系统性红斑狼疮（SLE）是一种自身免疫性疾病，SLE合并消化系统受累在临床上较为常见。狼疮性肠系膜血管炎（LMV）是SLE累及消化道的主要表现形式，但它所引起的腹痛等消化道症状却因症状体征轻、特异性低不易被临床医生所重视。本例SLE患者反复腹痛近20年，先后出现升结肠和乙状结肠的节段性病变伴慢性穿孔及梗阻，均通过外科手术治疗及术后病理得以证实，较为罕见。

Systemic lupus erythematosus (SLE) is an autoimmune disease. SLE combined with digestive system involvement is a common clinical disease. Lupus mesenteric vasculitis (LMV) is the main manifestation of the accumulated digestive tract in SLE, but the gastrointestinal symptoms such as abdominal pain caused by LMV are not easy to be valued by clinicians due to their mild symptoms and low specificity. This patient with SLE had recurrent abdominal pain for nearly 20 years. Segmental lesions and chronic perforation in the ascending colon and sigmoid colon occurred successively, which were confirmed by surgical treatment and postoperative pathology. And this was a rare case.