Research progress on the mechanism of intestinal flora metabolites involved in the occurrence of chronic constipation

doi:10.3877/cma.j.issn.2095-3224.2023.06.010

Abstract

Abstract:

Chronic constipation is one of the most common functional gastrointestinal disorders in clinical practice. There are differences in the gut microbiota between constipated patients and the normal population, and their biodiversity is altered, suggesting that alterations in the microbiota may be related to the occurrence of constipation. Gut microbes and related metabolites can influence intestinal function and participate in the development of constipation by regulating intestine-related signaling pathways. In recent years, there is increasing evidence that the brain-gut-microbiota axis is closely related to the occurrence and development of constipation and has an important impact on the intestinal environment. Chronic constipation not only affects the physiological function of patients but also brings about different degrees of psychological disorders and reduces the quality of life of patients. Therefore, many scholars have devoted themselves to exploring the factors involved in the development of chronic constipation. However, the existing reports have not fully elucidated the regulatory mechanisms of gut microbes and host metabolism in the development of constipation, and many findings are divergent or even contradictory. In this paper, we will discuss the role of the brain-gut-microbe axis in chronic constipation from the perspective of gut microbes and gut metabolites, and further look into the potential therapeutic effects of probiotics and fecal bacteria transplantation on chronic constipation.

Key words: Constipation, Chronic constipation, Intestinal flora, Metabolites, Probiotics, Fecal microbial transplantation

Jixin He, Yanni Yang, Jiwei Wang, Jianguo Li, Ming Xie. Research progress on the mechanism of intestinal flora metabolites involved in the occurrence of chronic constipation[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(06): 495-499.

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