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中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (01) : 63 -66. doi: 10.3877/cma.j.issn.2095-3224.2019.01.012

所属专题: 文献

综述

晚期结直肠癌维持治疗现状及生存获益人群的探索
侯玲1, 刘静1,(), 刘云鹏1   
  1. 1. 110001 沈阳,中国医科大学附属第一医院肿瘤内科
  • 收稿日期:2017-03-23 出版日期:2019-02-25
  • 通信作者: 刘静
  • 基金资助:
    辽宁省科学技术计划项目(No.2014226033,No.2014225013); 辽宁省中央引导地方科技发展专项资金(No.2016007010)

Current status of maintenance treatment for metastatic colorectal cancer and characteristics of population with survival benefit

Ling Hou1, Jing Liu1,(), Yunpeng Liu1   

  1. 1. Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China
  • Received:2017-03-23 Published:2019-02-25
  • Corresponding author: Jing Liu
  • About author:
    Corresponding author: Liu Jing, Email:
引用本文:

侯玲, 刘静, 刘云鹏. 晚期结直肠癌维持治疗现状及生存获益人群的探索[J]. 中华结直肠疾病电子杂志, 2019, 08(01): 63-66.

Ling Hou, Jing Liu, Yunpeng Liu. Current status of maintenance treatment for metastatic colorectal cancer and characteristics of population with survival benefit[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(01): 63-66.

维持治疗是指一线诱导治疗后获益的患者,为取得生存获益的同时尽可能保证生活质量,停用某些毒性明显的药物,而保留低强度、低毒性药物的一种治疗模式。多项研究表明,经一线诱导治疗后获益的晚期结直肠癌患者,采用维持治疗可延长疾病无进展生存期(PFS),但尚无充分证据证明维持治疗能延长总生存期(OS)。维持治疗采取何种方案最优,具备哪些特征的人群能从维持治疗中取得更大的生存获益,尚不完全清楚。本文就晚期结直肠癌维持治疗现状及对生存获益人群的探索做一综述。

Maintenance treatment is the strategy aimed to ensure the quality of life meanwhile improve survival with low toxicity drugs after induction treatment. Several studies showed that maintenance therapy could prolong progression free survival (PFS) of patients with metastatic colorectal cancer, but there is no clear evidence to prove that the maintenance treatment could prolong overall survival (OS). It is not clear that which scheme is optimal for maintenance, what characteristics carried by the patients could get more survival benefit from maintenance treatment. We reviewed the current status of maintenance treatment in metastatic colorectal cancer and explore the population who can benefit from maintenance treatment best.

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