To investigate the short-term efficacy of robotic-assisted natural orifice specimen extraction surgery (NOSES) in patients with sigmoid colon cancer and rectal cancer.

A retrospective analysis of 31 patients with colorectal cancer who underwent robotic assistance in the Cancer Hospital of the Chinese Academy of Medical Sciences from July 2021 to October 2021, including 18 cases of rectal tumors and 13 cases of sigmoid colon tumors. All patients received the operation method according to the intraoperative conditions, observe the operation and postoperative recovery, postoperative pathological results, and understand the postoperative survival and tumor progression of the patients.

31 patients successfully were performed the operation, 17 patients underwent NOSES operation, and the remaining 14 patients underwent routine surgery for specimen collection. The patients in the NOSES group had a lower BMI [(22.59±2.70) cm vs. (25.48±2.34) cm, t=1.142, P=0.004]; a lower rate of lymph node metastasis in N stage (P=0.025); less intraoperative blood loss [(24.12±14.17) cm vs. (35.71±11.58) cm, t=0.896, P=0.020], and the first time to stand after surgery was earlier [(27.41±10.95) cm vs. (40.00±9.51) cm, t=1.227, P=0.002]. None of the 31 patients had surgery-related complications during the perioperative period. The postoperative follow-up time was 3~6 months, and no tumor recurrence, progression or death occurred in all patients.

Robot-assisted NOSES is safe and feasible in patients with sigmoid colon cancer and rectal cancer, and the short-term curative effect is satisfactory.