切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (01) : 47 -51. doi: 10.3877/cma.j.issn.2095-3224.2016.01.09

所属专题: 文献

论著

Caveolin-1在结直肠癌组织间质中的表达及临床意义
赵志1, 韩方海2,()   
  1. 1. 541000 桂林医学院附属医院胃肠外科
    2. 510120 广州,中山大学孙逸仙纪念医院胃肠外科
  • 收稿日期:2016-01-18 出版日期:2016-02-25
  • 通信作者: 韩方海
  • 基金资助:
    国家自然科学基金(81572925)

The expression and clinical significance of caveolin-1 in colorectal cancer stroma

Zhi Zhao1, Fanghai Han2,()   

  1. 1. Department of Gastrointestinal Surgery, Guilin Medical College Affiliated Hospital, Guilin 541000, China
    2. Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
  • Received:2016-01-18 Published:2016-02-25
  • Corresponding author: Fanghai Han
  • About author:
    Corresponding author:Han Fanghai, Email:
引用本文:

赵志, 韩方海. Caveolin-1在结直肠癌组织间质中的表达及临床意义[J]. 中华结直肠疾病电子杂志, 2016, 05(01): 47-51.

Zhi Zhao, Fanghai Han. The expression and clinical significance of caveolin-1 in colorectal cancer stroma[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(01): 47-51.

目的

探讨小凹蛋白(Caveolin-1,Cav-1)在结直肠癌组织中的表达及临床意义。

方法

收集在我院手术的结直肠癌患者110例,用免疫组化的方法检测Cav-1蛋白的表达。

结果

Cav-1阳性表达于肿瘤细胞的胞浆或胞膜上,低表达样本51例,高表达样本59例。Cav-1蛋白的表达与肿瘤N分期(P=0.011)及TNM分期密切相关(P=0.031)。Cav-1低表达患者的总体生存率及无进展生存率明显优于Cav-1高表达患者(P均小于0.001)。

结论

Cav-1或可以作为估计结直肠癌患者预后的指标之一,这也可能为结直肠癌患者的治疗提高新的方向。

Objective

To investigate the clinicopathological signi?cance and prognostic value of Caveolin-1 (Cav-1) in colorectal cancer (CRC).

Methods

A total of 110 patients with CRC were included in this study. The correlation between Cav-1 expression and clinicopathologic features and survival was studied.

Results

Cav-1 expression was detected in tumor cytoplasm and cytomembrane. The expression of Cav-1 was closely associated with pathologic (p) TNM stage (P=0.037) and pN stage (P=0.011). Moreover, Kaplan-Meier analysis showed that high Cav-1 expression was associated with shorter overall survival and disease free survival (P<0.001 for both). Multivariate analysis revealed that the Cav-1 expression was an independent prognostic factor for overall survival (P<0.014).

Conclusion

The expression of Cav-1 in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.

表1 Cav-1蛋白表达与患者临床病理的关系表
图1 Cav-1蛋白在结直肠癌组织中的表达
表2 单因素和多因素分析结直肠癌患者预后的因素表
图2 Kapian-meier方法分析患者的生存情况
图3 Western blot检测Cav-1在结直肠癌组织中的表达
[1]
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA: a cancer journal for clinicians, 2013, 63(1): 11-30.
[2]
Sinclair P, Singh A, Riaz AA, et al. An unsolved conundrum: the ideal follow-up strategy after curative surgery for colorectal cancer. Gastrointestinal endoscopy, 2012, 75(5): 1072-1079.
[3]
Kato K, Hida Y, Miyamoto M, et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer, 2002, 94(4): 929-933.
[4]
Suzuoki M, Miyamoto M, Kato K, et al. Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. British journal of cancer, 2002, 87(10): 1140-1144.
[5]
Cokakli M, Erdal E, Nart D, et al. Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion, BMC cancer, 2009; 9: 65.
[6]
Zhang ZB, Cai L, Zheng SG, et al. Overexpression of caveolin-1 in hepatocellular carcinoma with metastasis and worse prognosis: correlation with vascular endothelial growth factor, microvessel density and unpaired artery. Pathology oncology research: POR, 2009, 15(3): 495-502.
[7]
Capozza F, Williams TM, Schubert W, et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. The American journal of pathology, 2003, 162(6): 2029-2039.
[8]
Goetz JG, Lajoie P, Wiseman SM, et al. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer metastasis reviews, 2008, 27(4): 715-735.
[9]
El-Gendi SM, Mostafa MF, El-Gendi AM. Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcome. Pathology oncology research : POR, 2012, 18(2): 459-469.
[10]
Elsheikh SE, Green AR, Rakha EA, et al. Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype. British journal of cancer, 2008, 99(2): 327-334.
[11]
Karam JA, Lotan Y, Roehrborn CG, et al. Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence. The Prostate, 2007, 67(6): 614-622.
[12]
Joo HJ, Oh DK, Kim YS, et al. Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int, 2004, 93(3): 291-296.
[13]
Razani B, Altschuler Y, Zhu L, et al. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry, 2000, 39(45): 13916-13924.
[14]
Barresi V, Cerasoli S, Tuccari G. Correlative evidence that tumor cell-derived caveolin-1 mediates angiogenesis in meningiomas. Neuropathology : official journal of the Japanese Society of Neuropathology, 2008, 28(5): 472-478 .
[15]
Moon KC, Lee GK, Yoo SH, et al. Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. Anticancer research,2005, 25(6C): 4631-4637.
[16]
Choi HN, Kim KR, Park HS, et al. Expression of caveolin in hepatocellular carcinoma: association with unpaired artery formation and radiologic findings. The Korean journal of hepatology, 2007, 13(3): 396-408.
[17]
Zhou H, Jia L, Wang S, et al. Divergent expression and roles for caveolin-1 in mouse hepatocarcinoma cell lines with varying invasive ability. Biochem Biophys Res Commun, 2006, 345(1): 486-494.
[18]
Zhao X, Liu Y, Ma Q, et al. Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun, 2009, 378(1): 21-26.
[19]
Ho CC, Kuo SH, Huang PH, et al. Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy. Lung cancer, 2008, 59(1): 105-110.
[20]
Satoh T, Yang G, Egawa S, et al. Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients. Cancer, 2003, 97(5): 1225-1233.
[21]
Tang Y, Zeng X, He F, et al. Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer. Medical oncology, 2012, 29(2): 977-984.
[1] 应康, 杨璨莹, 刘凤珍, 陈丽丽, 刘燕娜. 左心室心肌应变对无症状重度主动脉瓣狭窄患者的预后评估价值[J]. 中华医学超声杂志(电子版), 2023, 20(06): 581-587.
[2] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[3] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[4] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[5] 杨倩, 李翠芳, 张婉秋. 原发性肝癌自发性破裂出血急诊TACE术后的近远期预后及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 33-36.
[6] 栗艳松, 冯会敏, 刘明超, 刘泽鹏, 姜秋霞. STIP1在三阴性乳腺癌组织中的表达及临床意义研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 52-56.
[7] 江振剑, 蒋明, 黄大莉. TK1、Ki67蛋白在分化型甲状腺癌组织中的表达及预后价值研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 623-626.
[8] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[9] 鲁鑫, 许佳怡, 刘洋, 杨琴, 鞠雯雯, 徐缨龙. 早期LC术与PTCD续贯LC术治疗急性胆囊炎对患者肝功能及预后的影响比较[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 648-650.
[10] 李婷, 张琳. 血清脂肪酸代谢物及维生素D水平与结直肠癌发生的关系研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 661-665.
[11] 倪文凯, 齐翀, 许小丹, 周燮程, 殷庆章, 蔡元坤. 结直肠癌患者术后发生延迟性肠麻痹的影响因素分析[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 484-489.
[12] 范小彧, 孙司正, 鄂一民, 喻春钊. 梗阻性左半结肠癌不同手术治疗方案的选择应用[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 500-504.
[13] 李永胜, 孙家和, 郭书伟, 卢义康, 刘洪洲. 高龄结直肠癌患者根治术后短期并发症及其影响因素[J]. 中华临床医师杂志(电子版), 2023, 17(9): 962-967.
[14] 王军, 刘鲲鹏, 姚兰, 张华, 魏越, 索利斌, 陈骏, 苗成利, 罗成华. 腹膜后肿瘤切除术中大量输血患者的麻醉管理特点与分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 844-849.
[15] 索利斌, 刘鲲鹏, 姚兰, 张华, 魏越, 王军, 陈骏, 苗成利, 罗成华. 原发性腹膜后副神经节瘤切除术麻醉管理的特点和分析[J]. 中华临床医师杂志(电子版), 2023, 17(07): 771-776.
阅读次数
全文


摘要