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中华结直肠疾病电子杂志 ›› 2025, Vol. 14 ›› Issue (02) : 136 -141. doi: 10.3877/cma.j.issn.2095-3224.2025.02.004

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肠道菌群移植对菌-肠-脑轴疾病的治疗研究进展
陈俊夫1,2, 吴纪霞1, 田宏亮1,2, 马静1,()   
  1. 1. 233000 蚌埠市第一人民医院神经内科
    2. 200072 上海,同济大学医学院
  • 收稿日期:2024-11-08 出版日期:2025-04-25
  • 通信作者: 马静
  • 基金资助:
    安徽省临床医学研究转化专项(No. 202304295107020025)同济大学附属第十人民医院攀登人才计划项目(No. 2021SYPDRC045)蚌埠市卫生健康委科研项目(No. BBWK2023A105)

FMT in microbiota-gut-brain axis disorders:therapeutic advances

Junfu Chen1,2, Jixia Wu1, Hongliang Tian1,2, Jing Ma1,()   

  1. 1. Department of Neurology,Bengbu First People's Hospital,Bengbu 233000,China
    2. Tongji University School of Medicine,Shanghai 200072,China
  • Received:2024-11-08 Published:2025-04-25
  • Corresponding author: Jing Ma
引用本文:

陈俊夫, 吴纪霞, 田宏亮, 马静. 肠道菌群移植对菌-肠-脑轴疾病的治疗研究进展[J/OL]. 中华结直肠疾病电子杂志, 2025, 14(02): 136-141.

Junfu Chen, Jixia Wu, Hongliang Tian, Jing Ma. FMT in microbiota-gut-brain axis disorders:therapeutic advances[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(02): 136-141.

肠道被称为是人类的“第二大脑”,肠道和大脑功能之间互为因果恶性循环,肠道疾病和中枢神经退行性病变、精神心理疾病常同时伴随。其最重要的中间媒介是肠道菌群。肠道菌群的异常,不仅可以直接导致肠道功能障碍,同时可以通过免疫调控和神经递质的合成与释放影响中枢神经系统的功能,而肠道和中枢神经系统的异常也可以进一步导致肠道菌群的紊乱。作为人为调控肠道菌群的手段,肠道菌群移植(FMT)在治疗菌-肠-脑轴相关疾病方面正受到越来越多的关注。

The intestine is known as the “second brain” of humans. There is a vicious cycle of mutual causality between intestinal and brain functions,and intestinal diseases are often accompanied by central nervous system degenerative diseases and mental and psychological disorders. The most important intermediate mediator is the intestinal flora. Abnormalities in the intestinal flora can not only directly lead to intestinal dysfunction,but also affect the function of the central nervous system through immune regulation and the synthesis and release of neurotransmitters. Abnormalities in the intestine and central nervous system can further lead to disorders in the intestinal flora. As a means of artificial regulation of the gut microbiota,fecal microbiota transplantation(FMT) is garnering increasing attention in the treatment of diseases related to the microbiota-gut-brain axis.

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