直肠癌术后贝伐单抗相关迟发型吻合口漏一例

doi:10.3877/cma.j.issn.2095-3224.2019.01.015

中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (01) : 74 -75. doi: 10.3877/cma.j.issn.2095-3224.2019.01.015

所属专题：经典病例；经典病例；文献；

病例报道

直肠癌术后贝伐单抗相关迟发型吻合口漏一例

吴昊言¹, 方超¹, 周总光¹^,^†(

)

^1. 610041　成都，四川大学华西医院胃肠外科中心

收稿日期:2017-05-18 出版日期:2019-02-25
通信作者: 周总光

Delayed rectal anastomotic leakage associated with bevacizumab therapy: a case report

Haoyan Wu¹, Chao Fang¹, Zongguang Zhou¹^,^†()

^1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

Received:2017-05-18 Published:2019-02-25
Corresponding author: Zongguang Zhou
About author:
Corresponding author: Zhou Zongguang, Email: zhou767@163.com

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贝伐单抗为抗血管内皮生长因子单克隆抗体，常用于复发或转移性结直肠癌的临床一线治疗；治疗期间吻合口相关并发症偶有报道。本次报道的病例为四川大学华西医院胃肠外科中心1例直肠癌术后治疗期间贝伐单抗相关迟发型吻合口漏，并进行文献回顾。

关键词: 直肠肿瘤, 贝伐单抗, 迟发型吻合口漏

Bevacizumab is an anti vascular endothelial growth factor monoclonal antibody and commonly used in the clinical treatment of recurrent or metastatic colorectal cancer. Anastomotic complications are occasionally reported during the treatment. This report is a case of delayed type anastomotic leakage related to bevacizumab during the treatment of rectal cancer in the Gastrointestinal Surgery Center of West China Hospital of Sichuan University, and the literature was reviewed.

Key words: Rectal neoplasms, Bevacizumab, Delayed anastomotic leakage

图2 腹部CT左侧大腿及会阴区积气表现

[1]	Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy [J]. Oncology, 2005, 69(suppl 3): 25-33.
[2]	Adenis A, Vanseymortier L, Foissey D, et al. Bevacizumab and postponed suture leakages after surgery for ulcerative colitis and rectal cancer [J]. Gut, 2007, 56(5): 734.
[3]	Ley EJ, Vukasin P, Kaiser AM, et al. Delayed rectovaginal fistula: a potential complication of bevacizumab (Avastin) [J]. Dis Colon Rectum, 2007, 50(6): 930.
[4]	Ganapathi AM, Westmoreland T, Tyler D, et al. Bevacizumab-associated fistula formation in postoperative colorectal cancer patients [J]. J Am Coll Surg, 2012, 214(4): 582-588.
[5]	Bege T, Lelong B, Viret F, et al. Bevacizumab-related surgical site complication despite primary tumor resection in colorectal cancer patients [J]. Ann Surg Oncol, 2009, 16(4): 856-860.
[6]	Lim M, Akhtar S, Sasapu K, et al. Clinical and subclinical leaks after low colorectal anastomosis: A clinical and radiologic study [J]. Dis Colon Rectum, 2006,49(10): 1611-1619.
[7]	Tibbs MK. Wound healing following radiation therapy: A review [J]. Radiother Oncol,1997, 42(2): 99-106.
[8]	Bege T, Lelong B, Viret F, et al. Bevacizumab-related surgical site complication despite primary tumor resection in colorectal cancer patients [J]. Ann Surg Oncol, 2009, 16(4): 856-860.
[9]	Badgwell BD, Camp ER, Feig B, et al. Management of bevacizumab-associated bowel perforation: A case series and review of the literature [J]. Ann Oncol, 2007, 19(3): 577-582.
[10]	Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab [J]. J Surg Oncol, 2005,91(3): 173-180.

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Delayed rectal anastomotic leakage associated with bevacizumab therapy: a case report

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