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中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (06) : 518 -522. doi: 10.3877/cma.j.issn.2095-3224.2018.06.004

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青年专家论坛

维生素D与结直肠癌的发生、预防与干预
陈冬芍1, 张小田1,()   
  1. 1. 100142,北京大学肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科,恶性肿瘤发病机制及转化研究教育部重点实验室
  • 收稿日期:2017-11-21 出版日期:2018-12-25
  • 通信作者: 张小田
  • 基金资助:
    首都特色临床应用基金(No.Z161100000516064)

The role of vitamin D in the carcinogenesis, prevention and intervention of colorectal cancer

Dongshao Chen1, Xiaotian Zhang1,()   

  1. 1. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Received:2017-11-21 Published:2018-12-25
  • Corresponding author: Xiaotian Zhang
  • About author:
    Corresponding author: Zhang Xiaotian, Email:
引用本文:

陈冬芍, 张小田. 维生素D与结直肠癌的发生、预防与干预[J/OL]. 中华结直肠疾病电子杂志, 2018, 07(06): 518-522.

Dongshao Chen, Xiaotian Zhang. The role of vitamin D in the carcinogenesis, prevention and intervention of colorectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(06): 518-522.

结直肠癌是我国常见恶性肿瘤,其发病机制涉及多个方面。近年来的流行病学及临床前研究均支持,维生素D缺乏可能是导致结直肠癌的危险因素之一,补充维生素D可能降低结直肠癌的发生,甚至改善抗肿瘤治疗的疗效,近年在ASCO会议中也有前瞻性研究进行探讨。本文就维生素D和结直肠癌之间的发生和预防的相关性研究进行综述,探讨维生素D目前在结直肠癌预防和治疗中的作用。

Colorectal cancer is a common malignant tumor in China, and its pathogenesis involves many aspects. Recently, both epidemiology and preclinical studies support that vitamin D deficiency might be one of the risk factors for colorectal cancer, and vitamin D supplement might reduce the incidence of colorectal cancer and even improve the efficacy of anti-tumor therapy. The ASCO meeting also has discussed the prospective studies. This article reviews the correlation between vitamin D and colorectal cancer occurrence and prevention, and discusses the role of vitamin D in the prevention and treatment of colorectal cancer.

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