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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (02): 161-165. doi: 10.3877/cma.j.issn.2095-3224.2025.02.008

• Reviews • Previous Articles     Next Articles

Research advances on the mechanism of slow transit constipation associated with intestinal microbiota

Yunkun Liu1,2,3,4, Caixiang Meng5, Le Wang1,2,3,4, Yue Xu1,2,3,4, Chen Ye1,2,3,4, Long Li1,2,3,4, Ning Li1,2,3,4, Qiyi Chen1,2,3,4,()   

  1. 1. Department of Functional Intestinal Diseases,General Surgery of Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200000,China
    2. Shanghai Gastrointestinal Microecology Research Center,Shanghai 200000,China
    3. Shanghai Institution of Gut Microbiota Research and Engineering Development,Shanghai 200000,China
    4. Clinical Research Center for Digestive Diseases,Tongji University School of Medicine,Shanghai 200000,China
    5. econd Department of General Surgery of First Hospital of Qinhuangdao,Qinhuangdao 066003,China
  • Received:2024-11-18 Online:2025-04-25 Published:2025-05-12
  • Contact: Qiyi Chen

Abstract:

Slow transit constipation (STC) is a complex chronic functional gastrointestinal disorder involving intestinal motility dysfunction,abnormal neural regulation,and dysbiosis of the gut microbiota.In recent years,the role of the gut microbiota in the pathogenesis of STC has gained increasing attention.Studies have shown that the composition of the gut microbiota,its metabolites,and its interactions with the host immune system play a crucial role in the development and progression of STC. This review summarizes the relationship between the gut microbiota and STC,exploring the mechanisms by which the microbiota regulates neural function,inflammatory responses,and intestinal motility. Additionally,the potential of microbiota-based interventions,such as probiotics and fecal microbiota transplantation,in the treatment of STC is discussed,providing new insights and references for future research and clinical applications.

Key words: Intestinal bacterial flora, Slowtransit constipation, Intestinal motility disorder, Fecal microbiota transplantation

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