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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (06) : 518 -522. doi: 10.3877/cma.j.issn.2095-3224.2016.06.013

所属专题: 文献

综述

长链非编码RNA在结直肠癌中的研究现状
梁新军1,(), 臧爱华1   
  1. 1. 430079 武汉,湖北省肿瘤医院腹部内科
  • 收稿日期:2016-07-23 出版日期:2016-12-25
  • 通信作者: 梁新军
  • 基金资助:
    武汉市科技局科技计划资助项目(No.2013062301010813); 武汉市晨光计划资助项目(No.2015070404010204)

Research progress of long non-coding RNA in colorectal cancer

Xinjun Liang1,(), Aihua Zang1   

  1. 1. Department of Gastroenterology, Hubei Cancer Hospital, Wuhan 430071, China
  • Received:2016-07-23 Published:2016-12-25
  • Corresponding author: Xinjun Liang
  • About author:
    Corresponding author: Liang Xinjun, Email:
引用本文:

梁新军, 臧爱华. 长链非编码RNA在结直肠癌中的研究现状[J]. 中华结直肠疾病电子杂志, 2016, 05(06): 518-522.

Xinjun Liang, Aihua Zang. Research progress of long non-coding RNA in colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(06): 518-522.

近年来研究发现,长链非编码RNA在多种恶性肿瘤的发生发展中发挥重要作用,有望成为新的肿瘤治疗靶点,已成为目前肿瘤研究的热点问题之一。本文对长链非编码RNA的概况及其在结直肠癌预后判断、恶性潜能及诊断中的应用现状做一综述,为结直肠癌的精准治疗提供新的思路与依据。

As long non-coding RNA plays an important role in the occurrence and development of a variety of malignant tumors, it has become one of the extensively attended issues in cancer research and is expected to become a new target for tumor therapy. In this review, we outlined the biological characteristics of long non-coding RNA and its application in prognostic value, malignant potential and diagnosis of colorectal cancer, which will provide a new idea and basis for the accurate treatment of colorectal cancer.

[1]
Goldstein DA,Ahmad BB,Chen Q, et al. Cost-Effectiveness Analysis of Regorafenib for Metastatic Colorectal Cancer[J]. J ClinOncol, 2015, 33(32): 3727-3732.
[2]
Chibaudel B,Bonnetain F,Tournigand C, et al. Maintenance treatment in metastatic colorectal cancer[J]. Lancet Oncol, 2015, 16(16): e583-584.
[3]
Huarte M. The emerging role of lncRNAs in cancer[J]. Nat Med, 2015, 21(11): 1253-1261.
[4]
Ruan X. Long non-coding RNA central of glucose homeostasis[J]. J Cell Biochem, 2016, 117(5): 1061-1065.
[5]
Bhan A,Mandal SS. LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer[J]. Biochim Biophys Acta, 2015, 1856(1): 151-164.
[6]
Shahryari A,Jazi MS,Samaei NM, et al. Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis[J]. Front Genet, 2015, 6: 196.
[7]
Liz J,Esteller M. lncRNAs and microRNAs with a role in cancer development[J]. Biochim Biophys Acta, 2016, 1859(1): 169-176.
[8]
Wu T,Yin X,Zhou Y, et al. Roles of noncoding RNAs in metastasis of nonsmall cell lung cancer: A mini review[J]. J Cancer Res Ther, 2015, Suppl 1: C7-10.
[9]
Malih S,Saidijam M,Malih N. A brief review on long noncoding RNAs: a new paradigm in breast cancer pathogenesis, diagnosis and therapy[J]. Tumour Biol, 2016, 37(2): 1479-1485.
[10]
Shih JW,Wang LY,Hung CL, et al. Non-coding RNAs in castration-resistant prostate cancer: regulation of androgen receptor signaling and cancer metabolism[J]. Int J Mol Sci, 2015, 16(12): 28943-28978.
[11]
Shi X,Sun M,Liu H, et al. Long non-coding RNAs: a new frontier in the study of human diseases[J]. Cancer Lett, 2013, 339(2): 159-166.
[12]
Guo F,Guo L,Li Y, et al. MALAT1 is an oncogenic long non-coding RNA associated with tumor invasion in non-small cell lung cancer regulated by DNA methylation[J]. Int J Clin Exp Pathol, 2015, 8(12): 15903-15910.
[13]
Konishi H,Ichikawa D,Yamamoto Y, et al. Plasma level of metastasis-associated lung adenocarcinoma transcript 1 is associated with liver damage and predicts development of hepatocellular carcinoma[J]. Cancer Sci, 2016, 107(2): 149-154.
[14]
Xiao H,Tang K,Liu P, et al. LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma[J]. Oncotarget, 2015, 6(35): 38005-38015.
[15]
Zheng HT,Shi DB,Wang YW, et al. High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer[J]. Int J Clin Exp Pathol, 2014, 7(6): 3174-3181.
[16]
Wu S,Zheng C,Chen S, et al. Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acutebmyeloidleukemia[J]. Oncol Lett, 2015, 10(4): 2410-2414.
[17]
Wang YL,Overstreet AM,Chen MS, et al. Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR[J]. Oncotarget, 2015, 6(13): 11150-11161.
[18]
Wang Y,Wang H,Song T, et al. HOTAIR is a potential target for the treatment of cisplatin resistant ovarian cancer[J]. Mol Med Rep, 2015, 12(2): 2211-2216.
[19]
Svoboda M,Slyskova J,Schneiderova M, et al. HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients[J]. Carcinogenesis, 2014, 35(7): 1510-1515.
[20]
Wu ZH,Wang XL,Tang HM, et al. Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer[J]. Oncol Rep, 2014, 32(1): 395-402.
[21]
Yue B,Sun B,Liu C, et al. Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer[J]. Cancer Sci, 2015, 106(10): 1323-1332.
[22]
Yue B,Qiu S,Zhao S, et al. LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis[J]. J Gastroenterol Hepatol, 2016, 31(3): 595-603.
[23]
Yan B,Gu W,Yang Z, et al. Down regulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectalcancer[J]. Tumour Biol, 2014, 35(11): 11329-11335.
[24]
Ren YK,Xiao Y,Wan XB, et al. Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer[J]. Int J Clin Exp Pathol, 2015, 8(9): 11458-11463.
[25]
He X,Tan X,Wang X, et al. C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion[J]. Tumour Biol, 2014, 35(12): 12181-12188.
[26]
Qi P,Xu MD,Ni SJ, et al. Down-regulation of ncRAN, a long non-coding RNA, contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients[J]. Mol Carcinog, 2015, 54(9): 742-750.
[27]
Yuan Z,Yu X,Ni B, et al. Overexpression of long non-coding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/β-catenin signaling and predicts favorable prognosis[J]. Int J Oncol, 2016, 48(6): 2675-2685.
[28]
Thorenoor N,Faltejskova-Vychytilova P,Hombach S, et al. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer[J]. Oncotarget, 2016, 7(1): 622-637.
[29]
Sun L,Xue H,Jiang C, et al. LncRNA DQ786243 contributes to proliferation and metastasis of colorectal cancer both in vitro and in vivo[J]. 2016, 36(3): pii: e00328.
[30]
Zhang ZY,Lu YX,Zhang ZY, et al. Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer[J]. Oncotarget, 2016, 7(16): 22639-22649.
[31]
Bian Z,Jin L,Zhang J, et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p[J]. SCI Rep, 2016, 6: 23892.
[32]
Xiong W,Jiang YX,Ai YQ, et al. Microarray analysis of long non-coding RNA expression profile associated with 5-Fluorouracil-based chemoradiation resistance in colorectal cancer cells[J]. Asian Pac J Cancer Prev, 2015, 16(8): 3395-3402.
[33]
徐小雯,袁捷,左志贵, 等. 与放疗抵抗相关的长链非编码RNA在不同放疗敏感性结直肠癌细胞株中的表达[J]. 中华胃肠外科杂志, 2014, 17(11): 1096-1101.
[34]
Sun QL,Zhao CP,Wang TY, et al. Expression profile analysis of long non-coding RNA associated with vincristine resistance in colon cancer cells by next-generation sequencing[J]. Gene, 2015, 572(1): 79-86.
[35]
Zhao W,Song M,Zhang J, et al. Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma[J]. Int J Clin Exp Pathol, 2015, 8(11): 14131-14140.
[36]
Kam Y,Rubinstein A,Naik S, et al. Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons[J]. Cancer Lett, 2014, 352(1): 90-96.
[37]
Tao K,Yang J,Hu Y, et al. Clinical significance of urothelial carcinoma associated 1 in colon cancer[J]. Int J Clin Exp Med, 2015, 8(11): 21854-21860.
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