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中华结直肠疾病电子杂志 ›› 2021, Vol. 10 ›› Issue (05) : 476 -481. doi: 10.3877/cma.j.issn.2095-3224.2021.05.005

论著

首荟通便胶囊在右半结肠切除手术肠道准备中的作用研究
陈佳楠1, 陈海鹏1,(), 王玲玲1, 刘正1,(), 刘骞1   
  1. 1. 100021 北京,国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科
  • 收稿日期:2021-07-22 出版日期:2021-10-25
  • 通信作者: 陈海鹏, 刘正
  • 基金资助:
    国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项项目(2018YFC1312100); 北京协和医学院一流学科建设项目(201920200304)

Observation on the efficacy of Shouhui Tongbian Capsule in preoperative bowel preparation for right colon cancer

Jia'nan Chen1, Haipeng Chen1,(), Lingling Wang1, Zheng Liu1,(), Qian Liu1   

  1. 1. Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China
  • Received:2021-07-22 Published:2021-10-25
  • Corresponding author: Haipeng Chen, Zheng Liu
引用本文:

陈佳楠, 陈海鹏, 王玲玲, 刘正, 刘骞. 首荟通便胶囊在右半结肠切除手术肠道准备中的作用研究[J/OL]. 中华结直肠疾病电子杂志, 2021, 10(05): 476-481.

Jia'nan Chen, Haipeng Chen, Lingling Wang, Zheng Liu, Qian Liu. Observation on the efficacy of Shouhui Tongbian Capsule in preoperative bowel preparation for right colon cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(05): 476-481.

目的

评估首荟通便胶囊在右半结肠癌患者术前肠道准备中的效果及可行性。

方法

回顾性分析2018年7月至2019年10月期间就诊于中国医学科学院肿瘤医院结直肠外科并进行手术治疗的右半结肠癌患者的临床资料,分为研究组和对照组,其中研究组130例,对照组132例。研究组应用首荟通便胶囊行术前肠道准备,对照组口服复方聚乙二醇电解质散行术前肠道清洁准备。分析两组患者肠道准备耐受性,术中肠道清洁度、不良反应、术后并发症、肝肾功能及电解质水平的差异。

结果

两组患者在肠道清洁度、术后并发症、肝肾功能及电解质水平等方面相比较差异均无统计学意义(均P>0.05),然而研究组患者在术前肠道准备中具有更好的耐受性(χ2=12.405,P<0.001),不良反应率低(χ2=15.732,P<0.001)。

结论

首荟通便胶囊用于右半结肠癌术前肠道准备中具有良好的安全性及耐受性,不增加术后感染等并发症的发生,可用于右半结肠癌术前准备中。

Objective

To evaluate the effect and feasibility of Shouhui Tongbian Capsule in preoperative bowel preparation for patients with right colon cancer.

Methods

The clinical data of patients with right colon cancer who were treated in National Cancer Center from July 2018 to October 2019 were retrospectively analyzed. 262 patients with right colon cancer were divided into study group and control group, the Shouhui Tongbian Capsule group (130 cases), who received Shouhui Tongbian Capsule for preoperative bowel preparation, and the control group (132 cases), who were given compound polyethylene glycol electrolyte powder for preoperative bowel cleaning. The differences of preoperative intestinal preparation tolerance score, intraoperative intestinal cleaning score, adverse reactions, postoperative complications, hepatic and renal function, electrolytes between the two groups were analyzed.

Results

There were no significant differences in cleaning score, incidence of postoperative complications, hepatic and renal function, and electrolytes between the two groups (all P>0.05), but the study group had better tolerance in preoperative intestinal preparation (χ2=12.405,P<0.001) and lower adverse reactions (χ2=15.732,P<0.001).

Conclusion

Shouhui Tongbian Capsule has good safety and tolerance in preoperative bowel preparation for right colon cancer patients, and does not increase the incidence of postoperative infection and other complications.

表1 患者一般资料[例(%)]
表2 两组患者肠道准备结果及术后相关并发症情况[例(%)]
表3 两组患者肠道准备前、后血液及肝肾功能对比
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