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中华结直肠疾病电子杂志 ›› 2020, Vol. 09 ›› Issue (06) : 597 -604. doi: 10.3877/cma.j.issn.2095-3224.2020.06.011

所属专题: 文献

论著

基于CT增强对肠系膜侵袭性纤维瘤病和胃肠道间质瘤的鉴别诊断
张大福1, 代佑果2, 杨光军1, 张治平1, 李振辉1,()   
  1. 1. 650118 昆明医科大学第三附属医院/云南省肿瘤医院放射科
    2. 650118 昆明医科大学第三附属医院/云南省肿瘤医院胃与小肠外科
  • 收稿日期:2020-07-10 出版日期:2020-12-25
  • 通信作者: 李振辉
  • 基金资助:
    云南省科技厅-昆明医科大学应用基础研究联合专项基金(No. 2019FE001(-083),No. 2019FE001(-084)); 云南省教育厅面上项目(No. 2018JS223,No. 2018JS230)

The differential diagnosis of mesenteric invasive fibromatosis and gastrointestinal stromal tumor based on CT enhancement

Dafu Zhang1, Youguo Dai2, Guangjun Yang1, Zhiping Zhang1, Zhenhui Li1,()   

  1. 1. Department of Radiology, the Third Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118, China
    2. Department of Gastrointestinal Surgery, the Third Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118, China
  • Received:2020-07-10 Published:2020-12-25
  • Corresponding author: Zhenhui Li
  • About author:
    Corresponding author: Li Zhenhui, Email:
引用本文:

张大福, 代佑果, 杨光军, 张治平, 李振辉. 基于CT增强对肠系膜侵袭性纤维瘤病和胃肠道间质瘤的鉴别诊断[J/OL]. 中华结直肠疾病电子杂志, 2020, 09(06): 597-604.

Dafu Zhang, Youguo Dai, Guangjun Yang, Zhiping Zhang, Zhenhui Li. The differential diagnosis of mesenteric invasive fibromatosis and gastrointestinal stromal tumor based on CT enhancement[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2020, 09(06): 597-604.

目的

探讨肠系膜侵袭性纤维瘤病(MAF)与胃肠道间质瘤(GIST)的CT鉴别特征。

方法

回顾性分析53例经病理证实的MAF(14例)和GIST(39例)的CT表现。对病灶的位置、形态和边界、强化方式、病灶内坏死、血管和空气、钙化等征象进行分析。测量长径(LD)、短径(SD)、CT值,并计算LD/SD比值、强化程度。采用t检验和受试者操作特征(ROC)曲线确定有意义的CT征象。当使用单一或多个CT特征时,计算敏感度和特异度。

结果

MAF多位于胃肠道外(χ2=10.437,P=0.001)、卵圆形或不规则形(χ2=9.192,P=0.004)、强化均匀(χ2=12.458,P=0.000)、病灶内无坏死(χ2=6.632,P=0.014)及强化程度低(静脉期增加CT值约23.9±8.2 HU)。当联合强化均匀和LD/SD比值诊断MAF的敏感度和特异度分别为92.9%和97.4%。

结论

胃肠外肠系膜、卵圆形或不规则形、均匀强化、病灶内无坏死、LD/SD≥1.19、动脉期强期增加CT值≤22 HU、静脉期强期增加CT值≤31 HU等7个CT指标有助于鉴别MAF与GIST。

Objective

To investigate the CT differential features of mesenteric invasive fibromatosis (MAF) and gastrointestinal stromal tumor (GIST).

Methods

CT images of 53 pathologically proven cases of MAF (n=14) and GIST (n=39) were retrospectively reviewed. Location, contour, border, enhancement pattern, presence of necrosis, vessels, and air within the lesion were analyzed. Long diameter (LD), short diameter (SD), LD/SD ratio, degree of enhancement were measured and calculated. Significant CT criteria were identified using t-test, and receiver operating characteristic (ROC) curve. Sensitivity and specificity values were calculated when single or multiple CT criteria were used.

Results

Most of the MAF were extra-gastrointestinal location (χ2=10.437, P=0.001), oval or irregular (χ2=9.192, P=0.004), homogeneous enhancement (χ2=12.458, P=0.000), absence of intra-lesional necrosis (χ2=6.632, P=0.014), lower degree of enhancement (the CT value of venous phase was 23.9±8.2 HU). When homogeneous enhancement and LD/SD ratio were combined, the sensitivity and specificity for diagnosing MAF were 92.9% and 97.4%, respectively.

Conclusion

The following seven CT features are helpful to distinguish MAF from GIST: extra-gastrointestinal location, oval or irregular shape, homogeneous enhancement, absence of intra-lesional necrosis, LD/SD≥1.19, increased CT value≤22 HU in arterial phase and CT value ≤31 HU in arterial phase.

图1 男性,55岁,MAF。1A:轴位平扫显示卵圆形均匀肿块,边界清楚,LD/SD=1.29,亦提示肿块为卵圆形。1B(动脉期)和1C(静脉期)轴位增强CT图像显示均匀强化的肿块,内见血管影(箭头),病灶内无坏死。与邻近肠管分界清楚,提示肿块来自胃肠外。动脉期和门静脉期的强化程度分别为9 HU和11 HU,提示病灶轻度强化(AP值和PP值<20 HU)
图2 男性,47岁,MAF。2A:轴位平扫显示卵圆形均匀肿块,边界清楚,LD/SD=1.21,亦提示肿块为卵圆形。2B(动脉期)和2C(静脉期)轴位增强CT图像显示均匀强化的肿块,病灶内无坏死。与邻近肠管分界清楚,提示肿块来自胃肠外。动脉期和门静脉期的强化程度分别为16 HU和20 HU,提示病灶轻度强化
图3 男性,56岁,腹腔GIST。3A:轴位平扫显示分圆形、不均匀的肿块。3B(动脉期)和3C(门静脉期)轴位增强CT图像显示明显的不均匀强化肿块伴病灶内坏死(如白星所示,低密度区平扫CT值约29 HU,增强动脉期约28 HU,静脉期约30 HU,提示低密度区不强化)。动脉期和静脉期的强化程度分别为100 HU和60 HU,提示显著不均匀强化(AP值和PP值≥40 HU)
图4 女性,59岁,空肠GIST。4A:轴位平扫显示分分叶状、不均匀的肿块,内见钙化(细箭)。4B(动脉期)和4C(门静脉期)轴位增强CT图像显示明显的不均匀强化肿块伴病灶内不规则条片状坏死(粗箭,低密度区不增强)。动脉期和静脉期的强化程度分别为50 HU和60 HU,提示显著不均匀强化(AP值和PP值≥40 HU)
表1 MAF与GIST的定性图像分析结果
表2 MAF与GIST的定量图像分析结果(±s
图5 ROC曲线图。5A:动脉期强化程度(AP)、静脉期强化程度(PP)的ROC曲线图以鉴别MAF与GIST,ROC曲线下面积分别为0.842(AP)、0.761(PP)。5B:LD/SD率的ROC曲线图以鉴别MAF与GIST,ROC曲线下面积为0.886
表3 MAF和GIST的每个重要CT征像的敏感度和特异度
图6 显示联合强化均匀和LD/SD率的ROC曲线图以鉴别MAF与GIST,ROC曲线下面积为0.984
表4 回归方程中的变量
表5 未包括在方程中的变量
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