number of studies have actually focused on the discovery and investigation of new biomarkers for predicting pCR reactions. Circulating biomarkers refer to substances in peripheral blood including cells, nucleic acids, extracellular vesicles, proteins and metabolites, etc., which have sufficient sensitivity and specificity and are related to the severity of the disease, and can observe prognostic or predictive biomarker effects. In this review, we review the value of blood-based circulating biomarkers that potentially predict neoadjuvant efficacy in LARC patients.

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