切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 107 -111. doi: 10.3877/cma.j.issn.2095-3224.2023.02.003

腹膜疾病专栏

结直肠癌腹膜转移免疫治疗的研究现状与进展
方洪生1, 顾睿祈1, 蔡国响1,()   
  1. 1. 200032 上海,复旦大学附属肿瘤医院大肠外一科,复旦大学上海医学院肿瘤学系
  • 收稿日期:2022-05-10 出版日期:2023-04-25
  • 通信作者: 蔡国响
  • 基金资助:
    上海市卫生健康委员会卫生健康学科带头人计划(2022XD012); 上海申康医院发展中心医企融合创新成果转化专项(SHDC2022CRD046); 上海市“医苑新星”杰出青年医学人才培养资助计划(SHWSRS(2021)_099)

Current status and progress of immunotherapy for peritoneal metastatic colorectal cancer

Hongsheng Fang1, Ruiqi Gu1, Guoxiang Cai1,()   

  1. 1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Received:2022-05-10 Published:2023-04-25
  • Corresponding author: Guoxiang Cai
引用本文:

方洪生, 顾睿祈, 蔡国响. 结直肠癌腹膜转移免疫治疗的研究现状与进展[J]. 中华结直肠疾病电子杂志, 2023, 12(02): 107-111.

Hongsheng Fang, Ruiqi Gu, Guoxiang Cai. Current status and progress of immunotherapy for peritoneal metastatic colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(02): 107-111.

我国结直肠癌(CRC)发病率居恶性肿瘤第二位,死亡率居第四位,手术及放化疗能明显改善肠癌患者的预后,但发生腹膜转移往往提示预后不良。近年来,随着基础医学的突破以及临床药物转化的加速,免疫治疗应用于腹膜转移癌也取得重大突破,成为一种重要的治疗方式。本文总结了近年来国内外腹膜转移癌免疫治疗的研究进展,并进行综述。

Colorectal cancer (CRC) remains the second highest incidence and the fourth highest mortality rate among malignant tumors in China. Surgery, radiotherapy and chemotherapy significantly improve the prognosis of CRC patients, but the prognosis will be poor when peritoneal metastasis occurs. In recent years, with the breakthrough of basic medicine and the acceleration of clinical drug transformation, immunotherapy has become increasingly important and showed great potential in the treatment of peritoneal metastatic CRC. This article summarized the immunotherapy of peritoneal metastatic CRC at home and abroad in recent years.

[1]
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2]
Riihimäki M, Hemminki A, Sundquist J, et al. Patterns of metastasis in colon and rectal cancer [J]. Sci Rep, 2016, 6: 29765.
[3]
Franko J, Shi Q, Goldman CD, et al. Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase Ⅲ trials N9741 and N9841[J]. J Clin Oncol, 2012, 30(3): 263-267.
[4]
Sánchez-hidalgo JM, Rodríguez-ortiz L, Arjona-sánchez Á, et al. Colorectal peritoneal metastases: Optimal management review[J]. World J Gastroenterol, 2019, 25(27): 3484-3502.
[5]
Yurttas C, Hoffmann G, Tolios A, et al. Systematic review of variations in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis from colorectal cancer[J]. J Clin Med, 2018, 7(12): 567.
[6]
Capobianco A, Cottone L, Monno A, et al. The peritoneum: healing, immunity, and diseases[J]. J Pathol, 2017, 243(2): 137-147.
[7]
Cortés-guiral D, Hübner M, Alyami M, et al. Primary and metastatic peritoneal surface malignancies[J]. Nat Rev Dis Primers, 2021, 7(1): 91.
[8]
Kojima M, Higuchi Y, Yokota M, et al. Human subperitoneal fibroblast and cancer cell interaction creates microenvironment that enhances tumor progression and metastasis[J]. PLoS One, 2014, 9(2): e88018.
[9]
MikuŁa-pietrasik J, Uruski P, Tykarski A, et al. The peritoneal "soil" for a cancerous "seed": a comprehensive review of the pathogenesis of intraperitoneal cancer metastases[J]. Cell Mol Life Sci, 2018, 75(3): 509-525.
[10]
Sun X, Suo J, Yan J. Immunotherapy in human colorectal cancer: Challenges and prospective[J]. World J Gastroenterol, 2016, 22(28): 6362-6372.
[11]
Biller LH, Schrag D. Diagnosis and treatment of metastatic colorectal cancer: a review[J]. JAMA, 2021, 325(7): 669-685.
[12]
中国医师协会结直肠肿瘤专业委员会腹膜肿瘤专委会. 结直肠癌腹膜转移诊治中国专家共识(2022版)[J/OL]. 中华结直肠疾病电子杂志, 2022, 11(4): 265-271.
[13]
Ganesh K, Stadler Z K, Cercek A, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential [J]. Nat Rev Gastroenterol Hepatol, 2019, 16(6): 361-375.
[14]
Le DT, Kim TW, Van Cutsem E, et al. Phase II Open-label study of pembrolizumab in treatment-refractory, microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: KEYNOTE-164 [J]. J Clin Oncol, 2020, 38(1): 11-19.
[15]
Overman MJ, Mcdermott R, Leach JL, et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study [J]. Lancet Oncol, 2017, 18(9): 1182-1191.
[16]
André T, Shiu KK, Kim TW, et al. Pembrolizumab in microsatellite-instability-high advanced colorectal cancer[J]. N Engl J Med, 2020, 383(23): 2207-2218.
[17]
Network NCC. (NCCN) Clinical Practice Guidelines in Oncology. Colon Cancer, Version 2. 2022. [J]. NCCN, 2022.
[18]
Berek JS, Knapp RC, Hacker NF, et al. Intraperitoneal immunotherapy of epithelial ovarian carcinoma with Corynebacterium parvum[J]. Am J Obstet Gynecol, 1985, 152(8): 1003-1010.
[19]
Berek JS. Intraperitoneal adoptive immunotherapy for peritoneal cancer[J]. J Clin Oncol, 1990, 8(10): 1610-1612.
[20]
Steis RG, Urba WJ, Vandermolen LA, et al. Intraperitoneal lymphokine-activated killer-cell and interleukin-2 therapy for malignancies limited to the peritoneal cavity [J]. J Clin Oncol, 1990, 8(10): 1618-1629.
[21]
Nash AM, Jarvis MI, Aghlara-fotovat S, et al. Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors [J]. Sci Adv, 2022, 8(9): eabm1032.
[22]
Miller AM, Lemke-miltner CD, Blackwell S, et al. Intraperitoneal CMP-001: A novel immunotherapy for treating peritoneal carcinomatosis of gastrointestinal and pancreaticobiliary cancer [J]. Ann Surg Oncol, 2021, 28(2): 1187-1197.
[23]
Jiang T, Zhang H, Li Y, et al. Intraperitoneal injection of class A TLR9 agonist enhances anti-PD-1 immunotherapy in colorectal peritoneal metastases [J]. JCI Insight, 2022, 7(20): e160063.
[24]
Lee SJ, Yang H, Kim WR, et al. STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer[J]. J Immunother Cancer, 2021, 9(6): e002195.
[25]
Zhao Z, Zheng L, Chen W, et al. Delivery strategies of cancer immunotherapy: recent advances and future perspectives [J]. J Hematol Oncol, 2019, 12(1): 126.
[26]
Saxena M, Van Der Burg SH, Melief CJM, et al. Therapeutic cancer vaccines[J]. Nat Rev Cancer, 2021, 21(6): 360-378.
[27]
Harrington K, Freeman DJ, Kelly B, et al. Optimizing oncolytic virotherapy in cancer treatment [J]. Nat Rev Drug Discov, 2019, 18(9): 689-706.
[28]
Alkayyal AA, Tai LH, Kennedy MA, et al. NK-cell recruitment is necessary for eradication of peritoneal carcinomatosis with an Il12-expressing maraba virus cellular vaccine[J]. Cancer Immunol Res, 2017, 5(3): 211-221.
[29]
Lee YS, Lee WS, Kim CW, et al. Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer[J]. J Immunother Cancer, 2020, 8(2): e000857.
[30]
Lauer UM, Schell M, Beil J, et al. Phase I study of oncolytic vaccinia virus GL-ONC1 in patients with peritoneal carcinomatosis[J]. Clin Cancer Res, 2018, 24(18): 4388-4398.
[31]
Zamarin D, Odunsi K, Zsiros E, et al. Study to evaluate intraperitoneal (IP) ONCOS-102 with systemic durvalumab in patients with peritoneal disease who have epithelial ovarian (OC) or metastatic colorectal cancer (CRC): Phase 2 results [J]. Journal of Clinical Oncology, 2022, 40(suppl. 16): 2600.
[32]
Pouget JP, Navarro-teulon I, Bardiès M, et al. Clinical radioimmunotherapy--the role of radiobiology [J]. Nat Rev Clin Oncol, 2011, 8(12): 720-734.
[33]
Kinuya S, Li XF, Yokoyama K, et al. Intraperitoneal radioimmunotherapy in treating peritoneal carcinomatosis of colon cancer in mice compared with systemic radioimmunotherapy[J]. Cancer Sci, 2003, 94(7): 650-654.
[34]
Schoffelen R, Van Der Graaf WT, Sharkey RM, et al. Quantitative immuno-SPECT monitoring of pretargeted radioimmunotherapy with a bispecific antibody in an intraperitoneal nude mouse model of human colon cancer [J]. J Nucl Med, 2012, 53(12): 1926-1932.
[35]
Chandler CS, Bell MM, Chung SK, et al. Intraperitoneal pretargeted radioimmunotherapy for colorectal peritoneal carcinomatosis [J]. Mol Cancer Ther, 2022, 21(1): 125-137.
[36]
Hallqvist A, Bergmark K, Bäck T, et al. Intraperitoneal α-emitting radioimmunotherapy with (211)at in relapsed ovarian cancer: long-term follow-up with individual absorbed dose estimations [J]. J Nucl Med, 2019, 60(8): 1073-1079.
[37]
Modak S, Zanzonico P, Grkovski M, et al. B7H3- directed intraperitoneal radioimmunotherapy with radioiodinated omburtamab for desmoplastic small round cell tumor and other peritoneal tumors: results of a phase I study [J]. J Clin Oncol, 2020, 38(36): 4283-4291.
[38]
Heiss MM, Murawa P, Koralewski P, et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial [J]. Int J Cancer, 2010, 127(9): 2209-2221.
[39]
Ströhlein MA, Lordick F, Rüttinger D, et al. Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: an open-label, multicenter, phase I/II trial [J]. Onkologie, 2011, 34(3): 101-108.
[40]
Ströhlein MA, Heiss MM, Jauch KW. The current status of immunotherapy in peritoneal carcinomatosis [J]. Expert Rev Anticancer Ther, 2016, 16(10): 1019-1027.
[41]
Frøysnes IS, Andersson Y, Larsen SG, et al. Novel treatment with intraperitoneal MOC31PE immunotoxin in colorectal peritoneal metastasis: results from the ImmunoPeCa phase 1 trial [J]. Ann Surg Oncol, 2017, 24(7): 1916-1922.
[42]
Frøysnes IS, Andersson Y, Larsen SG, et al. ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis [J]. Eur J Surg Oncol, 2021, 47(1): 134-138.
[43]
Hong M, Clubb JD, Chen YY. Engineering CAR-T cells for next-generation cancer therapy [J]. Cancer Cell, 2020, 38(4): 473-488.
[44]
Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia [J]. N Engl J Med, 2014, 371(16): 1507-1517.
[45]
Katz SC, Point GR, Cunetta M, et al. Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery [J]. Cancer Gene Ther, 2016, 23(5): 142-148.
[46]
Qian S, Villarejo-campos P, García-olmo D. The role of CAR-T cells in peritoneal carcinomatosis from gastric cancer: rationale, experimental work, and clinical applications[J]. J Clin Med, 2021, 10(21): 5050.
[47]
Ang WX, Li Z, Chi Z, et al. Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis [J]. Oncotarget, 2017, 8(8): 13545-13559.
[48]
Xiao L, Cen D, Gan H, et al. Adoptive transfer of NKG2D CAR mRNA-engineered natural killer cells in colorectal cancer patients [J]. Mol Ther, 2019, 27(6): 1114-1125.
[49]
Li Z, Chi Z, Ang WX, et al. Experimental treatment of colorectal cancer in mice with human T cells electroporated with NKG2D RNA CAR [J]. Immunotherapy, 2020, 12(10): 733-748.
[50]
Newick K, O'brien S, Moon E, et al. CAR T cell therapy for solid tumors[J]. Annu Rev Med, 2017, 68(1): 39-52.
[1] 康夏, 田浩, 钱进, 高源, 缪洪明, 齐晓伟. 骨织素抑制破骨细胞分化改善肿瘤骨转移中骨溶解的机制研究[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 329-339.
[2] 代莉, 邓恢伟, 郭华静, 黄芙蓉. 术中持续输注艾司氯胺酮对腹腔镜结直肠癌手术患者术后睡眠质量的影响[J]. 中华普通外科学文献(电子版), 2023, 17(06): 408-412.
[3] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[4] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[5] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[6] 李婷, 张琳. 血清脂肪酸代谢物及维生素D水平与结直肠癌发生的关系研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 661-665.
[7] 魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.
[8] 关旭, 王锡山. 基于外科与免疫视角思考结直肠癌区域淋巴结处理的功与过[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 448-452.
[9] 顾睿祈, 方洪生, 蔡国响. 循环肿瘤DNA检测在结直肠癌诊治中的应用与进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 453-459.
[10] 倪文凯, 齐翀, 许小丹, 周燮程, 殷庆章, 蔡元坤. 结直肠癌患者术后发生延迟性肠麻痹的影响因素分析[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 484-489.
[11] 范小彧, 孙司正, 鄂一民, 喻春钊. 梗阻性左半结肠癌不同手术治疗方案的选择应用[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 500-504.
[12] 胡宝茹, 尚乃舰, 高迪. 中晚期肝细胞癌的DCE-MRI及DWI表现与免疫治疗预后的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 399-403.
[13] 孙昕, 程海波, 沈卫星. 基于全转录组学探讨仙连解毒方治疗Ⅲ期结直肠癌患者的疗效机制[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 277-283.
[14] 杨镠, 秦岚群, 耿茜, 李栋庆, 戚春建, 蒋华. 可溶性免疫检查点对胃癌患者免疫治疗疗效和预后的预测价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 305-311.
[15] 符梅沙, 周玉华, 李慧, 薛春颜. 淋巴细胞免疫治疗对复发性流产患者外周血T淋巴细胞亚群分布与PD1/PD-L1表达的影响及意义[J]. 中华临床医师杂志(电子版), 2023, 17(06): 726-730.
阅读次数
全文


摘要