The guideline for integrated diagnosis and treatment of cancer-NOSES technology (colorectal cancer section) was jointly developed by the NOSES Professional Committee and the Colorectal Cancer Professional Committee of the Chinese Anti-Cancer Association. It systematically elaborates on the nomenclature of NOSES procedures, indications and contraindications, aseptic and non-tumor surgical protocols, digestive tract reconstruction, and prevention and management of complications for natural orifice specimen extraction surgery (NOSES) in colorectal cancer. The guideline details 10 categories and 21 types of NOSES procedures, covering tumors in various segments of the colorectum, and clarifies the key technical points and applicable conditions for each procedure. The guideline emphasizes that surgical teams must possess extensive laparoscopic experience, strictly adhere to indications, and standardize aseptic and non-tumor techniques, including preoperative preparation, intraoperative skills, and postoperative management. Additionally, it summarizes strategies for preventing and managing major complications such as anastomotic leakage and intra-abdominal infections, providing critical references for the clinical application of NOSES in colorectal cancer.