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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (06): 497-508. doi: 10.3877/cma.j.issn.2095-3224.2025.06.003

• Natural Orifice Specimen Extraction Surgery • Previous Articles    

Analysis of the current situation of over 120 000 natural orifice specimen extraction surgery (NOSES) clinical applications in China

Shaojun Yu1, Xu Guan2, Jianbao Zheng3, Guanyu Yu4, Hengchen Liu1, Guiyu Wang5, Wei Zhang4, Fanghai Han6, Danbo Wang7, Haitao Zhou2, Junhong Hu8, Jian Peng9, Hongliang Yao10, Qingsi He11, Yangchun Zheng12, Liang Kang13, Zhenning Wang14, Bo Jiang15, Zhiguo Xiong16, dan Ma17, Xuejun Sun3, Yunfeng Li18, Yongxiang Li19, ye Wei20, Zhijie Ding21, zhuqing Zhou22, Qingchao Tang5, Yaoping Li23, Fangqin Xue24, Ping Liu18, Dongning Liu25, China NOSES Alliance, NOSES Committee of China Anti⁃cancer Association, NOSES Study Group‌ of Colorectal Cancer Committee of the Chinese Medical Doctor Association, Taiyuan Li25, Kefeng Ding1, Xishan Wang2,()   

  1. 1Department of Colorectal Surgery and Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    2Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    3Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
    4Colorectal Surgery Department, Changhai Hospital, Naval Medical University. Shanghai, 200433 China
    5Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150006, China
    6Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University/‌Department of Gastrointestinal Surgery, Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510275, China
    7Department of Gynaecology, ‌Liaoning Provincial Cancer Hospital, Shenyang 110042, China
    8Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China
    9Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
    10Department of Gastrointestinal Surgery, Second Xiangya Hospital, Central South University, Changsha 410008, China
    11Department of Gastrointestinal Surgery, Qilu Hospital of Shandong University, Ji’nan 250012, China
    12Department of Gastrointestinal Surgery, Sichuan Cancer Hospital, Chengdu 610041, China
    13Department of Colorectal Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China
    14Department of Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110000, China
    15Department of Colorectal and Anal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, China
    16Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Wuhan 430079, China
    17Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    18Department of Colorectal Surgery, the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
    19Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
    20Department of General Surgery, Fudan University Huadong Hospital. Shanghai 200040, China
    21Department of Gastrointestinal Surgery, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, China
    22Department of Colorectal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China
    23Department of Colorectal Surgery, Shanxi Provincial People’s Hospital, Taiyuan 030001, China
    24Department of Gastrointestinal Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, China
    25Department of General Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, China
  • Received:2025-12-15 Online:2025-12-25 Published:2026-01-26
  • Contact: Xishan Wang

Abstract:

Objective

To analyze the current clinical application status of natural orifice specimen extraction surgery (NOSES) in China, providing important reference for its standardized and scientific promotion.

Methods

A WeChat-based questionnaire survey was conducted among physicians specializing in general surgery, oncological surgery, gynecology, and urology across China. The survey covered physician demographics, NOSES implementation status, challenges encountered, and the current state of NOSES technical training and research.

Results

The survey covered 31 provinces, autonomous regions, and municipalities in China, yielding 1 710 valid responses. Among respondents, 1 166 (68.2%) performed NOSES procedures, while 544 (31.8%) did not. A total of 854 hospitals performed NOSES procedures, conducting 120 835 cases. By specialty: colorectal tumors (86 430 cases, 71%); gastric tumors (11 574 cases, 10%); gynecological tumors (5 612 cases, 5%); other benign conditions (17 219 cases, 14%). By specimen retrieval route: 95 553 cases (79.1%) via the anus, 23 383 cases (19.4%) via the vagina, and 1 375 cases (1.1%) via anterior rectal wall incision. By proportion of NOSES procedures among similar surgeries, 478 hospitals performed NOSES procedures accounting for less than 10% of similar surgeries, 317 hospitals performed them between 10% and 20%, and 59 hospitals performed them at over 20%. The survey revealed that most physicians primarily encountered NOSES techniques through large academic conferences (53%). Training methods predominantly involved attending workshops (42%) and watching live surgical demonstrations by experts (38%). 88% of surgeons who have performed NOSES believed that their assistants should receive training in NOSES techniques at experienced centers, while 92% of those who have not performed NOSES agreed that they themselves need to undergo such training. 50.3% of surgeons who have performed NOSES held the view that their assistants can be authorized to independently perform the procedure after completing 10~20 cases of hands-on training, and 55.3% of those who have not performed NOSES believed that they can independently carry out the procedure after such training. 290 individuals conducted NOSES-related research projects, with 212 publishing Chinese papers and 125 publishing English papers. Database data uploads (67 individuals) increased by 42.86%, 26.19%, 50.60%, and 131.03% respectively compared to previous periods. 83.2% and 82.7% of hospitals support their institutions and physicians in performing NOSES procedures, with 99.5% of treated patients expressing high satisfaction with NOSES outcomes.

Conclusion

NOSES surgery has gained widespread attention and experienced rapid growth in China, with over 120 000 procedures performed across disciplines including colorectal, gastric, gynecological, hepatobiliary, and urological surgery. It has generated positive impacts at the hospital, physician, and patient levels. In recent years, young and middle-aged physicians have become the main force performing NOSES procedures; primary-care physicians outside tertiary hospitals have acquired the capability to routinely perform NOSES surgery; major academic conferences have increased awareness of NOSES procedures, with surgical demonstrations and training workshops driving its dissemination. Training at accredited centers remains the most efficient pathway for young physicians to master the technique. Currently, NOSES-related research articles and projects continue to increase, with clinical studies gradually emerging to provide higher-level evidence-based support for the technique.

Key words: Natural orifice specimen extraction surgery(NOSES), Minimal invasive surgery, Status analysis, Clinical application

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