切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2018, Vol. 07 ›› Issue (06) : 514 -517. doi: 10.3877/cma.j.issn.2095-3224.2018.06.003

所属专题: 文献

专家论坛

左、右半结肠癌的差异
胡继霖1, 卢云1,()   
  1. 1. 266000 青岛大学附属医院黄岛院区胃肠外科
  • 收稿日期:2017-11-27 出版日期:2018-12-25
  • 通信作者: 卢云

The differences between the left-side and the right-sided colon cancer

Jilin Hu1, Yun Lu1,()   

  1. 1. Department of GI Surgery, Huangdao Branch, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2017-11-27 Published:2018-12-25
  • Corresponding author: Yun Lu
  • About author:
    Corresponding author: Lu Yun, Email:
引用本文:

胡继霖, 卢云. 左、右半结肠癌的差异[J/OL]. 中华结直肠疾病电子杂志, 2018, 07(06): 514-517.

Jilin Hu, Yun Lu. The differences between the left-side and the right-sided colon cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(06): 514-517.

目前认为左、右半结肠癌是两种不同的疾病,二者在临床特征、流行病学、组织学、分子生物学、靶向药物治疗、预后等方面存在明显差异,因此二者的治疗理念也不尽相同。对于左、右半结肠癌差异的深入认识,可以指导临床医生在精准医疗时代对患者做出准确的个体化评价和精准化治疗。

Recent researches discovered that the left and right colon cancer are two different diseases, which differ significantly in clinical features, epidemiology, histology, molecular biology, targeted drug treatment and prognosis. So the treatments for the left and right colon cancer are different. Further understanding of the differences between the left and right colon cancers can guide clinicians to make accurate individual evaluations and precise treatments for patients in the era of accurate medical treatment.

[1]
Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014 [J]. CA Cancer J Clin, 2014, 64(1): 9-29.
[2]
Chen WQ, Zhang SR, Zhang SW, et al. Report of cancer incidence and mortality in China, 2012 [J]. China Cancer, 2016, 25(1): 1-8.
[3]
Benedix F, Kube R, Meyer F, et al. Comparison of 17, 641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival [J]. Dis Colon Rectum, 2010, 53(1): 57-64.
[4]
Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location [J]. Ann Intern Med, 1990, 113(10): 779-788.
[5]
Cheng L, Eng C, Nieman LZ, et al. Trends in colo-rectal cancer incidence by anatomic site and disease stage in the United States from 1976 to 2005 [J]. Am J Clin Oncol, 2011, 34(6): 573-580.
[6]
Boise MK, Johansen JS, Dehlendorff C, et al. Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer [J]. Annals of Oncology, 2013, 24(10): 2554-2559.
[7]
Carethers JM. One colon lumen but two organs [J]. Gastroenterology, 2011, 141(2): 411-442.
[8]
Wu X, Chen VW, Martin J, et al. Sub-site-specific colorectal cancer incidence rates and stage distributions among Asians an d Pacific Islanders in the United States, 1995 to 1999 [J]. Cancer Epidemioly Biomarkers Prev, 2004, 13(7): 1215-1222.
[9]
Chin CC, Wang JY, Yeh CY, et al. Metastatic lymph node ratio is a more precise predictor of prognosis than number of lymph node metastases Ⅲ colon cancer [J]. Int J Colorectal Dis, 2009, 24(11): 1297-1302.
[10]
Albuquerque C, Bakker ER, van Veelen W, et al. Colorectal cancers choosing sides [J]. Biochim Biophys Acta, 2011, 1816(2): 219-231.
[11]
Rebecca LS, Elizabeth MW, Ahmedin J. Trends in Colorectal Cancer Incidence Rates in the United States by Tumor Location and Stage, 1992–2008 [J]. American Association for Cancer Research, 2012, 21(3): 411-416.
[12]
Price TJ, Beeke C, Ullah S, et al. Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease [J]. Cancer, 2015, 121(6): 830-835.
[13]
Weiss JM, Pfau PR, OʹConnor ES, et al. Mortality by stage for right-versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results-Medicare data [J]. J Clin Oncol: official journal of the American Society of Clinical Oncology, 2011, 29(33): 4401-4409.
[14]
Meguid RA, Slidell MB, Wolfgang CL, et al. Is there a difference in survival between right-versus left-sided colon cancers? [J]. Ann Surg Oncol, 2008, 15(9): 2388-2394.
[15]
Snaebjornsson P, Coupe VM, Jonasson L, et al. Colon cancer in Iceland--a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age [J]. Int J Cancer, 2010, 127(11): 2645-2653.
[16]
Worthley DL, Leggett BA. Colorectal cancer: molecular features and clinical opportunities [J]. Clin Biochem Rev, 2010, 31(2): 31-38.
[17]
Nosho K, Irahara N, Shima K, et al. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample [J]. PloS One, 2008, 3(11): e3698.
[18]
Roth AD, Delorenzi M, Tejpar S, et al. Integrated analysis of molecular and clinical prognostic factors in stageⅡ/Ⅲ colon cancer [J]. J Natl Cancer Inst, 2012, 104(21): 1635-1646.
[19]
Bae JM, Kim JH, Cho NY, et al. Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumor location [J]. Br J Cancer, 2013, 109(4): 1004-1012.
[20]
Barault L, Charon-Barra C, Jooste V, et al. Hypermethylatorpheno type in sporadic colon cancer: study on a population-based series of 582 cases [J]. Cancer Res, 2008, 68(20): 8541-8546.
[21]
Weisenberger DJ, Siegmund KD, Campan M, et al. CpG islandmethylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer [J]. Nat Genet, 2006, 38(7): 787-793.
[22]
Russo A, Bazan V, Iacopetta B, et al. The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment [J]. J Clin Oncol, 2005, 23(30): 7518-7528.
[23]
Brule SY, Jonker DJ, Karapetis CS, et al. Location of colon cancer (right-sided versus left-sided) as a pregnostic factor and a predictor of benefit from cetuximab in NCIC CO.17 [J]. Eur J Cancer, 2015, 51(11): 1405-1414.
[24]
von Einem JC, Heinemann V, von Weikersthal LF, et al. Left-sided primary tumors are associated with favorable prognosis in patients with KRAS cod on 1213 wild-type metastatic colorectal cancer treated with cetuximab plus chemotherapy: an analysis of the AIO KRK-0104 trial [J]. J Cancer Res Clin Oncol, 2014, 140(9): 1607-1614.
[25]
Moritani K, Hasegawa H, Okabayashi K, et al. Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution [J]. Surg Today, 2014, 44(9): 1685-1691.
[26]
Gao P, Song YX, Xu YY, et al. Does the prognosis of colorectal mucinous carcinoma depend upon the primary tumor site? Results from two independent databases [J]. Histopathology, 2013, 63(5): 603-615.
[1] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[2] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[3] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[4] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[5] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[6] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[7] 顾雯, 凌守鑫, 唐海利, 甘雪梅. 两种不同手术入路在甲状腺乳头状癌患者开放性根治性术中的应用比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 687-690.
[8] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[9] 陈樽, 王平, 金华, 周美玲, 李青青, 黄永刚. 肌肉减少症预测结直肠癌术后切口疝发生的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 639-644.
[10] 刘郁, 段绍斌, 丁志翔, 史志涛. miR-34a-5p 在结肠癌患者的表达及其与临床特征及预后的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 485-490.
[11] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
[12] 曾明芬, 王艳. 急性胰腺炎合并脂肪肝患者CT 与彩色多普勒超声诊断参数与其病情和预后的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 531-535.
[13] 沈炎, 张俊峰, 唐春芳. 预后营养指数结合血清降钙素原、胱抑素C及视黄醇结合蛋白对急性胰腺炎并发急性肾损伤的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 536-540.
[14] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[15] 郭曌蓉, 王歆光, 刘毅强, 何英剑, 王立泽, 杨飏, 汪星, 曹威, 谷重山, 范铁, 李金锋, 范照青. 不同亚型乳腺叶状肿瘤的临床病理特征及预后危险因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 524-532.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?