CACA guidelines for holistic integrative management of colon cancer （2024 Edition）has been updated with full reference to the latest research results at home and abroad，and the opinions of experts in related fields have been widely integrated. In the epidemiology section，the incidence and mortality rates of colorectal cancer have been updated according to the latest research data from the National Cancer Center. In the screening section，the starting age of screening for the general population has been changed to 45 years old. In the diagnosis section，peripheral blood MSI testing is included as one of the available options for patients with limited pathologic access. In the surgery section，it is recommended that experienced centers routinely perform CME procedures； additional clarification is provided on the safety of the procedure of taking specimens through the natural cavity. In the internal medicine section，evidence-based medical evidence for immunotherapy was added，recommending that immunotherapy be considered as a treatment option for patients with dMMR/MSI-H； the role of ctDNA in postoperative adjuvant therapy decision-making was described； immunotherapy was recommended as one of the therapeutic options for patients with liver metastases from MSI-H； and double-immunotherapy with nabulizumab in combination with ipilimumab was recommended as one of the available options for palliative care. In the section on traditional Chinese medicine，the “principle of evidence-based treatment” is adjusted to “principle of combining disease diagnosis and treatment with evidence-based treatment”，and the content of evidence-based treatment during the prevention and treatment of colon cancer is added，as well as the application of non-pharmacological therapies in traditional Chinese medicine.

The abscess above the levator ani muscle is a rare and difficult disease of Anorectal Department, which is acute and serious, the operation is an important treatment way, basically use incision to hang a line operation. Because this kind of abscess position is deep, lacunae big, through this surgical procedure still can injure perianal muscle of different degrees after the operation, destroy anus function and appearance, leave sequela. Professor Li Huashan creatively proposed the novel operation method of thread-drawing inside rectum based on his rich clinical experience of more than 30 years and the concept of minimally invasive surgery, which not only improved the radical treatment rate of this kind of abscess but also greatly protected the integrity of anal function and perianal morphology. This paper summarized clinical experience in the treatment of abscess above the levator ani muscle by rectum hanging in detail, and in order to promote this surgical method in clinical practice.

CACA guidelines for holistic integrative management of rectal cancer （2024 Edition）fully refers to the latest researches at home and abroad， integrates experts' opinions in relevant fields and forms an updated version.In the epidemiology section， according to the latest data of the National Cancer Center， the detailed data of incidence and mortality of colorectal cancer were updated.In the screening section， the beginning age for general population screening has changed to 45 years old.In the surgical section， novel evidences have been added to total mesocolectomy， natural orifice specimen extraction surgery， “robotic” surgery and transanal total mesorectal excision.In the internal medicine section， novel evidences have been added to immunotherapy， and it is recommended that patients with dMMR/MSI-H status can consider immunotherapy.Besides， based on the latest researches， the chemotherapy cycles for high-risk stage Ⅱ patients and low-risk stage Ⅲ patients have been updated.In the radiotherapy section， the principles of preoperative neoadjuvant chemoradio-therapy were refined and reset， and different plans were developed based on tumor staging， microsatellite status and anal preservation intention.The principles of combined chemoradiotherapy for rectal cancer and the opportunity of surgery after chemoradiotherapy were also updated.In the traditional Chinese medicine section， the principle of “treatment based on syndrome differentiation” has been changed to “the combination of treatment based on disease differentiation and treatment based on syndrome differentiation”.At last， the current edition have added “treatment based on syndrome differentiation during rectal cancer follow-up period” section and the application of nonpharmacological therapies in traditional Chinese medicine.

Colorectal cancer is one of the most common malignant digestive tumors, of which colectomy combined with regional lymphadenectomy is the standard treatment. However, the extent of lymphadenectomy has not reached a consensus. The concept of complete mesocolic excision (CME) with central vascular ligation (CVL) proposed by European surgeons has not made a clear definition about the margin of lymph node excision, while D3 lymphadenectomy proposed by Japanese guideline proved to have more perioperative risks, which seems some kind of over-treatment. In our country, right hemicolectomy standard has not been established, surgeons perform right colectomy following the CME strategy and lymphadenectomy following D2/D3 excision standard. So, we reviewed the characteristics of lymph node metastasis of right colon cancer, and the advantages and disadvantages of D2/D3 lymphadenectomy.

Colorectal cancer (CRC) is one of the most common gastrointestinal malignant tumors worldwide, and its incidence is increasing year by year. Studies have shown that tumor stroma plays an active role in the occurrence and development of tumors. Tumor stroma, through the interaction with tumor essence ingredient, it affects the progression of CRC and the ability of tumor metastasis it promotes the occurrence, development and metastasis of CRC. Therefore, it is very important to explore the specific role, molecular mechanism and mechanism of tumor stroma components in the progression of CRC clinical application is essential. This article reviews the current research progress of tumor stroma in CRC at home and abroad.

The patients with brain metastasis from colorectal cancer has a poor prognosis, and the current guidelines for the diagnosis and treatment of brain metastasis have not yet reached a unified consensus. Therefore, based on the guidelines for the diagnosis and treatment of metastatic colorectal cancer, the Chinese Colorectal Cancer Committee organized multi-disciplinary experts to integrate the relevant studies and combine with clinical practices, aiming at the issues and controversies about clinical characteristics, diagnosis and treatment, and follow-up of brain metastasis patients from colorectal cancer. After discussion and voting, Chinese experts consensus on multidisciplinary treatment of brain metastases from colorectal cancer (2020 version) was formed. This consensus could provide better guidance for clinicians and maximize the control of the patient's condition, improve the quality of life and prolong the survival time.

Small intestinal tumors，as a rare type of gastrointestinal tumor，have shown a continuous increase in incidence recent years. Due to the nonspecific clinical manifestations，it is easily confused with other gastrointestinal diseases，leading to difficulties in early detection and a high rate of delayed diagnosis. Moreover，the clinical diagnosis and treatment of small intestinal tumors are severely limited by the scarcity of available evidence. Therefore，the Colorectal Tumor Professional Committee of the Chinese Medical Doctor Association has organized multidisciplinary experts to compile the Chinese expert consensus on multidisciplinary comprehensive treatment of small intestinal tumors （2025 Edition）.This consensus integrates domestic and international research and clinical practice，focusing on the clinical characteristics，diagnostic criteria，treatment principles，and follow-up monitoring of small intestinal tumors.It aims to enhance the comprehensive diagnosis and treatment level of small intestinal tumors.

Colorectal cancer is the third most common cancer and the fourth leading cause of cancer-related deaths worldwide. Constitutive activation of Ras-Raf-Mek-Erk (MAPK) pathway plays an important role in the occurrence and development of CRC. V-raf murine sarcoma viral oncogene homolog (BRAF) is a kinase in the MAPK signaling pathway and plays an important role in the development of colorectal cancer. Clinical observations showed that BRAF V600E was found in approximately 8%~10% of CRC cases and was associated with significantly lower median overall survival. It has predictive value for the prognosis of colorectal cancer. A preliminary study on BRAF V600E mutation provides a new idea for molecular targeted therapy of colorectal cancer.

Colorectal cancer is one of the most common malignant tumors in China， ranking second in morbidity and fourth in mortality. Metastasis and recurrence are the leading causes of patient death， and the peritoneum is a frequent site of metastasis in colorectal cancer， second only to liver and lung metastases. However， the prognosis of peritoneal metastasis is much worse than hepatic and pulmonary metastasis. Colorectal cancer peritoneal metastasis is characterized by difficult early diagnosis， severe symptoms and poor prognosis. Its standardized diagnosis and treatment are crucial for improving the prognosis of patients and enhancing their quality of life. The Colorectal Cancer Professional Committee of the Chinese Medical Doctor Association organized authoritative experts in the field of colorectal cancer in China to compile the “Chinese Expert Consensus on the Diagnosis and Treatment of Colorectal Cancer Peritoneal Metastasis （2017 Edition）” as early as 2017， and revised it in 2022. In view of the research progress of colorectal cancer peritoneal metastasis， the Colorectal Cancer Professional Committee of the Chinese Medical Doctor Association organized domestic multidisciplinary experts to revise and update the “Chinese Expert Consensus on the Diagnosis and Treatment of Colorectal Cancer Peritoneal Metastasis （2017 Edition）” and the 2022 revision based on the latest research results and evidence-based medical evidence after repeated discussions. The “Expert Consensus on the Diagnosis and Treatment of Peritoneal Metastasis of Colorectal Cancer （2025 Edition）” was compiled， reaching a preliminary consensus on the definition， diagnosis，treatment and prevention of colorectal cancer peritoneal metastasis， with the aim of guiding and standardizing the diagnosis and treatment of colorectal cancer peritoneal metastasis， developing reasonable and effective comprehensive treatment plans， prolonging survival time and improving quality of life for colorectal cancer peritoneal metastasis patients， thereby raising the overall level of diagnosis and treatment for colorectal cancer in China.

Anorectal abscess is a common acute infectious disease in department of colorectal surgery. It is easy to spread to deep perianal spaces. Surgical incision and drainage are the main therapeutic principle. There are many surgical approaches and the classic approaches include external approach of external sphincter, intersphincteric approach and intrarectal approach. The irregular approach increases the formation of anal fistula or complex anal fistula and increases the risk of fecal incontinence. In this paper, the different operative approach of abscess is described, which can provide basis for standardized treatment, decrease the formation of anal fistula or complex anal fistula, reduce patients' complication, improve quality of life and save medical resources.