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中华结直肠疾病电子杂志 ›› 2025, Vol. 14 ›› Issue (02) : 142 -147. doi: 10.3877/cma.j.issn.2095-3224.2025.02.005

青年专家论坛

肠道菌群失衡与功能性肠病:从机制探讨到肠菌移植疗法
朱万涌1,2,3, 王乐2,3, 徐越2,3, 王新军2,3, 叶晨2,3, 李宁2,3, 陈启仪2,3, 李龙2,3,()   
  1. 1. 232001 淮南,安徽理工大学第一临床医学院
    2. 200000 上海,同济大学附属第十人民医院普通外科功能肠道外科
    3. 200000 上海市肠道微生态研究中心
  • 收稿日期:2024-11-07 出版日期:2025-04-25
  • 通信作者: 李龙
  • 基金资助:
    上海市卫生健康委员会临床研究项目(No. 20234Y0079)同济大学附属第十人民医院研究型医师项目(No.YJXYS-C-003)

Gut microbiota dysbiosis and functional intestinal disorders:from mechanistic insights to fecal microbiota transplantation therapy

Wanyong Zhu1,2,3, Le Wang2,3, Yue Xu2,3, Xinjun Wang2,3, Chen Ye2,3, Ning Li2,3, Qiyi Chen2,3, Long Li2,3,()   

  1. 1. Anhui University of Science and Technology First Clinical Medical College,Huainan 232001,China
    2. Department of Functional Intestinal Diseases,General Surgery of Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200000,China
    3. Shanghai Gastrointestinal Microecology Research Center,Shanghai 200000,China
  • Received:2024-11-07 Published:2025-04-25
  • Corresponding author: Long Li
引用本文:

朱万涌, 王乐, 徐越, 王新军, 叶晨, 李宁, 陈启仪, 李龙. 肠道菌群失衡与功能性肠病:从机制探讨到肠菌移植疗法[J/OL]. 中华结直肠疾病电子杂志, 2025, 14(02): 142-147.

Wanyong Zhu, Le Wang, Yue Xu, Xinjun Wang, Chen Ye, Ning Li, Qiyi Chen, Long Li. Gut microbiota dysbiosis and functional intestinal disorders:from mechanistic insights to fecal microbiota transplantation therapy[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(02): 142-147.

功能性肠病(FIDs)是一类常见的慢性胃肠疾病,其发病机制复杂,涉及肠-脑轴、免疫系统、肠道菌群等多种因素。近年来的研究表明,肠道菌群失衡在FIDs的发生和症状加重中扮演了重要角色,尤其是在肠易激综合征(IBS)、功能性腹泻和便秘等亚型中。肠菌移植(FMT)作为一种调节肠道菌群的治疗手段,逐渐受到关注,并在部分临床试验中显示出显著疗效。然而,FMT的应用在疗效持久性、安全性及个体差异性方面仍存在挑战。此外,益生菌、益生元等辅助治疗手段也被认为可在改善症状方面发挥协同作用。未来研究将进一步探索FMT与益生菌联合应用的可能性,并优化治疗方案,以实现功能性肠病的个性化和精准化管理。

Functional intestinal disorders(FIDs) are common chronic gastrointestinal diseases with complex mechanisms involving the gut-brain axis,immune system,and gut microbiota. Recent studies indicate that gut microbiota imbalance plays a crucial role in the onset and exacerbation of FIDs,especially in subtypes such as irritable bowel syndrome (IBS),functional diarrhea,and constipation. Fecal microbiota transplantation(FMT),as a method to modulate gut microbiota,has gained increasing attention and shown significant efficacy in some clinical trials. However,challenges remain in the application of FMT,particularly regarding efficacy sustainability,safety,and individual variability. Additionally,adjunctive treatments,such as probiotics and prebiotics,are also believed to have synergistic effects in symptom improvement. Future research will explore the potential for combined application of FMT with probiotics and optimize therapeutic strategies to achieve personalized and precise management of FIDs.

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