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中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (01) : 58 -62. doi: 10.3877/cma.j.issn.2095-3224.2019.01.011

所属专题: 文献

论著

二甲双胍与结直肠腺瘤患病风险相关性的荟萃分析
胡悦1, 金武勇1, 孙超2, 孙昕1,()   
  1. 1. 830054 乌鲁木齐,新疆医科大学第四附属医院外一科三组
    2. 710032 西安,空军军医大医院老年病科
  • 收稿日期:2017-10-20 出版日期:2019-02-25
  • 通信作者: 孙昕

Metformin use and the risk of colorectal adenoma: a systematic review and meta-analysis

Yue Hu1, Wuyong Jin1, Chao Sun2, Xin Sun1,()   

  1. 1. Department of Surgery the Third Groups, the Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
    2. Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi′an 710032, China
  • Received:2017-10-20 Published:2019-02-25
  • Corresponding author: Xin Sun
  • About author:
    Corresponding author: Sun Xin, Email:
引用本文:

胡悦, 金武勇, 孙超, 孙昕. 二甲双胍与结直肠腺瘤患病风险相关性的荟萃分析[J/OL]. 中华结直肠疾病电子杂志, 2019, 08(01): 58-62.

Yue Hu, Wuyong Jin, Chao Sun, Xin Sun. Metformin use and the risk of colorectal adenoma: a systematic review and meta-analysis[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(01): 58-62.

目的

探索糖尿病患者服用二甲双胍是否可降低患结肠直肠腺瘤的风险。

方法

从PubMed、Elsevier-ScienceDirect、万方、维普数据库中检索建库以来至2017年7月所有关于2型糖尿病患者使用二甲双胍与患结直肠腺瘤风险相关性的研究。按照纳入及排除标准选择入选。

结果

共计纳入9项研究,其中实验组4 256例,对照组17 206例,结果显示,服用二甲双胍者较未服用二甲双胍者患结直肠腺瘤风险降低(OR=0.83,95%CI:0.72~0.95;P=0.008),差异具有统计学意义。

结论

二甲双胍的使用可能与结肠直肠腺瘤的风险降低有关。

Objective

To explore whether the use of metformin can reduce the risk of colorectal adenoma in diabetic patients.

Methods

We conducted a systematic literature search on PubMed, Elsevier-Science Direct, Wanfang, Wipu database to retrieve the database about correlation between the use of metformin in patients with type 2 diabetes and the risk of colorectal adenoma since the construction to July 2017.

Results

Finally, nine articles were included in our study, including experimental group 4256 cases, the control group 17 206 cases, The results showed that the risk of colorectal adenoma in patients taking metformin was significantly lower than those not taking metformin (OR=0.83, 95%CI 0.72~0.95, P=0.008), the difference was statistically significant.

Conclusion

The use of metformin may be associated with a reduced risk of colorectal adenoma.

表1 纳入文献的基本特征及评分
图1 文献筛选流程及结果
图2 结直肠腺瘤在服用、未服用二甲双胍者中患病人数比较的Meta分析结果
图3 Meta分析结果的漏斗图
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