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中华结直肠疾病电子杂志 ›› 2020, Vol. 09 ›› Issue (06) : 581 -585. doi: 10.3877/cma.j.issn.2095-3224.2020.06.008

所属专题: 文献

论著

吻合口支架降低结肠术后吻合口漏发生率的动物研究
敬然1, 骆洋1, 秦骏1, 康红梅2, 黄轶洲1, 俞旻皓1, 钟鸣1,()   
  1. 1. 200127 上海交通大学医学院附属仁济医院胃肠外科
    2. 200240 上海交通大学材料科学与工程学院
  • 收稿日期:2020-03-15 出版日期:2020-12-25
  • 通信作者: 钟鸣
  • 基金资助:
    国家自然科学基金项目(No. 81802308;No. 81672347)

Anastomotic stent reduces the incidence of postoperative colonic anastomotic leakage: a study in rats

Ran Jing1, Yang Luo1, Jun Qin1, Hongmei Kang2, Yizhou Huang1, Minhao Yu1, Ming Zhong1,()   

  1. 1. Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
    2. School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2020-03-15 Published:2020-12-25
  • Corresponding author: Ming Zhong
  • About author:
    Corresponding author: Zhong Ming, Email:
引用本文:

敬然, 骆洋, 秦骏, 康红梅, 黄轶洲, 俞旻皓, 钟鸣. 吻合口支架降低结肠术后吻合口漏发生率的动物研究[J/OL]. 中华结直肠疾病电子杂志, 2020, 09(06): 581-585.

Ran Jing, Yang Luo, Jun Qin, Hongmei Kang, Yizhou Huang, Minhao Yu, Ming Zhong. Anastomotic stent reduces the incidence of postoperative colonic anastomotic leakage: a study in rats[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2020, 09(06): 581-585.

目的

通过比较放置吻合口支架与单纯手工缝合对大鼠结肠吻合口漏的影响,探索吻合口支架对降低结肠术后吻合口漏发生率的应用价值。

方法

以32只雄性SD大鼠为研究对象,随机分为2组,每组16只,行大鼠结肠端端吻合术,实验组行间断缝合的同时放置支架,即支架组;对照组单纯行间断缝合,即手工缝合组。比较两组腹腔粘连程度、吻合口漏、总生存率的差异。

结果

相对于手工缝合组,支架组吻合腹腔粘连程度评分较低(5.94±1.69 vs. 9.19±2.52,t=4.181;P=0.008);支架组吻合口漏发生率明显低于手工缝合组(12.5% vs. 56.25%,χ2=6.788;P=0.023);支架组总生存率高于手工缝合组(87.5% vs. 43.75%,χ2=5.850;P=0.016)。

结论

相对于手工缝合,吻合口支架可以减少大鼠术后腹腔粘连程度,降低吻合口漏发生率,具有潜在临床应用价值。

Objective

To explore the value of anastomotic stent in reducing postoperative colonic anastomotic leakage by a comparison of the effect of anastomotic stent and manual interrupted suture on anastomotic leakage morbidity after colon surgery in rats.

Methods

Thirty-two male SD rats were randomly divided into two groups, sixteen in each group (the experimental group: anastomosed by anastomotic stent; the control group: anastomosed by manual interrupted suture), then underwent end-to-end colonic anastomosis, comparing the differences in degree of abdominal adhesion, anastomotic leakage, and overall survival between two groups.

Results

Compared with control group, the score of abdominal adhesion in the experimental group was lower (5.94±1.69 vs. 9.19±2.52, t=4.181; P=0.008), the morbidity of anastomotic leakage in the experimental group was lower (12.5% vs. 56.25%, χ2=6.788; P=0.023), the overall survival rate of the experimental group was higher (87.5% vs. 43.75%, χ2=5.850; P=0.016).

Conclusion

Anastomotic stent has potential clinical applicability in decreasing the morbidity of anastomotic leakage through reducing abdominal adhesion.

图1 吻合口支架设计图及支架照片
图2 建立SD大鼠结肠端端吻合模型。2A:术前,2B:术中,2C:术后
表1 腹腔粘连程度评分[7]
图3 两组SD大鼠术后腹腔粘连程度评分。***P<0.001
图4 两组大鼠术后吻合口漏例数
图5 实验组与对照组大鼠术后生存率
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