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中华结直肠疾病电子杂志 ›› 2017, Vol. 06 ›› Issue (05) : 407 -409. doi: 10.3877/cma.j.issn.2095-3224.2017.05.011

所属专题: 文献

综述

PD-1检查点抑制剂治疗中相关的心脏不良反应
祁玲1, 黄镜1,()   
  1. 1. 100021 北京,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院肿瘤内科
  • 收稿日期:2017-02-18 出版日期:2017-10-25
  • 通信作者: 黄镜

Cardiotoxicity associated with PD-1 blocking therapy

Ling Qi1, Jing Huang1,()   

  1. 1. Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2017-02-18 Published:2017-10-25
  • Corresponding author: Jing Huang
  • About author:
    Corresponding author: Huang Jing, Email:
引用本文:

祁玲, 黄镜. PD-1检查点抑制剂治疗中相关的心脏不良反应[J]. 中华结直肠疾病电子杂志, 2017, 06(05): 407-409.

Ling Qi, Jing Huang. Cardiotoxicity associated with PD-1 blocking therapy[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2017, 06(05): 407-409.

PD-1检查点抑制剂已在结直肠癌治疗中得到客观的疗效,与之伴随的免疫相关的多种不良反应也逐渐引起大家的重视。其中最常见的瘙痒症、甲状腺功能减退、甲状腺功能亢进等多项靶向药物的不良反应已有明确的研究报道。在强调疗效的同时,严重不良反应对预后是否产生严重影响在免疫治疗中也显得尤为重要。本文就PD-1检查点抑制剂治疗相关的心脏不良反应做一简要综述。

PD-1 checkpoint blocking has been demonstrated objective efficacy in dMMR colorectal tumors, meanwhile more attention has been focused on immune-related adverse event. As hypothyroidism, hyperthyroidism and pruritus are most frequent compared to standard of care approaches have been reported, it should be emphasized that whether serious adverse reactions could affects the prognosis severely in immune treatment while we maximize the curative effect. This review summarizes the cardiotoxicity associated with PD-1 blocking therapy.

[1]
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy[J]. Nat Rev Cancer, 2012, 12(4):252-264.
[2]
Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion[J]. Nature Med, 1999, 5(12), 1365-1369.
[3]
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion[J]. Nature Med, 2002, 8(8), 793–800.
[4]
Blank C, Kuball J, Voelkl S, et al. Blockade of PD-L1(B7-H1) augments human tumor-specific T cell responses in vitro[J]. Int J Cancer, 2006, 119(2):317-327.
[5]
Costa R, Carneiro BA, Agulnik M, et al. Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials[J]. Oncotarget, 2017, 8(5):8910-8920.
[6]
Heinzerling L, Ott PA, Hodi FS, et al. Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy[J]. J Immunother Cancer, 2016, 16(4):50.
[7]
Läubli H, Balmelli C, Bossard M, et al. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma[J]. J Immunother Cancer, 2015, 21(3):11.
[8]
Zimmer L, Goldinger SM, Hofmann L, et al. Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy[J]. Eur J Cancer, 2016, 60(6):210-225.
[9]
Moslehi JJ. Cardiovascular Toxic Effects of Targeted Cancer Therapies[J]. N Engl J Med, 2016, 375(15):1457-1467.
[10]
Grabie N, Gotsman I, DaCosta R, et al. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart[J]. Circulation, 2007, 116(18):2062-2071.
[11]
Tarrio ML, Grabie N, Bu DX, et al. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis[J]. J Immunol, 2012, 188(10):4876-4884.
[12]
Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice[J]. Science, 2001, 291(5502):319-322.
[13]
Okazaki T, Tanaka Y, Nishio R, et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice[J]. Nat Med, 2003, 9(12):1477-1483.
[14]
Goser S, Andrassy M, Buss SJ, et al. Cardiac troponin I but not cardiac troponin T induces severe autoimmune in- flammation in the myocardium[J]. Circulation, 2006, 114(16):1693.
[15]
Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application[J]. Int Immunol, 2007, 19(7):813-824.
[16]
Lucas JA, Menke J, Rabacal WA, et al. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice[J]. J Immunol, 2008, 181(4):2513-2521.
[17]
Wang J, Okazaki IM, Yoshida T, et al. PD-1 deficiency results in the development of fatal myocarditis in MRL mice[J]. Int Immunol, 2010, 22(6):443-452.
[18]
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, et al. ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines[J]. European Heart Journal, 2016, 37(36):2768-2801.
[19]
Bielecka-Dabrowa A, Mikhailidis DP, Hannam S, et al. Takotsubo cardiomyopathy-the current state of knowledge[J]. Int J Cardiol, 2010, 142(2):120-125.
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