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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (01) : 47 -51. doi: 10.3877/cma.j.issn.2095-3224.2016.01.09

所属专题: 文献

论著

Caveolin-1在结直肠癌组织间质中的表达及临床意义
赵志1, 韩方海2,()   
  1. 1. 541000 桂林医学院附属医院胃肠外科
    2. 510120 广州,中山大学孙逸仙纪念医院胃肠外科
  • 收稿日期:2016-01-18 出版日期:2016-02-25
  • 通信作者: 韩方海
  • 基金资助:
    国家自然科学基金(81572925)

The expression and clinical significance of caveolin-1 in colorectal cancer stroma

Zhi Zhao1, Fanghai Han2,()   

  1. 1. Department of Gastrointestinal Surgery, Guilin Medical College Affiliated Hospital, Guilin 541000, China
    2. Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
  • Received:2016-01-18 Published:2016-02-25
  • Corresponding author: Fanghai Han
  • About author:
    Corresponding author:Han Fanghai, Email:
引用本文:

赵志, 韩方海. Caveolin-1在结直肠癌组织间质中的表达及临床意义[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(01): 47-51.

Zhi Zhao, Fanghai Han. The expression and clinical significance of caveolin-1 in colorectal cancer stroma[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(01): 47-51.

目的

探讨小凹蛋白(Caveolin-1,Cav-1)在结直肠癌组织中的表达及临床意义。

方法

收集在我院手术的结直肠癌患者110例,用免疫组化的方法检测Cav-1蛋白的表达。

结果

Cav-1阳性表达于肿瘤细胞的胞浆或胞膜上,低表达样本51例,高表达样本59例。Cav-1蛋白的表达与肿瘤N分期(P=0.011)及TNM分期密切相关(P=0.031)。Cav-1低表达患者的总体生存率及无进展生存率明显优于Cav-1高表达患者(P均小于0.001)。

结论

Cav-1或可以作为估计结直肠癌患者预后的指标之一,这也可能为结直肠癌患者的治疗提高新的方向。

Objective

To investigate the clinicopathological signi?cance and prognostic value of Caveolin-1 (Cav-1) in colorectal cancer (CRC).

Methods

A total of 110 patients with CRC were included in this study. The correlation between Cav-1 expression and clinicopathologic features and survival was studied.

Results

Cav-1 expression was detected in tumor cytoplasm and cytomembrane. The expression of Cav-1 was closely associated with pathologic (p) TNM stage (P=0.037) and pN stage (P=0.011). Moreover, Kaplan-Meier analysis showed that high Cav-1 expression was associated with shorter overall survival and disease free survival (P<0.001 for both). Multivariate analysis revealed that the Cav-1 expression was an independent prognostic factor for overall survival (P<0.014).

Conclusion

The expression of Cav-1 in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.

表1 Cav-1蛋白表达与患者临床病理的关系表
图1 Cav-1蛋白在结直肠癌组织中的表达
表2 单因素和多因素分析结直肠癌患者预后的因素表
图2 Kapian-meier方法分析患者的生存情况
图3 Western blot检测Cav-1在结直肠癌组织中的表达
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