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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (04) : 292 -296. doi: 10.3877/cma.j.issn.2095-3224.2016.04.003

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精准医疗时代低位直肠癌选择性侧方淋巴结清扫价值与策略
王海江1,(), 葛磊1   
  1. 1. 830011 新疆医科大学附属肿瘤医院胃肠外科
  • 收稿日期:2016-03-21 出版日期:2016-08-25
  • 通信作者: 王海江
  • 基金资助:
    国家自然科学基金资助项目(No.81560385)

Strategies and value of the treatment of lateral lymphnode dissection for low rectal cancer in the era of precision medicine

Haijiang Wang1,(), Lei Ge1   

  1. 1. Department of Gastrointestinal Surgery, Xinjiang Medical University Affiliated Tumor Hospital. Xinjiang 830011, China
  • Received:2016-03-21 Published:2016-08-25
  • Corresponding author: Haijiang Wang
  • About author:
    Corresponding author: Wang Haijiang, Email:
引用本文:

王海江, 葛磊. 精准医疗时代低位直肠癌选择性侧方淋巴结清扫价值与策略[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(04): 292-296.

Haijiang Wang, Lei Ge. Strategies and value of the treatment of lateral lymphnode dissection for low rectal cancer in the era of precision medicine[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(04): 292-296.

随着生物分析技术、基因测序以及大数据分析工具的出现,医学进入了精准医疗时代。临床影像等技术的进步和发展,肿瘤患者术前精准临床分期判断及分子生物学信息的获得使得个体化的精准医疗成为可能,精准医疗时代对直肠癌的诊治提出了新的要求,不同部位的直肠癌治疗方案亦有所差异。手术治疗仍然是当今治疗直肠癌的主要方式,对于侧方淋巴结清扫问题一直存有争议,究其原因侧方淋巴结转移(lateral pelvic lymph node metastasis,LPLM)是全身系统性转移还是局部转移。笔者认为,低位直肠癌诊治应在充分推广诊疗规范的基础上,通过对数据的分析,筛选行侧方淋巴结手术治疗的获益人群,根据精确的诊断分期控制手术指征与范围,减少不必要的创伤及过度治疗从而真正实现精准医疗。

With the emergency of biological technology, gene sequencing and big data analysis tools, medical treatment entered the era of precision medical. As a result of the progress and development of clinical imaging techniques, the acquisition of clinical and personal biological data has made personalized treatment possible. The era of precision medicine has brought new horizon for diagnosis and treatment of rectal cancer. Different treatment should be taken into account in a different location in rectal cancer. Surgery is still considered as the principal treatment for rectal cancer, however, there is long-standing controversy as to whether LPN metastases represent systemic or localized disease. Based on the promotion of standard treatment for rectal cancer, we must share following views that the different subjects should join forces to improve selection criteria for LPND, avoid unnecessary injury, prevent over treatment, and ultimately aim to propose the precision medicine program in the future for patients with low rectal cancer.

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