探讨GI-pill胃肠电子胶囊在慢传输型便秘中的应用价值。

将81例排除出口梗阻型便秘和肠道器质性疾病，同意接受胃肠电子胶囊检测的慢性便秘患者，数字随机法分为两组，研究组42例，同时口服胃肠电子胶囊和不透X线颗粒胶囊；对照组39例单独口服不透X线颗粒胶囊；口服后2组患者均填写饮食、活动、休息等临床记录表，每隔24小时拍摄腹部X线立卧位平片，直至腹腔残留不透X线颗粒数小于4粒，研究组同时连续观察体外数据记录仪运行状态直至电子胶囊排出体外回收；对照分析2组结肠运输试验结果，统计分析GI-pill胃肠电子胶囊在体时间、胃、小肠、结肠通过时间，HAPCs数量、生理响应比。

研究组和对照组结肠运输试验平均时间分别为4.94±1.31天和4.85±1.35天，右半结肠通过时间、左半结肠通过时间及直乙结肠通过时间分别是1.38±0.62天和1.35±0.53天，1.97±0.99天和2.02±0.90天，1.52±0.74天和1.58±0.71天，相比无统计学差异；研究组GI-pill胃肠电子胶囊在体时间与结肠运输试验时间分别为120.0±15.32小时和4.9±1.32天，胃肠电子胶囊在胃、小肠和结直肠的时间分别为5.83±3.12小时、8.75±4.01小时、94.7±17.63小时，HAPCs总数、群发HAPCs和生理响应比分别为14.2±5.14个、4.9±2.26个和39.20%。全体患者研究期间无腹痛、呕吐、黑便等不适表现。

GI-pill胃肠电子胶囊可连续评价慢传输便秘患者消化道动力特征，与结肠运输试验有很好的同一性，值得临床推广应用。

To explore the application of GI-pill gastrointestinal electronic capsule in slow transit constipation.

81 patients with slow transit constipation, who had been ruled out outlet obstructive constipation and organic intestinal disease and agreed to move forward with the test of GI-pill gastrointestinal electronic capsule, were assigned randomly into two groups.42 cases of study group were given gastrointestinal electronic capsule and X-ray opaque granules capsule, while 39 cases of control group were given X-ray opaque granules capsule alone.The clinical records including diet, activation and rest would be accomplished after oral administration.The abdominal X-ray would be carried out every 24 hours until the number of residual X-ray opaque granules was less than 4.In the meantime the operating state of data recorder in vitro would be observed continuously until the electronic capsule was excreted and recycled.The results of colonic transit test in two groups would be used by case-control analysis.The records of GI-pill gastrointestinal electronic capsule including transit time in vivo, stomach, small intestine and colon, the number of HAPCs and the ratio of physiological response would be analyzed.

In study group and control group respectively, the average time of colonic transit test was 4.94±1.31 days and 4.85±1.35 days.The transit time of right colon, left colon and rectosigmoid was1.38±0.62days and 1.35±0.53days, 1.97±0.99 days and 2.02±0.90days, 1.52±0.74 days and 1.58±0.71days respectively, which showed no significant difference.In study group the transit time of GI-pill gastrointestinal electronic capsule in vivo was 5.0±0.64 days and colonic transit time was 4.9±1.32 days.The transit time of gastrointestinal electronic capsule of stomach, small intestine and colorectum was 5.83±3.12hours and 8.75±4.01 hours, 94.7±17.63 hours, respectively.During the study period, there were no discomfort performances of abdominal pain, vomiting and tarry stool in patients.

GI-pill gastrointestinal electronic capsule in good agreement with colonic transit test could be applied to assess continuously the dynamic characteristics of digestive tract in patients with slow transit constipation.It is worth popularizing application in clinic.