Gut microbiota dysbiosis and functional intestinal disorders：from mechanistic insights to fecal microbiota transplantation therapy

doi:10.3877/cma.j.issn.2095-3224.2025.02.005

Abstract

Abstract:

Functional intestinal disorders（FIDs） are common chronic gastrointestinal diseases with complex mechanisms involving the gut-brain axis，immune system，and gut microbiota. Recent studies indicate that gut microbiota imbalance plays a crucial role in the onset and exacerbation of FIDs，especially in subtypes such as irritable bowel syndrome （IBS），functional diarrhea，and constipation. Fecal microbiota transplantation（FMT），as a method to modulate gut microbiota，has gained increasing attention and shown significant efficacy in some clinical trials. However，challenges remain in the application of FMT，particularly regarding efficacy sustainability，safety，and individual variability. Additionally，adjunctive treatments，such as probiotics and prebiotics，are also believed to have synergistic effects in symptom improvement. Future research will explore the potential for combined application of FMT with probiotics and optimize therapeutic strategies to achieve personalized and precise management of FIDs.

Key words: Functional intestinal disorders（FIDs）, Gut microbiota imbalance, Fecal microbiota transplantation（FMT）, Probiotics, Prebiotics

Wanyong Zhu, Le Wang, Yue Xu, Xinjun Wang, Chen Ye, Ning Li, Qiyi Chen, Long Li. Gut microbiota dysbiosis and functional intestinal disorders：from mechanistic insights to fecal microbiota transplantation therapy[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(02): 142-147.

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