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中华结直肠疾病电子杂志 ›› 2015, Vol. 04 ›› Issue (01) : 45 -49. doi: 10.3877/cma.j.issn.2095-3224.2015.01.10

所属专题: 文献

论著

Stathmin及Cathepsin B在结直肠癌中的表达
杨正多1, 张丹1, 吕宏程1, 张丽1, 刘光1, 马卉1, 王刚1, 张诗武1,()   
  1. 1. 300121 天津,南开大学人民医院病理科
  • 收稿日期:2014-11-07 出版日期:2015-02-25
  • 通信作者: 张诗武

Expression of stathmin and cathepsin B in colorectal cancer

Zheng-duo YANG1, Dan ZHANG1, Hong-cheng LV1, Li ZHANG1, Guang LIU1, Hui MA1, Gang WANG1, Shi-wu ZHANG1,()   

  1. 1. Department of Pathology, Nankai University Affiliated Hospital, Tianjin 300121, China
  • Received:2014-11-07 Published:2015-02-25
  • Corresponding author: Shi-wu ZHANG
  • About author:
    Corresponding author: ZHANG Shi-wu, Email:
引用本文:

杨正多, 张丹, 吕宏程, 张丽, 刘光, 马卉, 王刚, 张诗武. Stathmin及Cathepsin B在结直肠癌中的表达[J]. 中华结直肠疾病电子杂志, 2015, 04(01): 45-49.

Zheng-duo YANG, Dan ZHANG, Hong-cheng LV, Li ZHANG, Guang LIU, Hui MA, Gang WANG, Shi-wu ZHANG. Expression of stathmin and cathepsin B in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(01): 45-49.

目的

研究Stathmin和Cathepsin B在人结直肠癌组织及其转移灶中的表达差异,探讨Stathmin和Cathepsin B在结直肠癌发生发展过程中的作用及其临床病理意义。

方法

用免疫组织化学染色技术检测158例高分化,中分化及低分化结直肠癌患者手术切除标本及64例相应转移灶组织中Stathmin蛋白和Cathepsin B蛋白的表达情况。

结果

Stathmin蛋白及Cathepsin B蛋白在结直肠癌组织及其转移灶中均高表达(分别为P<0.05及P<0.01);高分化结直肠癌样本中Stathmin蛋白及Cathepsin B蛋白在细胞膜或细胞浆阳性表达,而在低分化结直肠癌细胞核,细胞膜及细胞浆中可见二者的阳性表达。

结论

Stathmin及Cathepsin B可能是判断结直肠癌患者临床病理分级的有用指标。

Objective

To investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci and its clinicopathological significance.

Methods

Immunohistochemical staining for Stathmin and Cathepsin B was performed in 158 cases of colorectal cancer tissues and related 64 cases of metastatic foci within the tissue microarray.

Results

Both Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples(P<0.05 and P<0.01 respectively). The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high to mediate differentiation samples.

Conclusion

Stathmin and Cathepsin B may be valuable biomarkers for clinical differentiation of colorectal cancer.

图1 Stathmin蛋白及Cathpsin B蛋白在结直肠癌组织及转移灶组织中的表达情况免疫组织化学染色图像(×200)
图2 Stathmmin蛋白在结直肠癌组织及转移灶组织中的表达百分比柱形图
图3 Cathepsin B蛋白在结直肠癌组织及转移灶组织中的表达半分比柱形图
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