Analysis and prevention of postoperative anastomotic leakage in patients with colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2021.01.016

Abstract

Abstract:

Postoperative anastomotic leakage is one of the common postoperative complications of colorectal cancer. This paper summarizes and analyzes the risk factors related to anastomotic leakage after colorectal cancer surgery in recent years and analyzes and evaluates the various factors that lead to anastomotic leakage. In order to comprehensively analyze the risk factors of anastomotic leakage, and take effective preventive measures, to reduce the occurrence of anastomotic leakage is of great significance.

Key words: Colorectal neoplasms, Surgical operation, Anastomotic leakage, Prevention colostomy

Jiangpin Xu, Jun Ma, Hua Wang. Analysis and prevention of postoperative anastomotic leakage in patients with colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(01): 99-102.

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References 31

[1]	Paun BC, Cassie S, MacLean AR, et al. Postoperative complications following surgery for rectal cancer[J]. Ann Surg, 2010, 251(5): 807-818.
[2]	Frasson M, Flor-Lorente B, Rodríguez JL, et al. Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients [J]. Ann Surg, 2015, 262(2): 321-330.
[3]	蔡泽贤. 腹腔镜直肠癌前切除术后吻合口瘘的危险因素及预防 [J]. 中国现代普通外科进展, 2018, 21(2): 144-146.
[4]	Akiyoshi T, Ueno M, Fukunaga Y, et al. Effect of body mass index on short-term outcomes of patients undergoing laparoscopic resection for colorectal cancer: a single institution experience in Japan [J]. Surg Laparosc Endosc Percutan Tech, 2011, 21(6): 409-414.
[5]	夏孝垚，周凯. 结直肠术后吻合口瘘发生的危险因素Meta分析 [J]. 江苏医药, 2019, 45(11): 1162-1166.
[6]	曾庆智，黄启奎，邓杰建. 结直肠癌患者术后吻合口瘘发生的危险因素分析 [J]. 中国临床新医学, 2019, 12(11): 1236-1239.
[7]	Zaharie F, Mocan L, Tomuş C, et al. Risk factors for anastomotic leakage following colorectal resection for cancer [J]. Chirurgia(Bucur), 2012, 107(1): 27-32.
[8]	Penna M, Hompes R, Arnold S, et al. Incidence and risk factors for anastomotic failure in 1594 patients treated by transanal total mesorectal excision:results from the international TaTME registry [J]. Ann Surg, 2019, 269(4): 700-711.
[9]	Slieker JC, Komen N, Mannaerts GH, et al. Long-term and perioperative corticosteroids in anastomotic leakage: a prospective study of 259 left-sided colorectal anastomoses [J]. Arch Surg, 2012, 147(5): 447-452.
[10]	Modasi A, Pace D, Godwin M, et al. NSAID administration post colorectal surgery increases anastomotic leak rate: systematic review/meta-analysis [J]. Surg Endosc, 2019, 33(3): 879-885.
[11]	Rullier E, Laurent C, Garrelon JL, et al. Risk factors for anastomotic leakage after resection of rectal cancer [J]. Br J Surg, 1998, 85(3): 355-358.
[12]	李思源，赵鹏，李洪波, 等. 结直肠癌术后吻合口瘘的危险因素分析 [J].中国现代普通外科进展, 2015, 18(2): 163-164.
[13]	Kobayashi M, Mohri Y, Ohi M, et al. Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery [J]. Surg Today, 2014, 44(3): 487-493. URL
[14]	Katsuno H, Shiomi A, Ito M, et al. Comparison of symptomatic anastomotic leakage following laparoscopic and open low anterior resection for rectal cancer:a propensity score matching analysis of 1014 consecutive patients [J]. Surg Endosc, 2016, 30(7): 2848-2856.
[15]	张冬辉，何葵，庄哲宏, 等. 腹腔镜直肠癌前切除术学习曲线中并发吻合口瘘的原因 [J]. 中南大学学报（医学版）, 2017, 42(7): 814-819.
[16]	栾晓鹏，王金申，靖昌庆, 等. 腹腔镜结直肠手术学习曲线影响因素分析 [J]. 中国现代普通外科进展, 2015, 18(9): 677-680.
[17]	García-Granero E, Navarro F, Cerdán Santacruz C, et al. Individual surgeon is an independent risk factor for leak after double-stapled colorectal anastomosis: An institutional analysis of 800 patients [J]. Surgery, 2017, 162(5): 1006-1016.
[18]	Leenen JPL, Hentzen JEKR, Ockhuijsen HDL. Effectiveness of mechanical bowel preparation versus no preparation on anastomotic leakage in colorectal surgery: a systematic review and meta-analysis [J]. Updates Surg, 2019, 71(2): 227-236.
[19]	Garfinkle R, Abou-Khalil J, Morin N, et al. Is there a role for oral antibiotic preparation alone before colorectal surgery? ACS-NSQIP analysis by coarsened exact matching [J]. Dis Colon Rectum, 2017, 60(7): 729-737.
[20]	Parthasarathy M, Greensmith M, Bowers D. Risk factors for anastomotic leakage after colorectal resection: a retrospective analysis of 17518 patients [J]. Colorectal Dis, 2017, 19(3): 288-298.
[21]	潘博，周建平，董明. 直肠癌前切除术后吻合口漏危险因素分析 [J]. 中国实用外科杂志, 2018, 38(10): 1174-1176.
[22]	Lustosa SA, Matos D, Atallah AN, et al. Stapled versus handsewn methods for colorectal anastomosis surgery: a systematic review of randomized controlled trials [J]. Sao Paulo Med J, 2002, 120(5): 132-136.
[23]	Slesser AA, Pellino G, Shariq O, et al. Compression versus hand-sewn and stapled anastomosis in colorectal surgery: A systematic review and meta-analysis of randomized controlled trials [J]. Tech Coloproctol, 2016, 20(10): 667-676.
[24]	Vennix S, Abegg R, Bakker OJ, et al. Surgical re-interventions following colorectal surgery: open versus laparoscopic management of anastomotic leakage [J]. J Laparoendosc Adv Surg Tech A, 2013, 23(9): 739-744.
[25]	Allaix ME, Lena A, Degiuli M, et al. Intraoperative air leak test reduces the rate of postoperative anastomotic leak:Analysis of 777 laparoscopic left-sided colon resections [J]. Surg Endosc, 2019, 33(5): 1592-1599.
[26]	Wu Z, Van de Haar RC, Sparreboom CL, et al. Is the intraoperative air leak test effective in the prevention of colorectal anastomotic leakage? A systematic review and meta-analysis [J]. Int J Colorectal Dis, 2016, 31(8): 1409-1417.
[27]	Blanco-Colino R, Espin-Basany E. Intraoperative use of ICG fluorescence imaging to reduce the risk of anastomotic leakage in colorectal surgery: A systematic review and meta-analysis [J]. Tech Coloproctol, 2018, 22(1): 15-23.
[28]	Pisarska M, Gajewska N, Małczak P, et al. Defunctioning ileostomy reduces leakage rate in rectal cancer surgery-systematic review and meta-analysis [J]. Oncotarget, 2018, 9(29): 20816-20825.
[29]	Tan WS, Tang CL, Shi L, et al. Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer [J]. Br J Surg, 2009, 96(5): 462-472.
[30]	李薇，于威，刘铜军. 临时回肠造口在预防低位直肠癌术后吻合口瘘中的应用价值 [J]. 中华普通外科杂志, 2016, 31(1): 64-65.
[31]	Chen J, Zhang Y, Jiang C, et al. Temporary ileostomy versus colostomy for colorectal anastomosis: evidence from 12 studies [J]. Scand J Gastroenterol, 2013, 48(5): 556-562.

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